Results 31 to 40 of about 80,661 (193)

Studies on Methylmalonyl-CoA Mutase from Propionibacterium shermanii [PDF]

European Journal of Biochemistry, 1974
1 Methylmalonyl-CoA mutase from Propionibacterium shermanii has been purified according to a modification of the method described by Wood et al. in 1964. 2 The final mutase preparation was homogeneous in the ultracentrifuge showing the following hydrodynamic properties: 8020,W= 7.25 S, D020,w= 5.71 F.
Boleslaw Zagalak, Janos Retey, Horst Sund   +2 more
openaire   +2 more sources

Overlooked components of lipid metabolism: Odd-chain polyunsaturated fatty acids in photosynthetic microorganisms. [PDF]

J Phycol
Abstract This mini‐review examines odd‐carbon polyunsaturated fatty acids (odd‐PUFAs), a rare but biologically significant group of fatty acids in photosynthetic microorganisms. Odd‐PUFAs are straight‐chain fatty acids containing an odd number of carbon atoms and two or more methylene‐interrupted double bonds. They typically account for less than 1% of
Nedbalová L, Vítová M, Řezanka T.
europepmc   +2 more sources

Review: State of the knowledge on the importance of folates and cobalamin for dairy cow metabolism

Animal, 2023
Synthesis of B vitamins by the rumen microbiota is usually sufficient to avoid the appearance of clinical deficiency symptoms in dairy cows under normal feeding conditions.
C.L. Girard, M. Duplessis
doaj   +1 more source

Gene Frequencies of Methylmalonic Acidemia Disease at the Global Level and Compiling the Pathogenic Mutations in the Iranian Population [PDF]

Research in Molecular Medicine, 2023
Background: Methylmalonic acidemia (MMA) is a rare autosomal recessive metabolic disorder resulting from a genetic defect in methylmalonyl-CoA mutase (MCM) or a defect in the biosynthesis of its cofactor, adenosyl-cobalamin (AdoCbl).
Ghazaleh Malekizadeh, Omid Jazayeri, Morteza Alijanpour, Majid Tafrihi   +3 more
doaj  

Systemic Messenger RNA Therapy as a Treatment for Methylmalonic Acidemia

Cell Reports, 2017
Summary: Isolated methylmalonic acidemia/aciduria (MMA) is a devastating metabolic disorder with poor outcomes despite current medical treatments. Like other mitochondrial enzymopathies, enzyme replacement therapy (ERT) is not available, and although ...
Ding An, Jessica L. Schneller, Andrea Frassetto, Shi Liang, Xuling Zhu, Ji-Sun Park, Matt Theisen, Sue-Jean Hong, Jenny Zhou, Raj Rajendran, Becca Levy, Rebecca Howell, Gilles Besin, Vladimir Presnyak, Staci Sabnis, Kerry E. Murphy-Benenato, E. Sathyajith Kumarasinghe, Timothy Salerno, Cosmin Mihai, Christine M. Lukacs, Randy J. Chandler, Lin T. Guey, Charles P. Venditti, Paolo G.V. Martini   +23 more
doaj   +1 more source

Relationships among nitrous oxide exposure, neurological injury and biomarkers. [PDF]

Br J Clin Pharmacol
Aims Recreational nitrous oxide (N2O) misuse is an increasing public health problem associated with functional cobalamin (B12) deficiency and severe neurological complications. Despite growing recognition of its harms, the dose–response relationship and clinical value of biomarkers remain unclear.
Bhujel L, Chiew AL, Jagarlamudi B, Chandru P, Gunja N, Briggs N, Chan BS.   +6 more
europepmc   +2 more sources

Long-term efficacy and safety of mRNA therapy in two murine models of methylmalonic acidemiaResearch in context

EBioMedicine, 2019
Background: Isolated methylmalonic acidemia/aciduria (MMA) is an ultra-rare, serious, inherited metabolic disorder with significant morbidity and mortality.
Ding An, Andrea Frassetto, Eric Jacquinet, Marianne Eybye, Joseph Milano, Christine DeAntonis, Vi Nguyen, Rodrigo Laureano, Jaclyn Milton, Staci Sabnis, Christine M. Lukacs, Lin T. Guey   +11 more
doaj   +1 more source

Primary structure and activity of mouse methylmalonyl-CoA mutase [PDF]

Biochemical Journal, 1990
Methylmalonyl-CoA mutase (MCM) is an adenosylcobalamin-dependent enzyme that catalyses isomerization between methylmalonyl-CoA and succinyl-CoA (3-carboxypropionyl-CoA). Genetic deficiency of this enzyme in man causes an often fatal disorder of organic acid metabolism termed mut methylmalonicacidaemia.
M F, Wilkemeyer, A M, Crane, F D, Ledley
openaire   +2 more sources

Construction of a novel anaerobic pathway in Escherichia coli for propionate production

BMC Biotechnology, 2017
Background Propionate is widely used as an important preservative and important chemical intermediate for synthesis of cellulose fibers, herbicides, perfumes and pharmaceuticals.
Jing Li, Xinna Zhu, Jing Chen, Dongdong Zhao, Xueli Zhang, Changhao Bi   +5 more
doaj   +1 more source

Clinical presentation, molecular analysis and follow-up of patients with mut methylmalonic acidemia in Shandong province, China

Pediatrics and Neonatology, 2020
Background: The mut methylmalonic acidemia (MMA) caused by the deficiency of methylmalonyl-CoA mutase (MCM) activity, which results from defects in the MUT gene.
Bingjuan Han, Wenying Nie, Meng Sun, Yingxia Liu, Zhiyang Cao   +4 more
doaj   +1 more source