Results 11 to 20 of about 365,379 (338)

Role of WTAP in Cancer: From Mechanisms to the Therapeutic Potential

Biomolecules, 2022
Wilms’ tumor 1-associating protein (WTAP) is required for N6-methyladenosine (m6A) RNA methylation modifications, which regulate biological processes such as RNA splicing, cell proliferation, cell cycle, and embryonic development.
Yongfei Fan, Xinwei Li, Huihui Sun, Zhaojia Gao, Zheng Zhu, Kai Yuan   +5 more
doaj   +1 more source

RNA N6-Methyladenosine Modifications and Its Roles in Alzheimer’s Disease

Frontiers in Cellular Neuroscience, 2022
The importance of epitranscriptomics in regulating gene expression has received widespread attention. Recently, RNA methylation modifications, particularly N6-methyladenosine (m6A), have received marked attention.
Runjiao Zhang, Runjiao Zhang, Yizhou Zhang, Yizhou Zhang, Yizhou Zhang, Fangzhen Guo, Fangzhen Guo, Sha Li, Sha Li, Sha Li, Huixian Cui, Huixian Cui, Huixian Cui   +12 more
doaj   +1 more source

Genome-wide identification and expression pattern analysis of the SABATH gene family in Neolamarckia cadamba

Forestry Research, 2023
Plant SABATH methyltransferases are a class of enzymes that catalyze the transfer of the methyl group from S-adenosyl-L-methionine (SAM) to the carboxyl group or the nitrogen group of the substrate to form small molecule methyl esters or N-methylated ...
Rongrong Ren, Suxia Zhang, Ting Guo, Jianmei Long, Changcao Peng   +4 more
doaj   +1 more source

Targeting NSP16 Methyltransferase for the Broad-Spectrum Clinical Management of Coronaviruses: Managing the Next Pandemic

Diseases, 2021
With the approval and distribution of demonstrably safe COVID-19 vaccines bearing exceptionally high efficacy profiles, it may be tempting to envision a return to “normal” in the coming months.
Ilham M. Alshiraihi, Gerald L. Klein, Mark A. Brown   +2 more
doaj   +1 more source

Cytosine-to-Uracil Deamination by SssI DNA Methyltransferase [PDF]

, 2013
The prokaryotic DNA(cytosine-5)methyltransferase M.SssI shares the specificity of eukaryotic DNA methyltransferases (CG) and is an important model and experimental tool in the study of eukaryotic DNA methylation.
A Beletskii, A Jeltsch, AN Sharath, Antal Kiss, AS Yang, B Bandaru, B Bandaru, B Chaikind, BM Hall, BTF van der Gun, DM Woodcock, EA Raleigh, EU Selker, EV Koudan, G Pósfai, GL Xu, H Gowher, I Stier, Ildikó Stier, J Sambrook, JC Shen, JC Shen, JC Shen, JM Zingg, JM Zingg, KM Reinisch, LA Frederico, LM Guzman, M Frommer, M Wyszynski, Martin G. Marinus, MH Sibley, P Rathert, P Renbaum, PA Waite-Rees, PM Warnecke, R Métivier, R Shapiro, RJ Roberts, RY-H Wang, S Kumar, SE Luria, T Durfee, TA Kunkel, UT Sankpal, WA Rosche, X Cheng, X Zhang   +47 more
core   +10 more sources

Pathway of human AS3MT arsenic methylation [PDF]

, 2014
A synthetic gene encoding human As(III) S-adenosylmethionine (SAM) methyltransferase (hAS3MT) was expressed, and the purified enzyme was characterized.
Dheeman, Dharmendra S., Packianathan, Charles, Pillai, Jitesh K., Rosen, Barry P.   +3 more
core   +2 more sources

Comparative Transcriptomics for Genes Related to Berberine and Berbamine Biosynthesis in Berberidaceae

Plants, 2022
Berberine and berbamine are bioactive compounds of benzylisoquinoline alkaloids (BIAs) present in Berberis species. The contents of berbamine are 20 times higher than berberine in leaf tissues in three closely related species: Berberis koreana, B ...
Neha Samir Roy, Nam-Il Park, Nam-Soo Kim, Yeri Park, Bo-Yun Kim, Young-Dong Kim, Ju-Kyung Yu, Yong-In Kim, Taeyoung Um, Soonok Kim, Ik-Young Choi   +10 more
doaj   +1 more source

Characterisation of the androgen regulation of glycine N-methyltransferase in prostate cancer cells [PDF]

, 2013
The development and growth of prostate cancer is dependent on androgens; thus, the identification of androgen-regulated genes in prostate cancer cells is vital for defining the mechanisms of prostate cancer development and progression and developing new ...
Brinkmann, Chen, Ciara O'Hanlon-Brown, Claessens, Cleutjens, Cook, Cunha, Dai, Devos, Feldman, Greg N Brooke, Gregory, Haelens, Haelens, Ham, Heinlein, Jonathan Waxman, Laki Buluwela, Lin, Lu, Luke, Lund, Massie, Massie, Ngan, Nird  , Rennie, Rowling, Shang, Shen, Silvia Ottaviani, Simak Ali, Song, Sreekumar, Verrijdt, Wang, Yu   +36 more
core   +1 more source

Exploring the Phytochemical Landscape of the Early-Diverging Flowering Plant Amborella trichopoda Baill. [PDF]

, 2019
Although the evolutionary significance of the early-diverging flowering plant Amborella (Amborella trichopoda Baill.) is widely recognized, its metabolic landscape, particularly specialized metabolites, is currently underexplored.
Chang, Lijing, Tian, Li, Wilson, Alexander E, Wu, Sheng   +3 more
core   +1 more source

Dysregulated Choline, Methionine, and Aromatic Amino Acid Metabolism in Patients with Wilson Disease: Exploratory Metabolomic Profiling and Implications for Hepatic and Neurologic Phenotypes. [PDF]

, 2019
Wilson disease (WD) is a genetic copper overload condition characterized by hepatic and neuropsychiatric symptoms with a not well-understood pathogenesis.
Czlonkowska, Anna, Kim, Kyoungmi, Litwin, Tomasz, Mazi, Tagreed A, Medici, Valentina, Sarode, Gaurav V, Shibata, Noreene M   +6 more
core   +2 more sources