Results 81 to 90 of about 93,819 (293)

Methylprednisolone dosage effects on peripheral lymphocyte subpopulations and eicosanoid synthesis

, 1992
Methylprednisolone dosage effects on peripheral lymphocyte subpopulations and eicosanoid synthesis. Glucocorticoids have a major role in the treatment of glomerular diseases. Despite recent advances in understanding of their mechanism of action, very few
Rota, Stefano, Perna, Annalisa, Remuzzi, Giuseppe, Gaspari, Flavio, Garattini, Silvio, Benigni, Ariela, Daina, Erica, Noris, Marina, Rambaldi, Alessandro, Donadelli, Roberta   +9 more
core   +1 more source

“Membrane‐Guided” Repair Strategy: Precision Delivery of GGT1 Degrader for Targeted Repair and Regeneration of Spinal Cord Neurons

Advanced Science, EarlyView.
This study confirms that GGT1 is a key driver of neuronal ferroptosis following spinal cord injury. We developed NSCm@EA, a biomimetic delivery system coated with neural stem cell membranes, for precise delivery of enocyanin to injured neurons. By combining targeted delivery with ubiquitination degradation mechanisms, this system promotes MGRN1 ...
Tao Yang, Lei Ye, Peigen Xie, Tao Song, Jian Chen, Heng Zhao, Zhengshan Liu, Xi Chen, Jianing Ding, Xintian Ding, Ao Shao, Miaomiao Wu, Fengdong Zhao, Siyue Tao, Tao You   +14 more
wiley   +1 more source

Development of biodegradable methylprednisolone microparticles for treatment of articular pathology using a spray-drying technique

, 2013
Blanca Tobar-Grande,1 Ricardo Godoy,1 Paulina Bustos,2 Carlos von Plessing,1 Elias Fattal,3,4 Nicolas Tsapis,3,4 Claudia Olave,1 Carolina Gómez-Gaete11Departamento de Farmacia, Facultad de Farmacia, Universidad de Concepción, Concepci ...
Godoy R, Bustos P, von Plessing C, Olave C, Tobar-Grande B, Tsapis N, Gómez-Gaete C, Fattal E   +7 more
core  

Rethinking Perioperative Corticosteroids in Esophageal Cancer Surgery: Evidence From an Integrative Meta‐Analysis

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Background Esophagectomy remains a highly invasive procedure associated with substantial postoperative morbidity. Pulmonary complications, anastomotic leakage, and in‐hospital mortality are of particular concern. Perioperative corticosteroids are often administered to attenuate excessive inflammatory responses; however, the clinical impact in ...
Tomohiko Yasuda, Akihisa Matsuda, Nobutoshi Hagiwara, Yoshiharu Nakamura, Hiroshi Yoshida   +4 more
wiley   +1 more source

Thermodynamic properties of methylprednisolone aceponate

, 2020
© 2016 Elsevier LtdIn the present work, temperature dependence of heat capacity of methylprednisolone aceponate has been measured for the first time over the range from 7 K to 346 K by precision adiabatic vacuum calorimetry.
Shipilova A., Verevkin S., Samosudova Y., Smirnova N., Markin A., Knyazev A., Stepanova O., Emel'yanenko V., Gusarova E., Knyazeva S.   +9 more
core  

Immunoadsorption versus double-dose methylprednisolone in refractory multiple sclerosis relapses

, 2023
Objective: Intravenous methylprednisolone is the standard treatment for a multiple sclerosis relapse; however, this fails to improve symptoms in up to one quarter of patients.
Steffen, F. (Falk), Rolfes, L. (Leoni), Gross, C.C. (Catharina), Klotz, L. (Luisa), Wirth, T. (Timo), Pfeuffer, S. (Steffen), Pawlitzki, M. (Marc), Schulte-Mecklenbeck, A. (Andreas), Ruck, T. (Tobias), Meuth, S. (Sven), Bittner, S. (Stefan), Wiendl, H. (Heinz), Brand, M. (Marcus)   +12 more
core   +1 more source

Atypical Clinical Course of Griscelli Syndrome Type 2 With Primarily Neurologic Presentation and Adult‐Onset in a 46‐Year‐Old Male

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Griscelli Syndrome Type 2 (GS2) is a rare autosomal recessive disorder caused by pathogenic mutations in the RAB27A gene. Typically, it is characterized by cutaneous hypopigmentation, immunodeficiency, with or without neurological abnormalities secondary to hemophagocytic lymphohistiocytosis (HLH). Without treatment, GS2 often results in fatal
Dzhoy Papingi, Michael Kutsche, Helena Lichtenfeld, Fanny Kortüm, Angela Abicht, Laura Herrmann, Theresia Herget   +6 more
wiley   +1 more source

Efficacy of methylprednisolone versus other pharmacologic interventions for the treatment of central post-stroke pain: a retrospective analysis

, 2013
Anthony J Pellicane, Scott R Millis Department of Physical Medicine and Rehabilitation, Wayne State University School of Medicine, Rehabilitation Institute of Michigan in the Detroit Medical Center, Detroit, MI, USA Purpose: To determine if an oral ...
Millis SR, Pellicane AJ
core  

Comprehensive thermodynamic study of methylprednisolone [PDF]

, 2017
© 2016 Elsevier LtdIn the present work the temperature dependence of heat capacity for methylprednisolone has been measured for the first time over the temperature range from 6 to 350 K using by precision adiabatic vacuum calorimetry.
Shipilova A., Zaitsau D., Verevkin S., Smirnova N., Markin A., Knyazev A., Stepanova O., Emel'yanenko V., Gusarova E., Knyazeva S.   +9 more
core  

Porcine kidney xenotransplantation: From primate models to clinical reality

Animal Models and Experimental Medicine, EarlyView.
In the face of a critical shortage of human donor kidneys for end‐stage renal disease patients, porcine kidney xenotransplantation has emerged as a viable solution. This field has navigated major hurdles, including immune rejection, physiological incompatibilities, potential biomechanical differences and the risk of cross‐species infection. To overcome
Zihang Guo, Ling Zhang, Shoulong Deng, Chuan Qin   +3 more
wiley   +1 more source