Results 61 to 70 of about 132,460 (340)

Engineering Topographical Cues to Enhance Neural Regeneration in Spinal Cord Injury: Overcoming Challenges and Advancing Therapies

Advanced Functional Materials, EarlyView.
Spinal cord injury (SCI) poses significant challenges for regeneration due to a series of secondary injury mechanisms. How to use biomaterial approach to target the failed regeneration after SCI remains a critical challenge. This review systematically evaluates current strategies to optimize biomaterial topographies for neurite outgrowth, axonal ...
Wei Xu, Fenghui Wang, Joshua Stein, Siqiao Wang, Pengfei Jiang, Letao Yang, Liming Cheng, Ki‐Bum Lee   +7 more
wiley   +1 more source

Possibilities of Inner Ear Barrier Models for Otologic Drug Development

Advanced Therapeutics, EarlyView.
This review examines innovative organ chip models that reconstruct critical inner ear barriers, addressing a fundamental challenge in otologic drug development: the limited understanding of pharmaceutical behavior across these complex barriers. By replicating these barriers, the advanced models offer promising alternatives to traditional testing ...
Yeji Ahn, Seonmin Choi, Minju Kim, Zachary Estlack, Daniel Brown, Jaehong Key, Young Joon Seo, Jungkyu Kim   +7 more
wiley   +1 more source

Personalized Medication for Chronic Diseases Using Multimodal Data‐Driven Chain‐of‐Decisions

Advanced Science, EarlyView.
A MDD‐CoD is proposed for personalized chronic disease medication. The framework simulates clinical chain‐of‐decisions through three linked deep learning tasks, validated on multi‐center datasets (3 hospitals, 4 diseases), demonstrating enhanced generalization and interpretability in cross‐disease applications.
Xiaoli Chu, Yiheng Ye, Siqiao Tang, Miaoru Han, Guowei Wang, Shuai Lin, Bingzhen Sun, Qingchun Huang, Yan Zhang, Xiaodong Chu, Kun Bao   +10 more
wiley   +1 more source

Glucocorticoids Directly Affect Hyaluronan Production of Orbital Fibroblasts; A Potential Pleiotropic Effect in Graves’ Orbitopathy

Molecules, 2022
Orbital connective tissue expansion is a hallmark of Graves’ orbitopathy (GO). In moderate-to-severe active GO, glucocorticoids (GC) are the first line of treatment.
Erika Galgoczi, Monika Katko, Fruzsina Reka Papp, Robert Csiki, Sara Csiha, Annamaria Erdei, Miklos Bodor, Bernadett Ujhelyi, Zita Steiber, Ferenc Gyory, Endre V. Nagy   +10 more
doaj   +1 more source

Retroperitoneal fibrosis: a case of a patient (63y/o) treated with low-dose methotrexate (MTX) and 6-methylprednisolone (6-MP) [PDF]

, 2018
Retroperitoneal fibrosis (RPF), is a rare fibroinflammatory disease. The pathogenesis of RPF is still unclear and numerous theories have been reported such as environmental factors, immunologic process, genetic component, local inflammation and advanced
A. Santoro, A. Sili Scavalli, N. Galea, R. Cirocchi, R. Poscia, ROSIELLO, FRANCESCO, V. Riccieri   +6 more
core  

Alemtuzumab induction and tacrolimus monotherapy in pancreas transplantation: One- and two-year outcomes [PDF]

, 2006
BACKGROUND. Alemtuzumab (Campath-1H) induction with tacrolimus monotherapy has been shown to provide effective immunosuppression for kidney, liver, lung, and small bowel transplantation.
Abu-Elmagd, Akhtar Khan, Amadeo Marcos, Amit Basu, Calne, Ciano, Deanna Blisard, Flechner, Gruessner, Hale, Henkie P. Tan, John J. Fung, Kaufmann, Kirk, Knechtle, Knechtle, Kusum Tom, Marcos, Marcos, McCurry, Ngoc L. Thai, Ron Shapiro, Shapiro, Shapiro, Starzl, Starzl, Starzl, Starzl, Stuart, Thai, Thomas E. Starzl, Tryphonopoulos, Tzakis, Watson   +33 more
core   +1 more source

Engineering Neutrophil Vesicles for Synergistic Protection against Ischemia/Reperfusion Injury after Lung Transplant

Advanced Science, EarlyView.
Engineered neutrophil‐derived vesicles (SOD2‐Fer‐1@CVs) co‐delivering antioxidant and ferroptosis‐inhibitory agents enable inflammation‐targeted, ROS‐responsive therapy for ischemia–reperfusion injury in lung transplantation. Synergizing with ex vivo lung perfusion, this strategy alleviates oxidative stress and inflammation, restores vascular integrity,
Hao‐Xiang Yuan, Yu‐Yun Ye, Pu Shen, Jie Zhang, Qian‐Fang Meng, Ying Chen, Xin Xu, Xuan‐Lin Zhang, Lang Rao, Zhi‐Jin Fan, Jian‐Xing He   +10 more
wiley   +1 more source

The Effects of Methylprednisolone and Hyaluronic Acid on the Endometrium in Experimentally Induced Asherman Syndrome Rat Models: A Prospective Laboratory Study

Medicina
Background and Objectives: The current study was designed as a prospective laboratory investigation to evaluate the histopathological effects and VEGF (vascular endothelial growth factor) expression in uterine tissue following treatment with a ...
Mehmet Genco, Merve Genco, Fisun Vural, Nermin Koç   +3 more
doaj   +1 more source

Iatrogenic meningitis

Arquivos de Neuro-Psiquiatria, 2013
Iatrogenic meningitis can be caused by a number of mechanisms. The recent case reports of fungal meningitis after application of epidural methylprednisolone caused warning in the medical community.
Eduardo Genaro Mutarelli, Tarso Adoni
doaj   +1 more source

Methylprednisolone Induces Neuro-Protective Effects via the Inhibition of A1 Astrocyte Activation in Traumatic Spinal Cord Injury Mouse Models

Frontiers in Neuroscience, 2021
Traumatic spinal cord injury (TSCI) leads to pathological changes such as inflammation, edema, and neuronal apoptosis. Methylprednisolone (MP) is a glucocorticoid that has a variety of beneficial effects, including decreasing inflammation and ischemic ...
Hong-jun Zou, Shi-Wu Guo, Lin Zhu, Xu Xu, Jin-bo Liu   +4 more
doaj   +1 more source