Results 81 to 90 of about 371 (109)
International Journal of Pharmaceutics, 2013 Trans-scleral iontophoresis, i.e. the application of small electric current to enhance drug transport across sclera is an option for non-invasive delivery of corticosteroids to the posterior segment of the eye. In this paper, in vitro trans-scleral iontophoresis of methylprednisolone hemisuccinate was investigated using concentrated drug solutions and ...
Daniela Martini +2 more
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Journal of Chromatography A, 1979 Abstract A reversed-phase high-performance liquid chromatographic (HPLC) procedure for the determination of hydrocortisone hemisuccinate and methylprednisolone hemisuccinate and their corresponding free steroids in experimental, lyophilized products of the hemiesters is described. The method is suitable as a stability-indicating assay.
D J Hoffman
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Microporous and Mesoporous Materials, 2017 Mesoporous SBA-15 silica materials functionalized with several organic moieties, that include different polarities and hydrophobicities, were investigated as matrices for controlled drug delivery. The functionalities were incorporated into SBA-15 using two methods: direct synthesis or co-condensation route and post-synthesis grafting ...
Josefa Ortiz-Bustos +2 more
exaly +4 more sources
Biomedical Applications, 2000 A size exclusion chromatographic method is presented for the measurement of the concentrations of a macromolecular prodrug of methylprednisolone (MP), dextran-methylprednisolone succinate (DEX-MPS), in rat plasma. After precipitation of the plasma (100 microl) proteins with perchloric acid, the samples are injected into a size exclusion column with a ...
Reza Mehvar
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Urticaria to methylprednisolone sodium hemisuccinate
Allergy: European Journal of Allergy and Clinical Immunology, 2001 P A Galindo, F Feo
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Biomedical Applications, 1979 A high-performance liquid chromatographic method is described for the simultaneous determination of methylprednisolone (MP) and methylprednisolone hemisuccinate (MPHS), or hydrocortisone (HC) and hydrocortisone hemisuccinate (HCHS) in human serum. Reversed-phase liquid chromatography was performed on a microparticulate C18 column (Spherisorb, 5 micron)
Marilyn Dix Smith
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Biomedical Applications, 1985 A rapid method for the measurement of methylprednisolone and its 21-hemisuccinate ester in plasma and urine following high dose pulse therapy is described. The drugs were extracted using Extrelut columns, eluted with ethyl acetate which was evaporated to dryness and the residue was reconstituted in chromatographic mobile phase.
Graham J. Lawson
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Pharmacological Research Communications, 1980
Summary Enzymatic hydrolysis of methylprednisolone hemisuccinate with a non-specific carboxylesterase from hog liver was examined. The carboxyl-exterase was found to be useful in hydrolyzing methylprednisolone hemisuccinate to methylprednisolone.
T, Oshima, E, Nakajima, K, Hattori
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Summary Enzymatic hydrolysis of methylprednisolone hemisuccinate with a non-specific carboxylesterase from hog liver was examined. The carboxyl-exterase was found to be useful in hydrolyzing methylprednisolone hemisuccinate to methylprednisolone.
T, Oshima, E, Nakajima, K, Hattori
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Journal of Pharmaceutical Sciences, 1981
The degradation of methylprednisolone 21-succinate in aqueous solution was examined as a function of pH at 25 degrees by monitoring the initial rates of product formation. In addition to hydrolysis, acyl migration fro the 21-hydroxyl group was found to be an important reaction.
Bradley D Anderson
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The degradation of methylprednisolone 21-succinate in aqueous solution was examined as a function of pH at 25 degrees by monitoring the initial rates of product formation. In addition to hydrolysis, acyl migration fro the 21-hydroxyl group was found to be an important reaction.
Bradley D Anderson
exaly +3 more sources