Results 81 to 90 of about 642,101 (319)

Circulating tumor cells in metastatic breast cancer patients treated with immune checkpoint inhibitors – a biomarker analysis of the ALICE and ICON trials

open access: yesMolecular Oncology, EarlyView.
In this explorative biomarker analysis, we assessed serial sampling of circulating tumor cells (CTCs) with CellSearch in two randomized trials testing immune checkpoint inhibitors (ICIs) in metastatic breast cancer. Our data demonstrate a prognostic potential of CTCs, most apparent 4 weeks into ICI therapy.
Nikolai Kragøe Andresen   +13 more
wiley   +1 more source

Ultrafilters on metric spaces

open access: yesTopology and its Applications, 2014
Let $X$ be an unbounded metric space, $B(x,r) = \{y\in X: d(x,y) \leqslant r\}$ for all $x\in X$ and $r\geqslant 0$. We endow $X$ with the discrete topology and identify the Stone- ech compactification $ X$ of $X$ with the set of all ultrafilters on $X$.
openaire   +3 more sources

Combined spatially resolved metabolomics and spatial transcriptomics reveal the mechanism of RACK1‐mediated fatty acid synthesis

open access: yesMolecular Oncology, EarlyView.
The authors analyzed the spatial distributions of gene and metabolite profiles in cervical cancer through spatial transcriptomic and spatially resolved metabolomic techniques. Pivotal genes and metabolites within these cases were then identified and validated.
Lixiu Xu   +3 more
wiley   +1 more source

Fixed point theorems in a new type of modular metric spaces

open access: yesFixed Point Theory and Applications, 2018
In this paper, considering both a modular metric space and a generalized metric space in the sense of Jleli and Samet (Fixed Point Theory Appl. 2015:61, 2015), we introduce a new concept of generalized modular metric space.
Duran Turkoglu, Nesrin Manav
doaj   +1 more source

Continuous and Uniform Continuous Mappings on a Standard Fuzzy Metric Spaces [PDF]

open access: yesEngineering and Technology Journal, 2014
In this paper we introduced the definition of standard fuzzy metric spaces then we discussed several properties of this space after some illustrative examples are given. Then we defined a continuous mapping from standard fuzzy metric space (X,M_X,*) into
Jehad R.Kider, Zeina A.Hussain
doaj   +1 more source

Addressing persistent challenges in digital image analysis of cancer tissue: resources developed from a hackathon

open access: yesMolecular Oncology, EarlyView.
Large multidimensional digital images of cancer tissue are becoming prolific, but many challenges exist to automatically extract relevant information from them using computational tools. We describe publicly available resources that have been developed jointly by expert and non‐expert computational biologists working together during a virtual hackathon
Sandhya Prabhakaran   +16 more
wiley   +1 more source

Test Spaces for Metric Spaces [PDF]

open access: yesProceedings of the American Mathematical Society, 1959
Introduction. Let n be a positive integer, and let yn be a topological space with the following property: a topological space X has dimension Yn can be extended over X. Then we call yn a test space for dimension n. In a previous paper [10], we characterized test spaces for dimension n under the assumption that both X and yn were separable metric.
openaire   +2 more sources

Etoposide‐induced cancer cell death: roles of mitochondrial VDAC1 and calpain, and resistance mechanisms

open access: yesMolecular Oncology, EarlyView.
The complex mode of action of the topoisomerase II inhibitor etoposide in triggering apoptosis involves several mechanisms: overexpression of the mitochondrial protein VDAC1, leading to its oligomerization and formation of a large channel that mediates the release of pro‐apoptotic protein; and overexpression of the apoptosis regulators p53, Bax, and ...
Aditya Karunanithi Nivedita   +1 more
wiley   +1 more source

Trimming of finite metric spaces [PDF]

open access: yesarXiv, 2016
We define a class of trim metric spaces and show that every finite metric space is the leaf space of a metric forest with trim base.
arxiv  

Metric properties of Outer Space [PDF]

open access: yesPublicacions Matemàtiques, 2011
We define metrics on Culler-Vogtmann space, which are an analogue of the Teichmuller metric and are constructed using stretching factors. In fact the metrics we study are related, one being a symmetrised version of the other. We investigate the basic properties of these metrics, showing the advantages and pathologies of both choices.
FRANCAVIGLIA, STEFANO, A. Martino
openaire   +9 more sources

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