Results 121 to 130 of about 6,611,973 (350)

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

open access: yesFEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu   +17 more
wiley   +1 more source

On the space of Riemannian metrics [PDF]

open access: yesBulletin of the American Mathematical Society, 1968
1. Results. In the present announcement we are concerned with the space of Riemannian metrics on a compact smooth manifold. Let M be such a manifold, 5T* the bundle of symmetric covariant twotensors on Mf and C°°(S T*) the smooth sections of this bundle, endowed with the C topology.
openaire   +3 more sources

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

open access: yesFEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan   +2 more
wiley   +1 more source

Rectangular cone b-metric spaces over Banach algebra and contraction principle

open access: yesFixed Point Theory and Applications, 2017
Rectangular cone b-metric spaces over a Banach algebra are introduced as a generalization of metric space and many of its generalizations. Some fixed point theorems are proved in this space and proper examples are provided to establish the validity and ...
Reny George   +4 more
doaj   +1 more source

The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1

open access: yesFEBS Letters, EarlyView.
MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson   +7 more
wiley   +1 more source

On Parametric S-Metric Spaces and Fixed-Point Type Theorems for Expansive Mappings

open access: yesJournal of Mathematics, 2016
We introduce the notion of a parametric S-metric space as generalization of a parametric metric space. Using some expansive mappings, we prove a fixed-point theorem on a parametric S-metric space.
Nihal Taş, Nihal Yılmaz Özgür
doaj   +1 more source

A generalization of Banachs contraction principle for nonlinear contraction in a partial metric space

open access: yes, 2012
We establish a fixed point theorem for nonlinear contraction in a complete partial metric space. Our result generalizes the Banach type fixed point theorem in a partial metric space in the sense of Matthews. c ©2012 NGA. All rights reserved.
W. Shatanawi, H. Nashine
semanticscholar   +1 more source

Mycobacterium tuberculosis sulfurtransferase SseA is activated by its neighboring gene product Rv3284

open access: yesFEBS Letters, EarlyView.
Tuberculosis remains a global health challenge and new therapeutic targets are required. Here, we characterized SseA, a sulfurtransferase from Mycobacterium tuberculosis involved in macrophage infection, and its interaction with the newly identified protein SufEMtb that activates SseA enzymatic activity.
Giulia Di Napoli   +10 more
wiley   +1 more source

Balls in generalizations of metric spaces

open access: yesJournal of Inequalities and Applications, 2016
This paper discusses balls in partial b-metric spaces and cone metric spaces, respectively. Let ( X , p b ) $(X,p_{b})$ be a partial b-metric space in the sense of Mustafa et al. For the family △ of all p b $p_{b}$ -open balls in ( X , p b ) $(X,p_{b})$ ,
Xun Ge, Shou Lin
doaj   +1 more source

Fixed Point Theorems in $ b$-Rectangular Metric Spaces

open access: yesUniversal Journal of Mathematics and Applications, 2020
The concept of $ b$-rectangular metric space is introduced as a generalization of $ b $-metric space and rectangular (generalized) metric space. In this paper, we introduce generalized almost contraction for two mappings and prove common fixed point ...
Vildan Öztürk
doaj   +1 more source

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