Results 101 to 110 of about 396,215 (311)
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
SEMICONTINUITY OF METRIC PROJECTIONS IN $c_0$-DIRECT SUMS [PDF]
, 2006 S. Lalithambigai, Darapaneni Narayana
openalex +1 more source
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Squintability and Other Metrics for Assessing Projection Pursuit Indexes, and Guiding Optimization Choices [PDF]
H. Sherry Zhang +3 more
openalex +2 more sources
Modeling Practical Multi-Center-of-Projection Using Ellipsoid
IEEE AccessTraditional 3D projection models, such as perspective and orthographic projection, are limited to two types of projective ray fields: rays passing through a single point and parallel rays.
Soohyun Lee, Junyoung Yoon, Joo Ho Lee
doaj +1 more source
Hölder Continuity of a Parametric Generalized Variational Inequality
Abstract and Applied Analysis, 2014 By using the classic metric projection method, we obtain sufficient conditions for Hölder continuity of the nonunique solution mapping for a parametric generalized variational inequality with respect to data perturbation. The result is different from the
Li-na Wang, Xiao-bing Li
doaj +1 more source
Focusing on Project Metrics [PDF]
, 2017 The need to ensure that scarce funding is applied to effective projects is a goal shared by all. Focusing on common parameters of project performance is a means to that end.
openaire +1 more source
Measurable selectors for the metric projection [PDF]
, 2003 B. Cascales, M. Raja
openalex +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source