Results 21 to 30 of about 81,349 (232)

Minocycline synergizes with corticosteroids in reducing colitis severity in mice via the modulation of pro-inflammatory molecules

Frontiers in Pharmacology, 2023
Background: A few studies have highlighted the anti-inflammatory properties of minocycline in reducing colitis severity in mice, but its molecular mechanism is not fully understood.
Maitham A. Khajah, Sanaa Hawai, Ahmad Barakat, Aisha Albaloushi, Maha Alkharji, Willias Masocha   +5 more
doaj   +1 more source

Methylprednisolone versus intravenous immune globulin as an initial therapy in adult primary immune thrombocytopenia [PDF]

The Korean Journal of Internal Medicine, 2019
Background/Aims Few studies have addressed whether there are differences in clinical efficacy between intravenous methylprednisolone (methyl-Pd) and intravenous immunoglobulin (IVIg) use.
Chul Hee Kim, Yoon Seok Choi, Ji Young Moon, Duck Yong Kim, So Yeon Lee, Hyo Jin Lee, Hwan Jung Yun, Samyong Kim, Deog Yeon Jo, Ik Chan Song   +9 more
doaj   +1 more source

Glucocorticoids Directly Affect Hyaluronan Production of Orbital Fibroblasts; A Potential Pleiotropic Effect in Graves’ Orbitopathy

Molecules, 2022
Orbital connective tissue expansion is a hallmark of Graves’ orbitopathy (GO). In moderate-to-severe active GO, glucocorticoids (GC) are the first line of treatment.
Erika Galgoczi, Monika Katko, Fruzsina Reka Papp, Robert Csiki, Sara Csiha, Annamaria Erdei, Miklos Bodor, Bernadett Ujhelyi, Zita Steiber, Ferenc Gyory, Endre V. Nagy   +10 more
doaj   +1 more source

Prolongation of Pregnancy in Patients with HELLP Syndrome Using Methylprednisolone: A Retrospective Multicentric Analysis

Life, 2023
Background: Immediate delivery is an established concept for preventing life-threatening complications in mothers with HELLP syndrome; however, it is associated with preterm births.
Anna Katharina Hosten, Jennifer Bonitz, Volker Thäle, Michael Tchirikov   +3 more
doaj   +1 more source

Evaluation of pulse therapy with intravenous methylprednisolone on leprosy neuritis in a Brazilian referral center

Frontiers in Tropical Diseases
BackgroundLeprosy neuritis (LN) is an immune hyperactivity majorly responsible for the deformities and sequelae present in leprosy disease. This observational study aimed to evaluate the use of intravenous methylprednisolone in refractory LN cases in a ...
Diogo Fernandes dos Santos, Diogo Fernandes dos Santos, Pedro Henrique Sirotheau Corrêa Alves, Fernanda de Oliveira Cirino, Leonardo Peixoto Garcia, João Paulo Moreira Fernandes, Douglas Eulálio Antunes, Isabela Maria Bernardes Goulart, Isabela Maria Bernardes Goulart   +8 more
doaj   +1 more source

Efficacy of Corticosteroid Therapy for HTLV-1-Associated Myelopathy: A Randomized Controlled Trial (HAMLET-P)

Viruses, 2022
Corticosteroids are most commonly used to treat HTLV-1-associated myelopathy (HAM); however, their clinical efficacy has not been tested in randomized clinical trials.
Junji Yamauchi, Kenichiro Tanabe, Tomoo Sato, Masanori Nakagawa, Eiji Matsuura, Yoshio Tsuboi, Keiko Tamaki, Hirokuni Sakima, Satoshi Ishihara, Yuki Ohta, Naoki Matsumoto, Kenichi Kono, Naoko Yagishita, Natsumi Araya, Katsunori Takahashi, Yasuo Kunitomo, Misako Nagasaka, Ariella Coler-Reilly, Yasuhiro Hasegawa, Abelardo Araujo, Steven Jacobson, Maria Fernanda Rios Grassi, Bernardo Galvão-Castro, Martin Bland, Graham P. Taylor, Fabiola Martin, Yoshihisa Yamano   +26 more
doaj   +1 more source

Acute Leukoencephalopathy with Diffusion Restriction in a Toddler

Current Medical Issues
We report a case of acute leukoencephalopathy with restricted diffusion (ALERD) in a 2½-year-old male who presented with fever, seizures, and altered sensorium.
Siva Vyasam, Jyothi Jayaram, Naga Anudeep Mylavarapu, Anuj Guleria, Siddharth Khanna, Renu Suthar, Suresh Kumar Angurana   +6 more
doaj   +1 more source

Adjunctive Therapeutic Plasma Exchange in Refractory Adult‐Onset Still's Disease Complicated by Secondary Macrophage Activation Syndrome: A Single‐Center Experience

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Adult‐onset Still's disease (AOSD) complicated by macrophage activation syndrome (MAS) carries substantial mortality. The role of therapeutic plasma exchange (TPE) remains uncertain. Methods We retrospectively analyzed patients with AOSD‐MAS treated with TPE at a single‐center.
Masataka Ueda, Tomohiro Saito, Masahide Mizobuchi, Tomoki Shimomura, Saki Kawamori, Mitsuru Kawanishi, Natsuko Hattori, Jo Sugiyama, Satoshi Tsubata, Hanami Horiguchi, Kazuki Abe, Nao Iida, Yuki Kajio, Nao Oguro, Ryo Yanai, Hirokazu Honda   +15 more
wiley   +1 more source

Methylprednisolone Decreases Mitochondria-Mediated Apoptosis and Autophagy Dysfunction in Hepatocytes of Experimental Autoimmune Hepatitis Model via the Akt/mTOR Signaling

Frontiers in Pharmacology, 2019
Autoimmune hepatitis (AIH) is characterized by massive immune cell-mediated hepatocyte destruction. Glucocorticoids, particularly methylprednisolone (MP), are the most effective treatment for AIH; however, the mechanism underlying the effects of ...
Xiaoli Fan, Ruoting Men, Haoran Wang, Mengyi Shen, Tingting Wang, Tinghong Ye, Xuefeng Luo, Li Yang   +7 more
doaj   +1 more source

Methylprednisolone in Pediatric Cardiac Surgery: Is There Enough Evidence?

Frontiers in Cardiovascular Medicine, 2021
Corticosteroids have been used to decrease the inflammatory response to cardiac surgery and cardiopulmonary bypass in children for decades. Sparse information is present concerning the pharmacokinetics and pharmacodynamics of corticosteroids in the ...
Annewil van Saet, Gerdien A. Zeilmaker-Roest, Gerdien A. Zeilmaker-Roest, Robert J. Stolker, Ad J. J. C. Bogers, Dick Tibboel   +5 more
doaj   +1 more source