Results 61 to 70 of about 175,165 (326)

DNA methyltransferases and their roles in tumorigenesis

Biomarker Research, 2017
DNA methylation plays an important role in gene expression, chromatin stability, and genetic imprinting. In mammals, DNA methylation patterns are written and regulated by DNA methyltransferases (DNMTs), including DNMT1, DNMT3A and DNMT3B. Recent emerging
Wu Zhang, Jie Xu
semanticscholar   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Networking and Specificity-Changing DNA Methyltransferases in Helicobacter pylori

Frontiers in Microbiology, 2020
Epigenetic DNA base methylation plays important roles in gene expression regulation. We here describe a gene expression regulation network consisting of many DNA methyltransferases each frequently changing its target sequence-specificity.
Hirokazu Yano, Hirokazu Yano, Md. Zobaidul Alam, Emiko Rimbara, Tomoko F. Shibata, Masaki Fukuyo, Yoshikazu Furuta, Yoshikazu Furuta, Tomoaki Nishiyama, Shuji Shigenobu, Mitsuyasu Hasebe, Mitsuyasu Hasebe, Atsushi Toyoda, Yutaka Suzuki, Sumio Sugano, Sumio Sugano, Keigo Shibayama, Ichizo Kobayashi, Ichizo Kobayashi, Ichizo Kobayashi, Ichizo Kobayashi, Ichizo Kobayashi   +21 more
doaj   +1 more source

Targets of histone H3 lysine 9 methyltransferases

Frontiers in Cell and Developmental Biology, 2022
Histone H3 lysine 9 di- and trimethylation are well-established marks of constitutively silenced heterochromatin domains found at repetitive DNA elements including pericentromeres, telomeres, and transposons. Loss of heterochromatin at these sites causes
Aidan J. Levinsky, Aidan J. Levinsky, Gregor McEdwards, Gregor McEdwards, Nasha Sethna, Nasha Sethna, Mark A. Currie, Mark A. Currie   +7 more
doaj   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

rRNA methyltransferases and their role in resistance to antibiotics [PDF]

Journal of Medical Biochemistry, 2010
Methyltransferases (MTases), a large protein superfamily, commonly use S-adenosyl-L-methionine (SAM) as the methyl group donor. SAM-dependant MTases methylate both nucleic acids (DNA, RNA) and proteins, and thus modulate their activity, function and ...
Morić Ivana, Savić Miloje, Ilić-Tomić Tatjana, Vojnović Sandra, Bajkić Sanja, Vasiljević Branka   +5 more
doaj  

Methionine Adenosyltransferase 1a (MAT1A) Enhances Cell Survival During Chemotherapy Treatment and is Associated with Drug Resistance in Bladder Cancer PDX Mice. [PDF]

, 2019
Bladder cancer is among the top ten most common cancers, with about ~380,000 new cases and ~150,000 deaths per year worldwide. Tumor relapse following chemotherapy treatment has long been a significant challenge towards completely curing cancer.
de Vere White, Ralph, Ghosh, Paramita M, He, Wei, Hum, Nicholas R, Loots, Gabriela G, Martin, Kelly A, Pan, Chong-Xian, Sebastian, Aimy, Siddiqui, Salma   +8 more
core   +2 more sources

A chemical biology toolbox to study protein methyltransferases and epigenetic signaling

Nature Communications, 2019
Protein methyltransferases (PMTs) comprise a major class of epigenetic regulatory enzymes with therapeutic relevance. Here we present a collection of chemical probes and associated reagents and data to elucidate the function of human and murine PMTs in ...
Sebastian Scheer, S. Ackloo, T. Medina, M. Schapira, M. Schapira, Fengling Li, Jennifer A. Ward, Jennifer A. Ward, Andrew M. Lewis, Andrew M. Lewis, J. Northrop, P. Richardson, H. Kaniskan, Yudao Shen, Jing Liu, D. Smil, Dave McLeod, C. Zepeda-Velázquez, Minkui Luo, Minkui Luo, Jian Jin, Dalia Barsyte-Lovejoy, Kilian V. M. Huber, Kilian V. M. Huber, D. D. Carvalho, D. D. Carvalho, M. Vedadi, M. Vedadi, C. Zaph, P. Brown, Cheryl H. Arrowsmith, Cheryl H. Arrowsmith, Cheryl H. Arrowsmith   +32 more
semanticscholar   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Inhibitors of Protein Methyltransferases and Demethylases

Chemical Reviews, 2017
Post-translational modifications of histones by protein methyltransferases (PMTs) and histone demethylases (KDMs) play an important role in the regulation of gene expression and transcription and are implicated in cancer and many other diseases.
H. Kaniskan, Michael L. Martini, Jian Jin   +2 more
semanticscholar   +1 more source