LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
MathematicsDefining an adequate unit size is often crucial in brain imaging analysis, where datasets are complex, high-dimensional, and computationally demanding. Unit size refers to the spatial resolution at which brain data is aggregated for analysis.
Jihnhee Yu, HyunAh Lee, Zohi Sternberg
doaj +1 more source
How to measure endoscopy unit performance: some metrics for dummies [PDF]
, 2016 Vignesh Muthusamy
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Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
On the boundary behavior of the holomorphic sectional curvature of the Bergman metric
Le Matematiche, 2006 We obtain a conceptually new differential geometric proof of P. F. Klembeck’s result (cf. [9]) that the holomorphic sectional curvature k g (z ) of the Bergman metric of a strictly pseudoconvex domain Ω ⊂ ℂ n approaches −4/(n + 1 ...
Elisabetta Barletta
doaj
Discrepancies between Retrospective Review of “Real-Time” Electronic Health Record Documentation and Prospective Observer Documentation of In-Hospital Cardiac Arrest Quality Metrics in an Academic Cardiac Intensive Care Unit [PDF]
, 2023 Nicholas A. Morris +5 more
openalex +1 more source
Molecular Oncology, EarlyView.To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley +1 more source
Designing a TPMS metamaterial via deep learning and topology optimization
Frontiers in Mechanical EngineeringData-driven models that act as surrogates for computationally costly 3D topology optimization techniques are very popular because they help alleviate multiple time-consuming 3D finite element analyses during optimization.
Asha Viswanath +5 more
doaj +1 more source
Acoustic metrics to assess humpback whale song unit structure from the Atlantic sector of the Southern ocean [PDF]
, 2021 Elena Schall +2 more
openalex +1 more source