Results 11 to 20 of about 292,501 (293)

Diagnostic, Therapeutic, and Prognostic Value of the m6A Writer Complex in Hepatocellular Carcinoma

Frontiers in Cell and Developmental Biology, 2022
Hepatocellular carcinoma (HCC) has poor prognosis and is usually diagnosed only at an advanced stage. Identification of novel biomarkers is critical to early diagnosis and better prognosis for HCC patients.
Zongting Gu, Yongxing Du, Xueping Zhao, Chengfeng Wang   +3 more
doaj   +1 more source

Methyltransferases of Riboviria

Biomolecules, 2022
Many viruses from the realm Riboviria infecting eukaryotic hosts encode protein domains with sequence similarity to S-adenosylmethionine-dependent methyltransferases.
Arcady Mushegian
doaj   +1 more source

DNA methyltransferase inhibitors combination therapy for the treatment of solid tumor: mechanism and clinical application

Clinical Epigenetics, 2021
DNA methylation, an epigenetic modification, regulates gene transcription and maintains genome stability. DNA methyltransferase (DNMT) inhibitors can activate silenced genes at low doses and cause cytotoxicity at high doses.
Chunhong Hu, Xiaohan Liu, Yue Zeng, Junqi Liu, Fang Wu   +4 more
semanticscholar   +1 more source

Comprehensive analysis of transcriptome‐wide M6A methylation for hepatic ischaemia reperfusion injury in mice

Epigenetics, 2023
N6-Methyladenosine (m6A) plays key roles in the regulation of biological functions and cellular mechanisms for ischaemia reperfusion (IR) injury in different organs.
yongliang hua, xinglong Li, Bing Yin, jingjing Huang, shounan Lu, chaoqun Wang, shanjia Ke, yanan Xu, baolin Qian, zhigang Feng, hongjun Yu, yong Ma   +11 more
doaj   +1 more source

Role of WTAP in Cancer: From Mechanisms to the Therapeutic Potential

Biomolecules, 2022
Wilms’ tumor 1-associating protein (WTAP) is required for N6-methyladenosine (m6A) RNA methylation modifications, which regulate biological processes such as RNA splicing, cell proliferation, cell cycle, and embryonic development.
Yongfei Fan, Xinwei Li, Huihui Sun, Zhaojia Gao, Zheng Zhu, Kai Yuan   +5 more
doaj   +1 more source

RNA N6-Methyladenosine Modifications and Its Roles in Alzheimer’s Disease

Frontiers in Cellular Neuroscience, 2022
The importance of epitranscriptomics in regulating gene expression has received widespread attention. Recently, RNA methylation modifications, particularly N6-methyladenosine (m6A), have received marked attention.
Runjiao Zhang, Runjiao Zhang, Yizhou Zhang, Yizhou Zhang, Yizhou Zhang, Fangzhen Guo, Fangzhen Guo, Sha Li, Sha Li, Sha Li, Huixian Cui, Huixian Cui, Huixian Cui   +12 more
doaj   +1 more source

Genome-wide identification and expression pattern analysis of the SABATH gene family in Neolamarckia cadamba

Forestry Research, 2023
Plant SABATH methyltransferases are a class of enzymes that catalyze the transfer of the methyl group from S-adenosyl-L-methionine (SAM) to the carboxyl group or the nitrogen group of the substrate to form small molecule methyl esters or N-methylated ...
Rongrong Ren, Suxia Zhang, Ting Guo, Jianmei Long, Changcao Peng   +4 more
doaj   +1 more source

RNA methyltransferase METTL16: Targets and function

Wiley Interdisciplinary Reviews - RNA, 2021
The N6‐methyladenosine (m6A) RNA methyltransferase METTL16 is an emerging player in the RNA modification landscape of the human cell. Originally thought to be a ribosomal RNA methyltransferase, it has now been shown to bind and methylate the MAT2A ...
Emily R Satterwhite, K. Mansfield
semanticscholar   +1 more source

METTL16, Methyltransferase-Like Protein 16: Current Insights into Structure and Function

International Journal of Molecular Sciences, 2021
Methyltransferase-like protein 16 (METTL16) is a human RNA methyltransferase that installs m6A marks on U6 small nuclear RNA (U6 snRNA) and S-adenosylmethionine (SAM) synthetase pre-mRNA.
A. Ruszkowska
semanticscholar   +1 more source

Histone methyltransferase KMT2D targets the SPOP-G3BP1 axis to enhance AR stability and drive castration-resistant prostate cancer progression. [PDF]

Mol Biomed
Wen H, Maheremu M, Zhang K, Bao L, Luo M, Zhang Y, Liao Y, Zhou M, Wu C, Lv S, Qiu X, Wei Q.   +11 more
europepmc   +3 more sources