Results 111 to 120 of about 654,066 (314)

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

open access: yesMolecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau   +11 more
wiley   +1 more source

Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry

open access: yesMolecular Oncology, EarlyView.
Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson   +11 more
wiley   +1 more source

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

open access: yesMolecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani   +14 more
wiley   +1 more source

Nonequality of dimensions for metric groups

open access: yesTopology and its Applications, 2008
An embeddability criterion for zero-dimensional metrizable topological spaces in zero-dimensional metrizable topological groups is given. A space which can be embedded as a closed subspace in a zero-dimensional metrizable group but is not strongly zero-dimensional is constructed; thereby, an example of a metrizable group with noncoinciding dimensions ...
openaire   +3 more sources

Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence

open access: yesMolecular Oncology, EarlyView.
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova   +18 more
wiley   +1 more source

On the metric dimension of line graphs

open access: yesDiscrete Applied Mathematics, 2013
Let $G$ be a (di)graph. A set $W$ of vertices in $G$ is a \emph{resolving set} of $G$ if every vertex $u$ of $G$ is uniquely determined by its vector of distances to all the vertices in $W$. The \emph{metric dimension} $ (G)$ of $G$ is the minimum cardinality of all the resolving sets of $G$. C ceres et al. \cite{Ca2} computed the metric dimension of
Min Xu, Min Feng, Kaishun Wang
openaire   +3 more sources

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