Results 71 to 80 of about 282,648 (277)
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Transaction Entropy: An Alternative Metric of Market Performance
Entropy, 2023 Market uncertainty has a significant impact on market performance. Previous studies have dedicated much effort towards investigations into market uncertainty related to information asymmetry and risk. However, they have neglected the uncertainty inherent
Hua Zhong, Xiaohao Liang, Yougui Wang
doaj +1 more source
Geometric model of black hole quantum $N$-portrait, extradimensions and thermodynamics
, 2016 Recently a short scale modified black hole metric, known as holographic metric, has been proposed in order to capture the self-complete character of gravity. In this paper we show that such a metric can reproduce some geometric features expected from the
Frassino, Antonia M. +2 more
core +2 more sources
Duality of metric entropy in Euclidean space [PDF]
Comptes Rendus. Mathématique, 2003 Let K be a convex body in a Euclidean space, K° its polar body and D the Euclidean unit ball. We prove that the covering numbers N(K,tD) and N(D,tK°) are comparable in the appropriate sense, uniformly over symmetric convex bodies K, over t>0 and over the dimension of the space.
Artstein, Shiri +2 more
openaire +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Use and Abuse of Entropy in Biology: A Case for Caliber
Entropy, 2020 Here, I discuss entropy and its use as a tool in fields of biology such as bioenergetics, ecology, and evolutionary biology. Statistical entropy concepts including Shannon’s diversity, configurational entropy, and informational entropy are discussed in ...
Ty N. F. Roach
doaj +1 more source
Magnetic flows on Sol-manifolds: dynamical and symplectic aspects
, 2008 We consider magnetic flows on compact quotients of the 3-dimensional solvable geometry Sol determined by the usual left-invariant metric and the distinguished monopole.
A. Hattori +14 more
core +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Entropy Rigidity of Hilbert and Riemannian Metrics [PDF]
International Mathematics Research Notices, 2016 In this paper we provide two new characterizations of real hyperbolic $n$-space using the Poincar exponent of a discrete group and the volume growth entropy. The first characterization is in the space of Hilbert metrics and generalizes a result of Crampon.
Barthelmé, Thomas +2 more
openaire +3 more sources
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source