Results 11 to 20 of about 154,259 (119)
Histone H3K4 Methyltransferases as Targets for Drug-Resistant Cancers
Biology, 2021 The KMT2 (MLL) family of proteins, including the major histone H3K4 methyltransferase found in mammals, exists as large complexes with common subunit proteins and exhibits enzymatic activity.
Liu Yang, Mingli Jin, Kwang Won Jeong
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PRMT5 function and targeting in cancer
Cell Stress, 2020 Protein methyl transferases play critical roles in numerous regulatory pathways that underlie cancer development, progression and therapy-response. Here we discuss the function of PRMT5, a member of the nine-member PRMT family, in controlling oncogenic ...
Hyungsoo Kim, Ze’ev A. Ronai
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Exploration of the Activation Mechanism of the Epigenetic Regulator MLL3: A QM/MM Study
Biomolecules, 2021 The mixed lineage leukemia 3 or MLL3 is the enzyme in charge of the writing of an epigenetic mark through the methylation of lysine 4 from the N-terminal domain of histone 3 and its deregulation has been related to several cancer lines.
Sebastián Miranda-Rojas +4 more
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Forestry Research, 2023 Plant SABATH methyltransferases are a class of enzymes that catalyze the transfer of the methyl group from S-adenosyl-L-methionine (SAM) to the carboxyl group or the nitrogen group of the substrate to form small molecule methyl esters or N-methylated ...
Rongrong Ren +4 more
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Abnormality of m6A mRNA Methylation Is Involved in Alzheimer’s Disease
Frontiers in Neuroscience, 2020 Alzheimer’s disease (AD), the most common form of dementia, is highly prevalent in older adults. The main clinical feature is the progressive decline of memory function, which eventually leads to the decline of cognitive function.
Min Han +7 more
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Diseases, 2021 With the approval and distribution of demonstrably safe COVID-19 vaccines bearing exceptionally high efficacy profiles, it may be tempting to envision a return to “normal” in the coming months.
Ilham M. Alshiraihi +2 more
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Plants, 2022 Berberine and berbamine are bioactive compounds of benzylisoquinoline alkaloids (BIAs) present in Berberis species. The contents of berbamine are 20 times higher than berberine in leaf tissues in three closely related species: Berberis koreana, B ...
Neha Samir Roy +10 more
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Frontiers in Microbiology, 2017 Despite the persistent and costly problem caused by (bacterio)phage predation of Streptococcus thermophilus in dairy plants, DNA sequence information relating to these phages remains limited.
Brian McDonnell +10 more
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Role of WTAP in Cancer: From Mechanisms to the Therapeutic Potential
Biomolecules, 2022 Wilms’ tumor 1-associating protein (WTAP) is required for N6-methyladenosine (m6A) RNA methylation modifications, which regulate biological processes such as RNA splicing, cell proliferation, cell cycle, and embryonic development.
Yongfei Fan +5 more
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Methyltransferases of Riboviria
Biomolecules, 2022 Many viruses from the realm Riboviria infecting eukaryotic hosts encode protein domains with sequence similarity to S-adenosylmethionine-dependent methyltransferases.
Arcady Mushegian
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