Results 121 to 130 of about 6,713,503 (368)

Structural dynamics of the plant hormone receptor ETR1 in a native‐like membrane environment

FEBS Letters, EarlyView.
The present study unveils the structural and signaling dynamics of ETR1, a key plant ethylene receptor. Using an optimized nanodisc system and solution NMR, we captured full‐length ETR1 in a native‐like membrane environment. Our findings reveal dynamic domain uncoupling and Cu(I)‐induced rigidification, providing the first evidence of metal‐triggered ...
Moritz Lemke, Nils Alexander Lakomek, Georg Groth   +2 more
wiley   +1 more source

Mechanistic basis for inhibition of the extended‐spectrum β‐lactamase GES‐1 by enmetazobactam and tazobactam

FEBS Letters, EarlyView.
Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer, Philip Hinchliffe, Marko Hanževački, Christopher R. Bethel, Catherine L. Tooke, Marc W. Van der Kamp, Krisztina M. Papp‐Wallace, Robert A. Bonomo, Stuart Shapiro, Adrian J. Mulholland, James Spencer   +10 more
wiley   +1 more source

Fixed point theorems in a new type of modular metric spaces

Fixed Point Theory and Applications, 2018
In this paper, considering both a modular metric space and a generalized metric space in the sense of Jleli and Samet (Fixed Point Theory Appl. 2015:61, 2015), we introduce a new concept of generalized modular metric space.
Duran Turkoglu, Nesrin Manav
doaj   +1 more source

Approximation and Schur properties for Lipschitz free spaces over compact metric spaces

, 2015
We prove that for any separable Banach space $X$, there exists a compact metric space which is homeomorphic to the Cantor space and whose Lipschitz-free space contains a complemented subspace isomorphic to $X$.
Hájek, Petr, Lancien, Gilles, Pernecká, Eva   +2 more
core  

Networklike metric spaces

Discrete Mathematics, 1988
The author deals with the comparison of the following two fundamental metrical properties of a network: (a) it is a tree if and only if its metric is convex, and (b) it decomposes into finitely many treelike segments on which the metric is convex.
openaire   +2 more sources

From lactation to malignancy: A comparison between healthy and cancerous breast gland at single‐cell resolution reveals new issues for tumorigenesis

FEBS Letters, EarlyView.
Single‐cell RNA sequencing reveals an opposite role of SLPI in basal tumors based on metastatic spread, along with shared activation of specific regulons in cancer cells and mature luminal lactocytes, as well as downregulation of MALAT1 and NEAT1 in the latter.
Pietro Ancona, Carlo M. Bergamini, Carlo Ferrari, Stefano Volinia, Nicoletta Bianchi   +4 more
wiley   +1 more source

Fixed Point Results for Nonlinear F-Contractions in Composed S-Metric Spaces

Journal of Function Spaces
In this paper, we introduce the concept of composed S-metric space as a new generalization of S-metric space and Sb-metric space. We present some examples showing that a composed S-metric space is a generalization of various types of abstract spaces, and
Chol Jin Kil, Jong-Chol Choe, Un-Ryong Rim   +2 more
doaj   +1 more source

Neutrosophic Triplet v-Generalized Metric Space

Axioms, 2018
The notion of Neutrosophic triplet (NT) is a new theory in Neutrosophy. Also, the v-generalized metric is a specific form of the classical metrics. In this study, we introduced the notion of neutrosophic triplet v-generalized metric space (NTVGM), and we
Memet Şahin, Abdullah Kargın
doaj   +1 more source

Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells

FEBS Letters, EarlyView.
Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura, Lixiang Wang, Nao Hasuzawa, Ayako Nagayama, Sawako Moriyama, Kenji Ashida, Yoshinori Moriyama, Masatoshi Nomura, Ken Yamamoto   +8 more
wiley   +1 more source

Ultrametricity and metric betweenness in tangent spaces to metric spaces

P-Adic Numbers, Ultrametric Analysis, and Applications, 2010
The paper deals with pretangent spaces to general metric spaces. An ltrametricity criterion for pretangent spaces is found and it is closely related to the metric betweenness in the pretangent spaces.
Dmytro Dordovskyi, Oleksiy Dovgoshey
openaire   +3 more sources