Results 81 to 90 of about 5,269,237 (355)

Analyzing and Comparing Biomass Feedstock Supply Systems in China: Corn Stover and Sweet Sorghum Case Studies

open access: yesEnergies, 2015
This paper analyzes the rural Chinese biomass supply system and models supply chain operations according to U.S. concepts of logistical unit operations: harvest and collection, storage, transportation, preprocessing, and handling and queuing.
Lantian Ren   +6 more
doaj   +1 more source

Mechanistic basis for inhibition of the extended‐spectrum β‐lactamase GES‐1 by enmetazobactam and tazobactam

open access: yesFEBS Letters, EarlyView.
Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer   +10 more
wiley   +1 more source

C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules

open access: yesFEBS Letters, EarlyView.
Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican   +7 more
wiley   +1 more source

On the Classifying of the Tangent Sphere Bundle with Almost Contact B-Metric Structure

open access: yesپژوهش‌های ریاضی, 2021
One of the classical fundamental motifs in differential geometry of manifolds is the notion of the almost contact structure. As a counterpart of the almost contact metric structure, the notion of the almost contact B-metric structure has been an ...
Esmaeil Peyghan, Farshad Firuzi
doaj  

Almost Ricci–Yamabe soliton on contact metric manifolds [PDF]

open access: yesArab Journal of Mathematical Sciences
Purpose – This paper aims to study almost Ricci–Yamabe soliton in the context of certain contact metric manifolds. Design/methodology/approach – The paper is designed as follows: In Section 3, a complete contact metric manifold with the Reeb vector field
Mohan Khatri, Jay Prakash Singh
doaj   +1 more source

The visual angle metric and quasiregular maps [PDF]

open access: yes, 2015
The distortion of distances between points under maps is studied. We rst prove a Schwarz-type lemma for quasiregular maps of the unit disk involving the visual angle metric.
Gendi Wang, M. Vuorinen
semanticscholar   +1 more source

From lactation to malignancy: A comparison between healthy and cancerous breast gland at single‐cell resolution reveals new issues for tumorigenesis

open access: yesFEBS Letters, EarlyView.
Single‐cell RNA sequencing reveals an opposite role of SLPI in basal tumors based on metastatic spread, along with shared activation of specific regulons in cancer cells and mature luminal lactocytes, as well as downregulation of MALAT1 and NEAT1 in the latter.
Pietro Ancona   +4 more
wiley   +1 more source

A Metric Space with LCOE Isolines for Research Guidance in wind and hydrokinetic energy systems

open access: yesWind Energy, 2020
This paper introduces a new Metric Space to guide the design of advanced wind energy systems and hydrokinetic energy converters such as tidal, ocean current and riverine turbines.
Mario Garcia‐Sanz
doaj   +1 more source

Cancer cell death induced by the NAD antimetabolite Vacor discloses the antitumor potential of SARM1

open access: yesFEBS Letters, EarlyView.
Vacor, a compound converted into the toxic metabolite Vacor adenine dinucleotide (VAD) by the nicotinamide salvage pathway enzymes NAMPT and NMNAT2, exhibits antitumor activity by inducing rapid and complete NAD depletion. We report that Vacor toxicity is limited to cell lines expressing high levels of SARM1, a NAD glycohydrolase.
Giuseppe Ranieri   +5 more
wiley   +1 more source

Antimicrobial Use Over a Four-Year Period Using Days of Therapy Measurement at a Canadian Pediatric Acute Care Hospital

open access: yesCanadian Journal of Infectious Diseases and Medical Microbiology, 2015
BACKGROUND: Antimicrobial resistance is a concern that is challenging the ability to treat common infections. Surveillance of antimicrobial use in pediatric acute care institutions is complicated because the common metric unit, the defined daily dose, is
Bruce R Dalton   +6 more
doaj   +1 more source

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