Results 1 to 10 of about 132,460 (340)

Simultaneous analysis of dextran-methylprednisolone succinate, methylprednisolone succinate, and methylprednisolone by size-exclusion chromatography

Journal of Pharmaceutical and Biomedical Analysis, 1999
An analytical HPLC method is reported for simultaneous measurement of low (1.0-100 microg ml(-1)) concentrations of dextran-methylprednisolone succinate (DEX-MPS) and its degradation products methylprednisolone hemisuccinate (MPS) and methylprednisolone (MP).
openaire   +3 more sources

Pulse Methylprednisolone in SLE

Clinics in Rheumatic Diseases, 1982
Insufficient information is available about the effectiveness of high-dose intravenous corticosteroid treatment in non-renal SLE to determine whether it provides better management of the disease. Issues of steroid preparation, dose and frequency have not been addressed.
openaire   +3 more sources

Radioimmunoassay for methylprednisolone (medrol©)

Steroids, 1973
Abstract A precise, accurate, sensitive and specific double antibody radio-immunoassay for methylprednisolone (Medrol ® ) has been developed. The assay is capable of detecting femtogram (10 −9 μgrams) quantities of the drug in unextracted serum.
W.A. Colburn, R.H. Buller
openaire   +3 more sources

Methylprednisolone and Multiple Sclerosis

Archives of Neurology, 1988
The application of imaging methods in assessing disease activity in patients with multiple sclerosis (MS) is beginning to influence strategies for treatment. Meanwhile, most clinicians treat patients with severe disability symptomatically, reserving experimental therapies aimed at modifying the long-term course for those in whom disability is ...
openaire   +3 more sources

Analysis of cortisol, methylprednisolone, and methylprednisolone hemisuccinate

Journal of Chromatography B: Biomedical Sciences and Applications, 1984
A sensitive, selective, and reproducible high-performance liquid chromatographic assay for the simultaneous measurement of cortisol and methylprednisolone using dexamethasone as the internal standard is presented. Samples are extracted with methylene chloride, washed with sodium hydroxide and then water, and chromatographed on a microparticle silica ...
William F. Ebling, William J. Jusko, Stanley J. Szefler   +2 more
openaire   +3 more sources

Analysis of methylprednisolone, methylprednisone and corticosterone for assessment of methylprednisolone disposition in the rat

Journal of Chromatography B: Biomedical Sciences and Applications, 1988
A sensitive, specific and precise high-performance liquid chromatographic assay for the simultaneous determination of methylprednisolone, methylprednisone and corticosterone using betamethasone as the internal standard is reported. Rat serum (0.5 ml) is extracted with methylene chloride, washed with sodium hydroxide, then water and the extract is ...
William J. Jusko, David B. Haughey
openaire   +3 more sources

Methylprednisolone

Veterinary Record, 1984
P M, Taylor, J D, Littlewood
  +7 more sources

Methylprednisolone in Status Asthmaticus

Archives of Internal Medicine, 1984
To the Editor. —I would like to comment on the recent study by Haskell et al 1 in the JulyArchives. First, this article was welcomed, since there is a paucity of well-designed and executed studies using corticosteroids for treating status asthmaticus. Second, I would disagree slightly with the authors' interpretation of their data.
openaire   +3 more sources

Methylprednisolone Acetate In Vasectomy

JAMA: The Journal of the American Medical Association, 1972
To the Editor.— Those of your readers who perform vasectomies may be interested in the following observations. Over the past four months I have added methylprednisolone acetate (Depo-Medrol) to the 1% lidocaine hydrochloride (Xylocaine) solution which I routinely inject locally in vasectomies. The results have been quite striking and, in the interest
openaire   +3 more sources

Dextran-methylprednisolone succinate as a prodrug of methylprednisolone: dose-dependent pharmacokinetics in rats

International Journal of Pharmaceutics, 2001
The dose-dependency in the pharmacokinetics of a macromolecular prodrug of methylprednisolone (MP), dextran-methylprednisolone succinate (DMP), was investigated in rats. Single doses (MP equivalent) of 2.5, 5.0, 10, 20, and 30 mg/kg of DMP were administered intravenously to rats (n=5/group), and serial blood samples (0-96 h) and spleen and liver ...
Xiaoping Zhang, Reza Mehvar
openaire   +3 more sources