Results 271 to 280 of about 292,501 (293)

Comparative Bioequivalence and Safety Evaluation of Ibuprofen/Phenylephrine Hydrochloride Fixed‐Dose Combination Tablets in Healthy Chinese Volunteers

Clinical Pharmacology in Drug Development, EarlyView.
Abstract This single‐center, randomized, open‐label bioequivalence program compared two fixed‐dose combination (FDC) tablets containing ibuprofen (200 mg) and phenylephrine hydrochloride (10 mg) from different manufacturers in healthy Chinese adults under fasting and fed conditions. A three‐period, partially replicated crossover design was used for the
Menghan Ye, Rui Zhang, Jing Wan, Jinping Zhou, Pengpeng Guo, Dianwen Yu, Peixia Li, Yani Liu, Shaojun Shi   +8 more
wiley   +1 more source

Unraveling Novel Genetic Determinants of Thiopurine Response Via TWAS

Clinical Pharmacology &Therapeutics, EarlyView.
Acute lymphoblastic leukemia (ALL) is the most common childhood cancer. Thiopurines such as 6‐mercaptopurine (6MP) are essential in ALL maintenance therapy. However, dose‐limiting toxicities can significantly disrupt treatment. While genetic variants in TPMT and NUDT15 are known to affect thiopurine response, many patients with normal function ...
Carlotta Bidoli, Wenjian Yang, Seth E. Karol, Marianna Lucafò, Gabriele Stocco, Jun J. Yang   +5 more
wiley   +1 more source

Epigenetic Alterations in PAH-Induced Childhood Asthma: An Intervention Using Sulforaphane. [PDF]

Toxics
Jiang X, Xu X, Hui J, Bao Y, Cao S, Wu Q.   +5 more
europepmc   +1 more source

The emerging role of Nrf2 in heart failure: From cardioprotection to therapeutic approaches

ESC Heart Failure, EarlyView.
Nrf2 signalling is impaired in heart failure, contributing to oxidative stress, mitochondrial dysfunction, and ferroptosis, which drive neurohormonal activation, inflammation, and ischaemia‐reperfusion injury. This loss of Nrf2 activity exacerbates hypertension, diabetic cardiomyopathy, and cardiotoxicity, accelerating progression to overt heart ...
Emiliano Fiori, Sergio Davinelli, Armando Ferrera, Alessandro Medoro, Carlo Barsali, Allegra Battistoni, Maurizio Volterrani, Massimo Volpe, Luciano Saso, Speranza Rubattu   +9 more
wiley   +1 more source

Implications of Indolethylamine N-Methyltransferase (INMT) in Health and Disease: Biological Functions, Disease Associations, Inhibitors, and Analytical Approaches. [PDF]

Brain Sci
Abouheif S, Awad A, McCurdy CR.
europepmc   +1 more source

Epigenotoxicity: Decoding the epigenetic imprints of genotoxic agents and their implications for regulatory genetic toxicology

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Regulatory genetic toxicology focuses on DNA damage and subsequent gene mutations. However, genotoxic agents can also affect epigenetic marks, and incorporation of epigenetic data into the regulatory framework may thus enhance the accuracy of risk assessment.
Roger Godschalk, Christopher Faulk, Jessica LaRocca, Jan van Benthem, Francesco Marchetti   +4 more
wiley   +1 more source

Exogenous application of 5-azacitidin, royal jelly and folic acid regulate plant redox state, expression level of DNA methyltransferases and alleviate adverse effects of salinity stress on Vicia faba L. plants

Samar Omar, Yingming Feng, Yu Min, Samar A Gamal Eldin, Medhat Eldenary, Sergey Shabala, Suleyman I. Allakhverdiev, Mohamed H. Abdelfattah   +7 more
openalex   +1 more source

Characterization of the nucleolar localization signal of TRMT10A and its importance for the m1G9 methylation of tRNAs in mammalian cells. [PDF]

J Mol Cell Biol
Luo T, Shi Z, Yang H, Miao J, Chang Z, Zou J, Zeng Q, Wu W, Jiang Y, Xie X, Cao L, Peng H, Li C, Guo D, Wu J.   +14 more
europepmc   +1 more source

Unveiling the Role of Histone Methyltransferases in Psoriasis Pathogenesis: Insights from Transcriptomic Analysis. [PDF]

Int J Mol Sci
Romhányi D, Bessenyei Á, Szabó K, Kemény L, Gyulai R, Groma G.   +5 more
europepmc   +1 more source

Addendum: Protein arginine methyltransferase 1 regulates B cell fate after positive selection in the germinal center in mice. [PDF]

J Exp Med
Litzler LC, Zahn A, Dionne KL, Sprumont A, Ferreira SR, Slattery MRF, Methot SP, Patenaude AM, Hébert S, Kabir N, Subramani PG, Jung S, Richard S, Kleinman CL, Di Noia JM.   +14 more
europepmc   +1 more source