Results 11 to 20 of about 596,809 (161)

FORMULATION AND EVALUATION OF METRONIDAZOLE MICROSPHERES-LOADED BIOADHESIVE VAGINAL GEL [PDF]

Asian Journal of Pharmaceutical and Clinical Research, 2017
ABSTRACTObjectives: The objective of the present work is to develop and characterize metronidazole microsphere-loaded bioadhesive vaginal gel to ensurelonger residence time at the infection site, providing a favorable release profile for the drug.Methods: Microsphere was prepared by solvent evaporation method in various ratios of metronidazole to poly ...
Banasmita Kalita, Kritika Saikia, Bhupen Kalita   +2 more
core   +5 more sources

DEVELOPMENT OF METRONIDAZOLE MICROSPONGE INCORPORATED INTO CARBOMER-BASED VAGINAL GEL [PDF]

Journal of Experimental Biology and Agricultural Sciences, 2021
Bacterial vaginosis (BV) is a vaginal infection caused by excessive bacterial growth, thus disrupting the natural balance of bacteria inside the vagina. Metronidazole becomes a drug of choice and a widely prescribed drug for the treatment of BV. However, when applied topically, metronidazole has a low vaginal residence time because of the natural ...
Sandra Aulia Mardikasari, Arfian Junior Amir, Aliyah ., Muhammad Nur Amir, Achmad Himawan, Usmanengsih ., Suci Ananda Putri, Irma Nurfadilla Tuany, Andi Dian Permana   +8 more
openaire   +2 more sources

Comparing the effect of sucrose gel and metronidazole gel in treatment of clinical symptoms of bacterial vaginosis: a randomized controlled trial

Trials, 2018
Background Lactobacilli, as normal vaginal flora, have a central role in controlling body environment and preventing the growth of pathogens. Sucrose, by promoting the growth of Lactobacilli, accelerates the suppression of pathogenic bacteria. The aim of
Somayyeh Khazaeian, Ali Navidian, Shahin-dokht Navabi-Rigi, Marzieh Araban, Faraz Mojab, Safoura Khazaeian   +5 more
doaj   +2 more sources

Development of Thermoresponsive Hydrogels with Mucoadhesion Properties Loaded with Metronidazole Gel-Flakes for Improved Bacterial Vaginosis Treatment

Pharmaceutics, 2023
Bacterial vaginosis is an infectious disease that has significantly affected women’s health. Metronidazole has been widely used as a drug for treating bacterial vaginosis.
Andi Dian Permana, Rangga Meidianto Asri, Muhammad Nur Amir, Achmad Himawan, Andi Arjuna, Nana Juniarti, Rifka Nurul Utami, Sandra Aulia Mardikasari   +7 more
doaj   +2 more sources

Lactic acid gel versus metronidazole for recurrent bacterial vaginosis in women aged 16 years and over: the VITA RCT [PDF]

Health Technology Assessment, 2022
Background: Bacterial vaginosis is a common and distressing condition associated with serious comorbidities. Antibiotic treatment is usually clinically effective in the short term, but recurrence is common and side effects can occur.
Lindsay Armstrong-Buisseret, Clare Brittain, Joe Kai, Miruna David, Jocelyn Anstey Watkins, Mara Ozolins, Louise Jackson, Zainab Abdali, Trish Hepburn, Frances Griffiths, Alan Montgomery, Jane Daniels, Alice Manley, Gillian Dean, Jonathan DC Ross   +14 more
doaj   +4 more sources

Compare the effect of vaginal cream hydroalcoholic extracts of oregano (Mentha longifolia L.), mint (Mentha piperata L.) and savory (Satureja hortensis L.) with metronidazole vaginal gel in the treatment of Bacterial vaginosis [PDF]

International Pharmacy Acta, 2018
Abstract: Bacterial vaginosis is caused by an overgrowth of anaerobic bacteria. And a common complication of the vagina in women of childbearing age and cause premature rupture of membranes labor pain, premature birth and infant and often accompanied by secretions thin, smooth, gray and with a bad smell fish, that vaginal mucosa to form of uniform ...
Eghbal, Hojjat, Moazzenzadeh, Omid, Mohammadi, Elshan, Feyzi, Samaneh   +3 more
openaire   +2 more sources

Randomized clinical trial comparing the efficacy of the vaginal use of metronidazole with a Brazilian pepper tree (Schinus) extract for the treatment of bacterial vaginosis

Brazilian Journal of Medical and Biological Research, 2011
A 7.4% vaginal extract of the Brazilian pepper tree (Schinus terebinthifolius Raddi) was compared with 0.75% vaginal metronidazole, both manufactured by the Hebron Laboratory, for the treatment of bacterial vaginosis, used at bedtime for 7 nights.
S.R.R.F. Leite, M.M.R. Amorim, P.F.B. Sereno, T.N.F. Leite, J.A.C. Ferreira, R.A.A. Ximenes   +5 more
doaj   +3 more sources

The Impact of the Vaginal Microbiome and Microbial Metabolites on HIV Transmission at the Female Reproductive Tract Epithelial Barrier. [PDF]

Am J Reprod Immunol
ABSTRACT Despite major advances in biomedical HIV prevention strategies, almost 50% of the 1.3 million new HIV infections in 2024 occurred in women and girls through heterosexual transmission. Choice in HIV prevention modalities is needed throughout a women's lifespan to increase pre‐exposure prophylaxis uptake; however, there is a paucity of topical ...
Jesaveluk B, Ellenberg P, Hearps AC, Tachedjian G.   +3 more
europepmc   +2 more sources

Breaking Physiological Barriers in Women's Health: Mucoadhesive and Stimuli-Responsive Nanomaterials. [PDF]

Wiley Interdiscip Rev Nanomed Nanobiotechnol
Drug delivery vehicles generated from biomaterials for women's health. In particular, the breast and the reproductive system, including the ovary, uterus, cervix, vagina, and the surrounding tissues, targeted drug delivery. BioRender. ABSTRACT Biomaterials are natural or synthetic molecules that exhibit biocompatibility, biodegradability, or ...
Parsons M, Parker AR, Schneider L, Sullivan T, Givens BE.   +4 more
europepmc   +2 more sources

Research Progress in the Treatment of Vaginitis With Bioactive Compounds: Targeting of Vaginal Microflora. [PDF]

Microbiologyopen
Mechanism diagram of the effect of herbal medicine on vaginitis. Herbal medicines mainly combat vaginitis by (A) inhibiting bacteria, (B) inhibiting fungi, (C) acting on the cilia of Trichomonas, (D) inhibiting virus replication, (E) repairing the mucosa, (F) enhancing immunity, and (G) maintaining the microecological balance.
Li Y, Liu H, Li R, Li R, Liu J.
europepmc   +2 more sources