Results 21 to 30 of about 167,693 (338)

Intravenous methylprednisolone pulse as a treatment for hospitalised severe COVID-19 patients: results from a randomised controlled clinical trial

European Respiratory Journal, 2020
Introduction There are no determined treatment agents for severe COVID-19. It is suggested that methylprednisolone, as an immunosuppressive treatment, can reduce the inflammation of the respiratory system in COVID-19 patients.
Maryam Edalatifard, M. Akhtari, M. Salehi, Z. Naderi, A. Jamshidi, S. Mostafaei, S. Najafizadeh, E. Farhadi, N. Jalili, M. Esfahani, B. Rahimi, Hossein Kazemzadeh, Maedeh Mahmoodi Aliabadi, T. Ghazanfari, M. Sattarian, Hourvash Ebrahimi Louyeh, S. Raeeskarami, Saeidreza Jamalimoghadamsiahkali, Nasim Khajavirad, M. Mahmoudi, A. Rostamian   +20 more
semanticscholar   +1 more source

Methylprednisolone improves the quality of liquid preserved boar spermatozoa in vitro and reduces polymorphonuclear neutrophil chemotaxis and phagocytosis

Frontiers in Veterinary Science, 2023
After artificial insemination, immune cells such as polymorphonuclear neutrophils will be recruited into the genital tract and induce endometrial inflammation, adversely affecting the spermatozoa.
Yanbing Li, Hechuan Wang, Shuo Wang, Qun Zhang, Han Zhang, Tianfeng Li, Qian Wang, Minghui Guo, Heze Feng, Yulun Song, Guosheng Wei, Jingchun Li   +11 more
doaj   +1 more source

Methylprednisolone as Adjunctive Therapy for Patients Hospitalized With COVID-19 (Metcovid): A Randomised, Double-Blind, Phase IIb, Placebo-Controlled Trial

Clinical Infectious Diseases, 2020
Background Steroid use for COVID-19 is based on the possible role of these drugs in mitigating the inflammatory response, mainly in the lungs, triggered by SARS-CoV-2.
Christiane Maria Prado Jerônimo, Maria Eduarda Leão de Farias, F. Val, V. Sampaio, M. Alexandre, G. Melo, I. Safe, M. Borba, Rebeca Linhares Abreu-Netto, Alex Bezerra da Silva Maciel, João Ricardo Silva Neto, Lucas Barbosa Oliveira, E. F. Figueiredo, Kelry Mazurega Oliveira Dinelly, Maria Gabriela Almeida Rodrigues, M. Brito, M. Mourão, Guilherme Augusto Pivoto João, L. Hajjar, Q. Bassat, G. Romero, F. Naveca, Heline Lira Vasconcelos, M. Tavares, J. Brito-Sousa, F. T. Costa, M. Nogueira, D. Baía-da-Silva, M. Xavier, W. Monteiro, M. Lacerda   +30 more
semanticscholar   +1 more source

A Comparison of Methylprednisolone and Dexamethasone in Intensive Care Patients With COVID-19

medRxiv, 2021
Objectives: This study retrospectively compares the effectiveness of methylprednisolone to dexamethasone in patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 or COVID-19) requiring intensive care.
J. Ko, Clay Wu, N. Mehta, Noah Wald-Dickler, Wei Yang, R. Qiao   +5 more
semanticscholar   +1 more source

Interstitial lung disease induced by apalutamide therapy for castration‐resistant prostate cancer: A report of a rare case

IJU Case Reports, 2022
Introduction Apalutamide is a new second‐generation anti‐androgen agent approved in 2019 for the treatment of metastatic, castration‐sensitive, and non‐metastatic, castration‐resistant prostate cancer.
Fumiaki Kirishima, Yoshinori Shigematsu, Kanao Kobayashi   +2 more
doaj   +1 more source

A case of ANA-negative systemic sclerosis treated with methylprednisolone [PDF]

JDVI (Journal of General Procedural Dermatology & Venereology Indonesia), 2019
Background: Systemic sclerosis is a multi-systemic disease characterized by excessive fibrosis, inflammation, and vasculopathy. Common clinical features include skin thickening, telangiectasias, salt and pepper skin, beak-shaped nose, and microstomy ...
Carminda P. Rogacion, Veronica S. Uy, Reynaldo L. Ugalde, Emmerson Gale S. Vista   +3 more
doaj   +1 more source

Beneficial effect of combinational methylprednisolone and remdesivir in hamster model of SARS-CoV-2 infection

Emerging Microbes and Infections, 2021
Effective treatments for coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are urgently needed.
Z. Ye, Shuofeng Yuan, J. Chan, A. J. Zhang, Ching-Yun Yu, C. Ong, Dong Yang, C. Chan, Kaiming Tang, Jianli Cao, V. Poon, C. Chan, Jian-Piao Cai, Hin Chu, K. Yuen, D. Jin   +15 more
semanticscholar   +1 more source

Methylprednisolone pulse therapy for critically ill patients with coronavirus disease 2019: A single‐center retrospective observational study

Acute Medicine & Surgery, 2022
Aim This study compared the clinical outcomes of critically ill patients with coronavirus disease (COVID‐19) pneumonia treated with high‐dose methylprednisolone and other steroids.
Hiromu Okano, Ryosuke Furuya, Shoko Niida, Sakura Minami, Hiroshi Horiuchi, Naoya Suzuki, Tsuyoshi Otsuka, Hiroshi Miyazaki   +7 more
doaj   +1 more source

Does methylprednisolone reduce the mortality risk in hospitalized COVID-19 patients? A meta-analysis of randomized control trials

Expert Review of Respiratory Medicine, 2021
Objectives: The question remained if mortality benefits with dexamethasone seen in patients with coronavirus disease 2019 (COVID-19) also extend to other systemic corticosteroids such as methylprednisolone.
S. Hasan, C. S. Kow, Z. Mustafa, H. Merchant   +3 more
semanticscholar   +1 more source

Effect of pulsed methylprednisolone on pain, in patients with HTLV-1-associated myelopathy [PDF]

, 2016
HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is an immune mediated myelopathy caused by the human T-lymphotropic virus type 1 (HTLV-1). The efficacy of treatments used for patients with HAM/TSP is uncertain.
Adonis, A, Buell, KG, Demontis, MA, Dhasmana, D, Haddow, J, Martin, F, Puri, A, Short, CL, Taylor, GP   +8 more
core   +1 more source