Results 71 to 80 of about 135,317 (323)

Neuroprotection and Axonal Regeneration via ECM‐Mimetic Nanofibers Incorporating Metal–Phenolic Network Nanoparticles Toward Spinal Cord Injury Repair

Advanced Science, EarlyView.
Metal–phenolic network (MPN) nanoparticles with neuroprotective functions are integrated into decellularized extracellular matrix (dECM) to obtain biomimetic composite fibrous scaffold MPN@dECM NFs by electrospinning, which protects spared neurons from secondary degeneration by suppressing excitotoxicity and inflammation, and promotes directional ...
Shu Chen, Bixue Wang, Qiya Zhang, Changsheng Liu, Xi Chen   +4 more
wiley   +1 more source

Effects of glucocorticoid immunosuppression on serum cystatin C levels [PDF]

Journal of Medical Biochemistry, 2009
The aim of the present study is to describe the influence of glucocorticoid immunosuppression on serum cystatin C concentration in renal transplant patients.
Gruev Todor, Chakalarovski Koco, Stojceva-Taneva Olivera, Grueva Ani, Trenceva Katerina   +4 more
doaj  

Repurposing of Chemokine Antagonists for Combined Phase‐Resolved Spinal Cord Injury Treatment

Advanced Science, EarlyView.
Spinal cord injury (SCI) in mammals is accompanied by a massive cytokine storm in cerebrospinal fluid, mainly driven by CXCL1, IL‐6, and CCL2‐5. Sub‐acute phase is mostly associated with IL‐2, IL‐7, CCL22, and CX3CL1, whereas TNFα and IL17α permanently persists in CNS even weeks following SCI.
Alexey A. Belogurov Jr., Georgii B. Telegin, Aleksandr S. Chernov, Anna A. Kudriaeva, Alexey N. Minakov, Maksim V. Rodionov, Vitaly A. Kazakov, Viktor A. Palikov, Yuri M. Poluektov, Rustam H. Ziganshin, Daria A. Orlova, Alena S. Evpak, Daniil A. Barsuk, Fedor A. Mesheryakov, Aldo Spallone, Dmitry S. Asyutin, Igor N. Pronin, Nikolay A. Konovalov, Dmitri Yu Usachev, Alexander G. Gabibov, Alexander N. Konovalov   +20 more
wiley   +1 more source

Induced liver injury after high-dose methylprednisolone in a patient with multiple sclerosis [PDF]

, 2015
A 33-year-old woman with multiple sclerosis, medicated with high doses of methylprednisolone, cyclophosphamide and glatiramer acetate, was referred to our department due to acute liver injury.
Cipriano, MA, Lopes, S, Oliveira, AT, Sofia, C   +3 more
core   +1 more source

Clinical–Radiological Spectrum of Cerebral Amyloid Angiopathy‐Related Inflammation

Annals of Neurology, EarlyView.
Objective To identify clinical and radiological features of cerebral amyloid angiopathy‐related inflammation (CAA‐ri), and compare these features with those of sporadic CAA, to improve the understanding, diagnosis, and clinical care of CAA‐ri. Methods We retrospectively reviewed routine clinical data from 37 patients with CAA‐ri and 158 patients with ...
Larysa Panteleienko, Gargi Banerjee, Dermot Mallon, Kitti Thiankhaw, Rupert Oliver, Victoria Harvey, Gareth Ambler, Michael Zandi, Hans Rolf Jäger, David J. Werring   +9 more
wiley   +1 more source

Single-cell RNA sequencing uncovers molecular mechanisms of intravenous immunoglobulin plus methylprednisolone in Kawasaki disease: attenuated monocyte-driven inflammation and improved NK cell cytotoxicity

Frontiers in Immunology
IntroductionIntravenous immunoglobulin (IVIG) plus methylprednisolone as initial intensive therapy or additional therapy in Kawasaki disease (KD) has been used in clinical practice.
Minna Yang, Yeshi Chen, Chenhui Feng, Mingming Zhang, Hongmao Wang, Yang Zheng, Xiaohui Li, Xiaohui Li, Xiaohui Li   +8 more
doaj   +1 more source

Use of Corticosteroids in Coronavirus Disease 2019 Pneumonia: A Systematic Review of the Literature

Frontiers in Medicine, 2020
The aim was to investigate the effectiveness of glucocorticoid therapy in patients with COVID-19. A systematic search of the literature across nine databases was conducted from inception until 15th March 2020, following the PRISMA guidelines.
Nicola Veronese, Jacopo Demurtas, Jacopo Demurtas, Lin Yang, Lin Yang, Roberto Tonelli, Roberto Tonelli, Mario Barbagallo, Pierluigi Lopalco, Erik Lagolio, Stefano Celotto, Damiano Pizzol, Liye Zou, Mark A. Tully, Petre Cristian Ilie, Mike Trott, Guillermo F. López-Sánchez, Lee Smith   +17 more
doaj   +1 more source

Impact of Interleukin‐1 Blockade on the Development of Macrophage Activation Syndrome in Still Disease: Incidence and Diagnostic Validity of the EULAR/ACR/PRINTO 2016 MAS Classification Criteria

Arthritis &Rheumatology, EarlyView.
Objective To evaluate the applicability of the 2016 European Alliance of Associations for Rheumatology (EULAR)/American College of Rheumatology (ACR)/Paediatric Rheumatology International Trials Organisation (PRINTO) macrophage activation syndrome (MAS) classification criteria in patients with Still disease and systemic juvenile idiopathic arthritis ...
Remco G. A. Erkens, Greta Rogani, Laura Huber, Anouk Verwoerd, Dieneke Schonenberg‐Meinema, J. Merlijn van den Berg, Wineke Armbrust, G. Elizabeth Legger, Sylvia Kamphuis, Ellen J. H. Schatorjé, Esther P. A. H. Hoppenreijs, Joost F. Swart, Marc H. A. Jansen, Jorg van Loosdregt, Sebastiaan J. Vastert   +14 more
wiley   +1 more source

The Application of Methylprednisolone Nanoscale Zirconium-Porphyrin Metal-Organic Framework (MPS-NPMOF) in the Treatment of Photoreceptor Degeneration

International Journal of Nanomedicine, 2019
Yajie Wang,1,2,* Wei Liu,3,4,* Bo Yuan,1,2 Xuebo Yin,3 Yiming Li,1 Zongjin Li,1 Jianlin Cui,1 Xiaoyong Yuan,2 Yuhao Li1,5 1Tianjin Key Laboratory of Tumor Microenvironment and Neurovascular Regulation, Nankai University School of Medicine, Tianjin 300071,
Wang Y, Liu W, Yuan B, Yin X, Li Y, Li Z, Cui J, Yuan X, Li Y   +8 more
doaj  

Efficacy and safety of low dose oral prednisolone as compared to pulse intravenous methylprednisolone in managing moderate severe Graves′ orbitopathy: A randomized controlled trial

Indian Journal of Endocrinology and Metabolism, 2015
Background: High dose oral prednisolone (100 mg/day) in Graves′ orbitopathy (GO) is limited by lesser response, and greater side-effects compared to intravenous (iv) methylprednisolone. Low dose oral prednisolone has not been evaluated in GO.
Ajitesh Roy, Deep Dutta, Sujoy Ghosh, Pradip Mukhopadhyay, Satinath Mukhopadhyay, Subhankar Chowdhury   +5 more
doaj   +1 more source