Results 111 to 120 of about 691,381 (299)

The metric dimension of circulant graphs [PDF]

open access: yesOpuscula Mathematica
A pair of vertices \(x\) and \(y\) in a graph \(G\) are said to be resolved by a vertex \(w\) if the distance from \(x\) to \(w\) is not equal to the distance from \(y\) to \(w\).
Tapendra BC, Shonda Dueck
doaj   +1 more source

Screening for lung cancer: A systematic review of overdiagnosis and its implications

open access: yesMolecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz   +12 more
wiley   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

open access: yesMolecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir   +12 more
wiley   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

open access: yesMolecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed   +10 more
wiley   +1 more source

A valent-based metric framework for analyzing intuitionistic fuzzy graphs in uncertain environments

open access: yesAin Shams Engineering Journal
This paper introduces a new notion of distance in intuitionistic fuzzy graphs, termed the Valent distance, which incorporates the degrees (valences) of both vertices and edges.
J. Komathi, D. Meiyappan, K. Anitha
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

open access: yesMolecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son   +13 more
wiley   +1 more source

Metric and strong metric dimension in TI-power graphs of finite groups

open access: yesAIMS Mathematics
Given a finite group $ G $ with the identity $ e $, the TI-power graph (trivial intersection power graph) of $ G $ is an undirected graph with vertex set $ G $, in which two distinct vertices $ x $ and $ y $ are adjacent if $ \langle x\rangle\cap \langle
Chunqiang Cui, Jin Chen, Shixun Lin
doaj   +1 more source

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