Results 11 to 20 of about 217,730 (262)
Current Issues in Molecular Biology, 2023 Epigenetic studies on the role of DNA-modifying enzymes in HNSCC tumorigenesis have focused on a single enzyme or a group of enzymes. To acquire a more comprehensive insight into the expression profile of methyltransferases and demethylases, in the ...
Larisa Goričan +5 more
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Plants, 2022 Berberine and berbamine are bioactive compounds of benzylisoquinoline alkaloids (BIAs) present in Berberis species. The contents of berbamine are 20 times higher than berberine in leaf tissues in three closely related species: Berberis koreana, B ...
Neha Samir Roy +10 more
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A Pan-Inhibitor for Protein Arginine Methyltransferase Family Enzymes
Biomolecules, 2021 Protein arginine methyltransferases (PRMTs) play important roles in transcription, splicing, DNA damage repair, RNA biology, and cellular metabolism. Thus, PRMTs have been attractive targets for various diseases. In this study, we reported the design and
Iredia D. Iyamu +2 more
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Diagnostic, Therapeutic, and Prognostic Value of the m6A Writer Complex in Hepatocellular Carcinoma
Frontiers in Cell and Developmental Biology, 2022 Hepatocellular carcinoma (HCC) has poor prognosis and is usually diagnosed only at an advanced stage. Identification of novel biomarkers is critical to early diagnosis and better prognosis for HCC patients.
Zongting Gu +3 more
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Forestry Research, 2023 Plant SABATH methyltransferases are a class of enzymes that catalyze the transfer of the methyl group from S-adenosyl-L-methionine (SAM) to the carboxyl group or the nitrogen group of the substrate to form small molecule methyl esters or N-methylated ...
Rongrong Ren +4 more
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The DNA methyltransferases associate with HP1 and the SUV39H1 histone methyltransferase [PDF]
Nucleic Acids Research, 2003 The DNA methyltransferases, Dnmts, are the enzymes responsible for methylating DNA in mammals, which leads to gene silencing. Repression by DNA methylation is mediated partly by recruitment of the methyl-CpG-binding protein MeCP2. Recently, MeCP2 was shown to associate and facilitate histone methylation at Lys9 of H3, which is a key epigenetic ...
Fuks, François +3 more
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Epigenetics, 2023 N6-Methyladenosine (m6A) plays key roles in the regulation of biological functions and cellular mechanisms for ischaemia reperfusion (IR) injury in different organs.
yongliang hua +11 more
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PRMT5 function and targeting in cancer
Cell Stress, 2020 Protein methyl transferases play critical roles in numerous regulatory pathways that underlie cancer development, progression and therapy-response. Here we discuss the function of PRMT5, a member of the nine-member PRMT family, in controlling oncogenic ...
Hyungsoo Kim, Ze’ev A. Ronai
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Light‐Activation of DNA‐Methyltransferases [PDF]
Angewandte Chemie International Edition, 2021 Abstract5‐Methylcytosine (5mC), the central epigenetic mark of mammalian DNA, plays fundamental roles in chromatin regulation. 5mC is written onto genomes by DNA methyltransferases (DNMT), and perturbation of this process is an early event in carcinogenesis.
Jan Wolffgramm +7 more
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Abnormality of m6A mRNA Methylation Is Involved in Alzheimer’s Disease
Frontiers in Neuroscience, 2020 Alzheimer’s disease (AD), the most common form of dementia, is highly prevalent in older adults. The main clinical feature is the progressive decline of memory function, which eventually leads to the decline of cognitive function.
Min Han +7 more
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