Results 21 to 30 of about 76,676 (194)
Vitamin B12 - do we need it? [PDF]
Farmacja Polska, 2022 Vitamin B12 is a name for a number of chemicals based on the structure of Corrin's rings. Its main source in the diet are animal foods, in particular: meat, fish, dairy products and eggs. Plant products are usually low in cobalamin.
Krzysztof Mariusz Halczuk +1 more
doaj +1 more source
The NADPH oxidase NOX4 regulates redox and metabolic homeostasis preventing HCC progression
Hepatology, EarlyView., 2022 Loss of NOX4 in HCC tumor cells induces metabolic reprogramming in a Nrf2/MYC‐dependent manner to promote HCC progression. Abstract Background and Aims The NADPH oxidase NOX4 plays a tumor‐suppressor function in HCC. Silencing NOX4 confers higher proliferative and migratory capacity to HCC cells and increases their in vivo tumorigenic potential in ...
Irene Peñuelas‐Haro +14 more
wiley +1 more source
Versatile enzymology and heterogeneous phenotypes in cobalamin complementation type C disease
iScience, 2022 Summary: Nutritional deficiency and genetic errors that impair the transport, absorption, and utilization of vitamin B12 (B12) lead to hematological and neurological manifestations.
Anna J. Esser +6 more
doaj +1 more source
G3: Genes, Genomes, Genetics, 2023 The micronutrient vitamin B12 is an essential cofactor for two enzymes: methionine synthase, which plays a key role in the one-carbon cycle; and methylmalonyl-CoA mutase, an enzyme in a pathway that breaks down branched-chain amino acids and odd-chain ...
Grace Ying Shyen Goh +4 more
doaj +1 more source
Stem Cell Research, 2022 Methylmalonic acidemia(MMA) is an autosomal recessive hereditary disease caused by methylmalonyl-CoA mutase defect or its coenzyme cobalamin metabolism defect.
Jing Luan +6 more
doaj +1 more source
Nitric Oxide Inhibits Mammalian Methylmalonyl-CoA Mutase [PDF]
Journal of Biological Chemistry, 2005 Methylmalonyl-CoA mutase is a key enzyme in intermediary metabolism, and children deficient in enzyme activity have severe metabolic acidosis. We found that nitric oxide (NO) inhibits methylmalonyl-CoA mutase activity in rodent cell extracts. The inhibition of enzyme activity occurred within minutes and was not prevented by thiols, suggesting that ...
Amanpreet, Kambo +5 more
openaire +2 more sources
Animal Nutrition, 2022 Cattle can efficiently perform de novo generation of glucose through hepatic gluconeogenesis to meet post-weaning glucose demand. Substantial evidence points to cattle and non-ruminant animals being characterized by phylogenetic features in terms of ...
Guoyan Wang +8 more
doaj +1 more source
Review: State of the knowledge on the importance of folates and cobalamin for dairy cow metabolism
Animal, 2023 Synthesis of B vitamins by the rumen microbiota is usually sufficient to avoid the appearance of clinical deficiency symptoms in dairy cows under normal feeding conditions.
C.L. Girard, M. Duplessis
doaj +1 more source
Studies on Methylmalonyl-CoA Mutase from Propionibacterium shermanii [PDF]
European Journal of Biochemistry, 1974 1 Methylmalonyl-CoA mutase from Propionibacterium shermanii has been purified according to a modification of the method described by Wood et al. in 1964. 2 The final mutase preparation was homogeneous in the ultracentrifuge showing the following hydrodynamic properties: 8020,W= 7.25 S, D020,w= 5.71 F.
Boleslaw Zagalak +2 more
openaire +2 more sources
Gene Frequencies of Methylmalonic Acidemia Disease at the Global Level and Compiling the Pathogenic Mutations in the Iranian Population [PDF]
Research in Molecular Medicine, 2023 Background: Methylmalonic acidemia (MMA) is a rare autosomal recessive metabolic disorder resulting from a genetic defect in methylmalonyl-CoA mutase (MCM) or a defect in the biosynthesis of its cofactor, adenosyl-cobalamin (AdoCbl).
Ghazaleh Malekizadeh +3 more
doaj