Results 131 to 140 of about 12,925 (176)
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Mechanism of Methylmercury Cytotoxicity
CRC Critical Reviews in Toxicology, 1987Although a large number of epidemiological, clinical, and pathological studies on methylmercury intoxication have been published, these investigations have not been able to elucidate the detailed mechanisms by which the metal alkyl causes a wide variety of biological dysfunctions. Thus, the cultured cells which are free from the influence of whole body
Kyoko Miura +2 more
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Methylmercury Degradation by Trivalent Manganese
Environmental Science & Technology, 2023Methylmercury (MeHg) is a potent neurotoxin and has great adverse health impacts on humans. Organisms and sunlight-mediated demethylation are well-known detoxification pathways of MeHg, yet whether abiotic environmental components contribute to MeHg degradation remains poorly known.
Shuang Zhang +14 more
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Interactions of methylmercury with rat primary astrocyte cultures: methylmercury efflux
Brain Research, 1991Methylmercury (MeHg) efflux from rat astrocyte cultures was studied to complement our previous studies on uptake of MeHg in these cells. Exchange with extracellular MeHg was not obligatory for the efflux of [203Hg]MeHg into the extracellular media, because efflux occurred into MeHg-free extracellular media, but stimulation of [203Hg]MeHg net efflux was
M, Aschner, N B, Eberle, H K, Kimelberg
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Pharmacokinetics of methylmercury in sheep
Journal of Applied Toxicology, 1983AbstractA preliminary study of the pharmacokinetics of methylmercury was performed in sheep after a single intravenous dose of 203 Hg‐labeled methylmercury. Blood samples were taken periodically, and plasma and whole blood 203Hg were determined. Blood and plasma 203Hg concentrations exhibited a biphasic exponential decline.
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The uptake of methylmercury and methylmercury cysteine by the rainbow trout (Salmo gairdneri) kidney
General Pharmacology: The Vascular System, 1977Abstract 1. 1. In the rainbow trout ( Salmo gairdneri ), methylmercury (MeHg) cysteine (Cys) is preferentially taken-up by the kidney while unliganded MeHg is preferentially taken-up by the RBC. 2. 2. It appears that MeHg must be dissociated from Cys before it can cross the RBC membrane and that a portion of the total renal mercury uptake is ...
F J, Giblin, E J, Massaro
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Biliary transport of glutathione and methylmercury
American Journal of Physiology-Gastrointestinal and Liver Physiology, 1983The hepatobiliary transport of glutathione (GSH) and methylmercury (MM) was investigated in male and female rats anesthetized with pentobarbital sodium. When bile flow was altered with either sodium dehydrocholate (DHC), hypertonic sucrose infusion, or by hypothermia, the absolute rates of GSH and MM secretion into bile were not affected, resulting in
N, Ballatori, T W, Clarkson
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Neurophysiological evidence of methylmercury neurotoxicity
American Journal of Industrial Medicine, 2007AbstractBackgroundA variety of neurophysiological measures are useful in hospital settings for diagnostic and other clinical purposes. Previously, abnormal changes in various sensory evoked potentials (EPs), and heart rate variability (HRV) were observed in patients with acquired and fetal Minamata disease (MD; methylmercury poisoning). In recent years,
Murata, Katsuyuki +2 more
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Neurotoxicity and molecular effects of methylmercury
Brain Research Bulletin, 2001The neurotoxicity of high levels of methylmercury (MeHg) and the high susceptibility of the developing brain are well established both in humans and experimental animals. Prenatally poisoned children display a range of effects varying from severe cerebral palsy to subtle developmental delays.
CASTOLDI A. F. +3 more
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Toxicity of methylmercury in neonatal cats
Teratology, 1974AbstractKittens, 4–9 days old, from untreated mothers, received oral daily doses of 0.25–1 mg/kg Hg (as CH3HgCl) for various periods. Those given 0.25 and 0.37 mg/kg exhibited no clinical toxicity. At 0.5 mg/kg one of 3 kittens developed toxicity signs after 77 days of treatment whereas the others appeared healthy after 111 and 184 days of dosing ...
K S, Khera +4 more
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2014
Recently, twin sisters Jennie Gunhammar, a photographer, and, her sister, Jessie, a lecturer at the London School of Economics, both died within a year of each other of the autoimmune disease, systemic lupus erythematosus (SLE or lupus) aged just 35 (Jennie and Jessie pictured right). The story hit the UK headlines because Jennie’s long-term boyfriend,
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Recently, twin sisters Jennie Gunhammar, a photographer, and, her sister, Jessie, a lecturer at the London School of Economics, both died within a year of each other of the autoimmune disease, systemic lupus erythematosus (SLE or lupus) aged just 35 (Jennie and Jessie pictured right). The story hit the UK headlines because Jennie’s long-term boyfriend,
openaire +1 more source