Results 111 to 120 of about 234,437 (318)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

partial translation algebras for certain discrete metric spaces

open access: yes, 2010
The notion of a partial translation algebra was introduced by Brodzki, Nibloand Wright in [11] to provide an analogue of the reduced group C*-algebrafor metric spaces.
Putwain, Rosemary Johanna
core  

Metric in Feature Space [PDF]

open access: yes, 2009
In this paper our purpose is to define a metric in feature space. The metric finds the correlation distance between two features. It may be used in many applications. An application showing the utility of the proposed metric for feature selection is described here.
C. A. Murthy, Sourav Pradhan
openaire   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

open access: yesMolecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski   +10 more
wiley   +1 more source

Interpreting the C-metric [PDF]

open access: yes, 2006
The basic properties of the C-metric are well known. It describes a pair of causally separated black holes which accelerate in opposite directions under the action of forces represented by conical singularities.
P. Krtous (7160315)   +2 more
core  

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

open access: yesMolecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski   +12 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

The least doubling constant of a metric measure space

open access: yes, 2019
We study the least doubling constant C(X,d), among all doubling measures µ supported on a metric space (X, d). In particular, we prove that for every metric space with more than one point, C(X,d) ≥ 2.
Soria de Diego, Francisco Javier   +2 more
core   +1 more source

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