Results 11 to 20 of about 167,693 (338)

Methylprednisolone in Pediatric Cardiac Surgery: Is There Enough Evidence?

Frontiers in Cardiovascular Medicine, 2021
Corticosteroids have been used to decrease the inflammatory response to cardiac surgery and cardiopulmonary bypass in children for decades. Sparse information is present concerning the pharmacokinetics and pharmacodynamics of corticosteroids in the ...
Annewil van Saet, Gerdien A. Zeilmaker-Roest, Gerdien A. Zeilmaker-Roest, Robert J. Stolker, Ad J. J. C. Bogers, Dick Tibboel   +5 more
doaj   +1 more source

Dexamethasone vs methylprednisolone high dose for Covid-19 pneumonia

PLoS ONE, 2021
Background There is no effective therapy for the severe acute respiratory syndrome by coronavirus 2 (SARS-CoV2) responsible for the Coronavirus disease 2019 (Covid-19).
M. Pinzón, S. Ortiz, Héctor Holguín, J. Betancur, Doris Cardona Arango, Henry Laniado, Carolina Arias Arias, B. Muñoz, Julián Quiceno, Daniel Jaramillo, Zoraida Ramirez   +10 more
semanticscholar   +1 more source

Intravenous methylprednisolone pulses in hospitalised patients with severe COVID-19 pneumonia: a double-blind, randomised, placebo-controlled trial

European Respiratory Journal, 2022
Rationale Pulse glucocorticoid therapy is used in hyperinflammation related to coronavirus disease 2019 (COVID-19). We evaluated the efficacy and safety of pulse intravenous methylprednisolone in addition to standard treatment in COVID-19 pneumonia ...
C. Salvarani, M. Massari, M. Costantini, D. Merlo, Gabriella Lucia Mariani, Pierluigi Viale, S. Nava, G. Guaraldi, G. Dolci, L. Boni, L. Savoldi, P. Bruzzi, Caterina Turrà, M. Catanoso, A. Marata, Chiara Barbieri, Annamaria Valcavi, Francesca Franzoni, S. Cavuto, G. Mazzi, R. Corsini, F. Trapani, A. Bartoloni, E. Barisione, Chiara Barbieri, G. Burastero, A. Pan, W. Inojosa, R. Scala, C. Burattini, F. Luppi, M. Codeluppi, Kamal Eldin Tarek, G. Cenderello, M. Salio, G. Foti, R. Dongilli, G. Bajocchi, E. Negri, G. Ciusa, Giacomo Fornaro, I. Bassi, L. Zammarchi, T. Aloè, N. Facciolongo   +44 more
semanticscholar   +1 more source

Case report: Subacute combined degeneration of the spinal cord due to nitrous oxide abuse

Frontiers in Neurology, 2023
BackgroundNitrous oxide (N2O) is an increasingly popular recreational drug. N2O irreversibly disturbs the metabolism of vitamin B12, resulting in a functional deficiency.
Huijuan Wu, Huijuan Wu, Huiqing Huang, Liaoyang Xu, Niu Ji, Xinyu Zhou, Xinyu Zhou, Kang Xie   +7 more
doaj   +1 more source

Proptosis and Diplopia Response With Teprotumumab and Placebo vs the Recommended Treatment Regimen With Intravenous Methylprednisolone in Moderate to Severe Thyroid Eye Disease

JAMA ophthalmology, 2022
This meta-analysis conducts a matching-adjusted indirect comparison of teprotumumab vs intravenous methylprednisolone vs placebo in patients with moderate-to-severe thyroid eye disease.
Raymond S. Douglas, R. Dailey, P. Subramanian, Giuseppe Barbesino, Shoaib Ugradar, Ryan Batten, R. Qadeer, C. Cameron   +7 more
semanticscholar   +1 more source

Prolonged higher dose methylprednisolone versus conventional dexamethasone in COVID-19 pneumonia: a randomised controlled trial (MEDEAS)

European Respiratory Journal, 2022
Background Dysregulated systemic inflammation is the primary driver of mortality in severe coronavirus disease 2019 (COVID-19) pneumonia. Current guidelines favour a 7–10-day course of any glucocorticoid equivalent to dexamethasone 6 mg daily.
F. Salton, P. Confalonieri, S. Centanni, M. Mondoni, N. Petrosillo, P. Bonfanti, G. Lapadula, D. Lacedonia, A. Voza, N. Carpenè, M. Montico, Nicolò Reccardini, G. Meduri, B. Ruaro, M. Confalonieri, Gloria Maria Giulia Chiara Stefano Riccardo Alessia Giova Citton Lapadula Bozzi Tavano Pozzan Andrisano Jabe   +15 more
semanticscholar   +1 more source

Methylprednisolone for Heart Surgery in Infants - A Randomized, Controlled Trial.

New England Journal of Medicine, 2022
BACKGROUND Although perioperative prophylactic glucocorticoids have been used for decades, whether they improve outcomes in infants after heart surgery with cardiopulmonary bypass is unknown. METHODS We conducted a multicenter, prospective, randomized,
K. Hill, P. Kannankeril, J. Jacobs, H. Baldwin, M. Jacobs, Sean M. O'Brien, David P Bichel, E. Graham, Brian Blasiole, Ashraf Resheidat, Adil Husain, S. R. Kumar, J. Kirchner, D. Gallup, J. Turek, M. Bleiweis, B. Mettler, A. Benscoter, Eric L. Wald, T. Karamlou, Andrew H. Van Bergen, David Overman, P. Eghtesady, Ryan Butts, J. S. Kim, J. Scott, B. Anderson, Michael F Swartz, P. McConnell, D. Vener, Jennifer S. Li   +30 more
semanticscholar   +1 more source

Methylprednisolone in adults hospitalized with COVID-19 pneumonia

Wiener Klinische Wochenschrift, 2021
To determine whether a 6-day course of methylprednisolone (MP) improves outcome in patients with severe SARS-CoV‑2 (Corona Virus Disease 2019 [COVID-19]).
L. Corral-Gudino, A. Bahamonde, Francisco Arnaiz-Revillas, Julia Gómez-Barquero, Jésica Abadía-Otero, C. García-Ibarbia, V. Mora, Ana Cerezo-Hernández, J. Hernández, Graciela López-Muñíz, Fernando Hernández-Blanco, J. Cifrián, J. Olmos, Miguel F. Carrascosa, Luis Nieto, M. Fariñas, J. Riancho   +16 more
semanticscholar   +1 more source

Effects of Methylprednisolone on Myocardial Function and Microcirculation in Post-resuscitation: A Rat Model

Frontiers in Cardiovascular Medicine, 2022
BackgroundPrevious studies have demonstrated that inflammation and impaired microcirculation are key factors in post-resuscitation syndromes. Here, we investigated whether methylprednisolone (MP) could improve myocardial function and microcirculation by ...
Changsheng Wang, Changsheng Wang, Evelyne Bischof, Evelyne Bischof, Jing Xu, Qinyue Guo, Guanghui Zheng, Weiwei Ge, Juntao Hu, Elena Laura Georgescu Margarint, Jennifer L. Bradley, Mary Ann Peberdy, Mary Ann Peberdy, Joseph P. Ornato, Joseph P. Ornato, Changqing Zhu, Wanchun Tang, Wanchun Tang   +17 more
doaj   +1 more source

Effect of Vasopressin and Methylprednisolone vs Placebo on Return of Spontaneous Circulation in Patients With In-Hospital Cardiac Arrest: A Randomized Clinical Trial.

Journal of the American Medical Association (JAMA), 2021
Importance Previous trials have suggested that vasopressin and methylprednisolone administered during in-hospital cardiac arrest might improve outcomes.
L. Andersen, Dan Isbye, J. Kjærgaard, C. M. Kristensen, S. Darling, S. Zwisler, Stine Fisker, J. C. Schmidt, H. Kirkegaard, A. Grejs, Jørgen R G Rossau, J. Larsen, B. Rasmussen, S. Riddersholm, K. Iversen, M. Schultz, J. Nielsen, B. Løfgren, K. Lauridsen, Christoffer Sølling, Kim B. Pælestik, A. Kjærgaard, Dorte Due-Rasmussen, F. Folke, M. Charlot, Rikke Malene H G Jepsen, S. Wiberg, M. Donnino, T. Kurth, Maria Høybye, Birthe Sindberg, M. Holmberg, A. Granfeldt   +32 more
semanticscholar   +1 more source