Results 101 to 110 of about 680,163 (298)

Resolvability in Hypergraphs

open access: yes, 2018
This article emphasizes an extension of the study of metric and par- tition dimension to hypergraphs. We give a sharp lower bounds for the metric and partition dimension of hypergraphs in general and give exact values under specified conditions.eral and ...
Haider, Azeem   +3 more
core  

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

open access: yesMolecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller   +17 more
wiley   +1 more source

Vertex and edge resolvability of some drug structures

open access: yesResults in Chemistry
Distance-based parameters are crucial in studying drug structures as they help in uniquely identifying and characterizing the molecular structure through the analysis of graph representations, thereby aiding in the understanding of molecular properties ...
Ayesha Andalib Kiran   +3 more
doaj   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola   +12 more
wiley   +1 more source

The metric dimension of circulant graphs [PDF]

open access: yesOpuscula Mathematica
A pair of vertices \(x\) and \(y\) in a graph \(G\) are said to be resolved by a vertex \(w\) if the distance from \(x\) to \(w\) is not equal to the distance from \(y\) to \(w\).
Tapendra BC, Shonda Dueck
doaj   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

open access: yesMolecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone   +11 more
wiley   +1 more source

Nonequality of dimensions for metric spaces [PDF]

open access: yesTransactions of the American Mathematical Society, 1968
and Ind (S) = n if Ind (S)^n but Ind (S)Sn-l is not true. Covering dimension (=Lebesgue covering dimension), denoted by dim such that dim (S) = 1 if S is empty, dim (S) S n if every finite open cover of S has a finite open refining cover of order ^n+1, that is, no point of S belongs to more than n -I-1 members of the refinement, and dim (S)=n if dim (S)
openaire   +2 more sources

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