Results 71 to 80 of about 112,591 (320)

Effects of Methylprednisolone on Myocardial Function and Microcirculation in Post-resuscitation: A Rat Model

Frontiers in Cardiovascular Medicine, 2022
BackgroundPrevious studies have demonstrated that inflammation and impaired microcirculation are key factors in post-resuscitation syndromes. Here, we investigated whether methylprednisolone (MP) could improve myocardial function and microcirculation by ...
Changsheng Wang, Changsheng Wang, Evelyne Bischof, Evelyne Bischof, Jing Xu, Qinyue Guo, Guanghui Zheng, Weiwei Ge, Juntao Hu, Elena Laura Georgescu Margarint, Jennifer L. Bradley, Mary Ann Peberdy, Mary Ann Peberdy, Joseph P. Ornato, Joseph P. Ornato, Changqing Zhu, Wanchun Tang, Wanchun Tang   +17 more
doaj   +1 more source

Association of Elevated Platelets and C‐Reactive Protein With Severe Disease and Poor Survival in Systemic Sclerosis

Arthritis Care &Research, EarlyView.
Objective Elevated C‐reactive protein (CRP) levels in systemic sclerosis (SSc) have been linked with severe disease and worse survival, but the role of platelet levels remains unclear. This study examined whether elevated platelet levels, CRP levels, or both are associated with disease severity, progression, and survival in SSc.
Brian S. Lee, Shufeng Li, Srijana Davuluri, Jennifer Lee, Lorinda Chung   +4 more
wiley   +1 more source

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

Atrial Fibrillation Induced by Oral Methylprednisolone

, 2002
Objective To report a case of atrial fibrillation (AF) due to oral methylprednisolone. Case Summary A 45-year-old white man with chronic intermittent paroxysmal supraventricular tachycardia (PSVT) reacted to oral methylprednisolone by developing a PSVT ...
Moshe Kerstein, Samuel Juni
core   +1 more source

Role of intravascular methylprednisolone in surgical impaction: An original research [PDF]

, 2022
Introduction: Mandibular impacted third molar surgical extraction may cause pain, trismus and swelling. Hence in this study we aim to evaluate the effect of methylprednisolone injection into the muscles on pain edema and trismus post third molar ...
Sharma, A. (Akshat), Kanakareddi, Bhagyashree, Pendyala, S. K. (Siva), Lalitha, P. L. (Pulavarthi), Srivastava, Amartya Prakash, Lalitha, Pulavarthi L., Kanakareddi, B. (Bhagyashree), Pendyala, Siva Kumar, Sharma, Akshat, Gangadharappa, P. (Praveen), Gangadharappa, Praveen, Srivastava, A. P. (Amartya)   +11 more
core   +1 more source

Ionizable Lipid‐Dependent Optimization of Steroid Lipid Nanoparticles With Tunable Immunomodulatory Properties

Advanced Materials, EarlyView.
A novel engineering strategy that establishes material design principles for incorporating anti‐inflammatory steroids into lipid nanoparticles to reduce LNP‐induced inflammation while retaining mRNA delivery. Results are validated in vitro and in three animal models of inflammation and autoimmunity in vivo.
Ajay S. Thatte, Benjamin E. Nachod, Julia Baena, Jenna Muscat‐Rivera, Lesley Chaboub, Hannah C. Safford, Hannah C. Geisler, Hannah M. Yamagata, Melgious J. Y. Ang, Michael Kegel, Alexandre Poirier, Elaine R. Tong, Zhe Zhong, Qiangqiang Shi, Jinjin Wang, Elisa Battistini, Ye Zeng, Alex G. Hamilton, Kelsey L. Swingle, Drew Weissman, Jilian R. Melamed, Michael J. Mitchell   +21 more
wiley   +1 more source

Single-cell RNA sequencing uncovers molecular mechanisms of intravenous immunoglobulin plus methylprednisolone in Kawasaki disease: attenuated monocyte-driven inflammation and improved NK cell cytotoxicity

Frontiers in Immunology
IntroductionIntravenous immunoglobulin (IVIG) plus methylprednisolone as initial intensive therapy or additional therapy in Kawasaki disease (KD) has been used in clinical practice.
Minna Yang, Yeshi Chen, Chenhui Feng, Mingming Zhang, Hongmao Wang, Yang Zheng, Xiaohui Li, Xiaohui Li, Xiaohui Li   +8 more
doaj   +1 more source

Judicious use of low-dosage corticosteroids for non-severe COVID-19: A case report

Open Medicine, 2021
Inflammation-mediated lung injury in severe cases of infection with SARS-CoV-2, the aetiological agent of Coronavirus disease 2019 (COVID-19), can lead to respiratory failure and death, and therapies that block or ameliorate lung injury-associated ...
Zhang Jian, Tian Zigang, Feng Lina, Yang Zhongming, Zou Bo, Li Kun, Zhang Yingliang, Wang Yaguo, Fleming Joy, Cui Wenyu   +9 more
doaj   +1 more source

Upadacitinib Restrains the Pathogenic Fitness of CD4+ T Cells and Aberrant B Cell Programming in Optic Neuritis

Advanced Science, EarlyView.
Single‐cell profiling and functional perturbation reveal coordinated JAK1‐pSTAT3 downstream programs in optic neuritis, including MCL1‐dependent fitness of pathogenic CD4+ Tem cells and glycolysis‐linked, cholesterol‐sensitive B‐cell responses associated with RORA. Upadacitinib disrupts this reciprocal T‐B‐cell circuit and alleviates neuroinflammation,
Gengchen Jiang, Qi Jiang, Lian Han, Yue Peng, Xingyu Liu, Tong Yang, Hao Huang, Jiaying Liu, Yuan Gao, Hui Yang, Wenjun Zou, Zhaohuai Li, Wenru Su   +12 more
wiley   +1 more source

Severe ADEM‐Like Neuroinflammatory Disease and Cerebrovascular Fragility With Recurrent Pseudoaneurysms and Moyamoya in a Familial Germline CBL Mutation: Expanding the Clinical Phenotype

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Heterozygous germline variants in CBL disrupt its function as a negative regulator of the Ras/MAPK pathway, classically predisposing to Juvenile myelomonocytic leukemia (JMML) and moyamoya. We describe two affected siblings carrying a paternally inherited CBL variant (c.1210 T> C, p.
Michal Bar‐Hakim, Anat Abramovich, Sara Via‐Dorembus, Gali Heimer, Bruria Ben‐Zeev, Etai Adam, Assaf A. Barg, Jonathan Roth, Basheer Sheick‐Yousif, Rony Beeri Berkowiz, Michal Feldon, Haim Bassan, Moran Hausman‐Kedem   +12 more
wiley   +1 more source