Results 81 to 90 of about 282,648 (277)

A remark on positive topological entropy of N-buffer switched flow networks

open access: yesDiscrete Dynamics in Nature and Society, 2005
We present a simpler elementary proof on positive topological entropy of the N-buffer switched flow networks based on a new simple theorem on positive topological entropy of continuous map on compact metric space.
Xiao-Song Yang
doaj   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

open access: yesMolecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff   +11 more
wiley   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

open access: yesMolecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala   +15 more
wiley   +1 more source

Large Alphabets and Incompressibility

open access: yes, 2006
We briefly survey some concepts related to empirical entropy -- normal numbers, de Bruijn sequences and Markov processes -- and investigate how well it approximates Kolmogorov complexity. Our results suggest $\ell$th-order empirical entropy stops being a
Becher   +21 more
core   +2 more sources

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

open access: yesMolecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung   +17 more
wiley   +1 more source

Algorithm for Efficient Entropy Estimation

open access: yesМоделирование и анализ информационных систем, 2013
We consider the problem of the nonparametric entropy estimation of a stationary ergodic process. Our approach is based on the nearest-neighbor distances. We propose a broad class of metrics on the space Ω = AN of right-sided infinite sequences drawn from
E. A. Timofeev
doaj   +3 more sources

From Barcode Entropy to Metric Entropy

open access: yes
18 ...
Cineli, Erman   +2 more
openaire   +2 more sources

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

open access: yesMolecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang   +3 more
wiley   +1 more source

Corrections to de Sitter entropy through holography

open access: yesPhysics Letters B, 2020
The holographic entanglement entropy is computed for an entangling surface that coincides with the horizon of a boundary de Sitter metric. This is achieved through an appropriate slicing of anti-de Sitter space and the implementation of a UV cutoff.
N. Tetradis
doaj   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

open access: yesMolecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal   +4 more
wiley   +1 more source

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