Results 31 to 40 of about 596,809 (161)

Microbicides Development Programme: design of a phase III trial to measure the efficacy of the vaginal microbicide PRO 2000/5 for HIV prevention [PDF]

, 2009
With 2.5 million new HIV infections per year, effective preventive methods against HIV are urgently needed, especially in sub-Saharan Africa. MDP301 is an ongoing trial of the vaginal microbicide PRO 2000/5 being conducted by the Microbicides Development
Pool, Robert, Nunn, A., Pool, R, Nunn, A, Hayes Richard, Sheena McCormack, Rutterford, Clare, McCormack, S, Crook, A.M., Rutterford, C, Nunn, Andrew, McCormack, S., Crook, AM, Hayes, Richard, Richard Hayes, Hayes, R., Crook Angela M, Clare Rutterford, Rutteford, C., Angela M Crook, McCormack, Sheena, Pool, R., McCormack Sheena, Nunn Andrew, Crook, Angela M, Andrew Nunn, Rutterford Clare, Pool Robert, Robert Pool, Hayes, R   +29 more
core   +3 more sources

Formulation and evaluation of metronidazole acid gel for vaginal contraception

Journal of Pharmacy and Pharmacology, 2003
Abstract In this study, the efficacy of metronidazole as a local spermicidal agent was investigated. The drug was formulated in a concentration of 5% as an acid gel for vaginal application as a local contraception. The minimum spermicidal concentration of metronidazole was evaluated in-vitro and found to be 0.2% w/v.
Sanaa A, El-Gizawy, Nagwa I, Aglan
openaire   +2 more sources

Diffusion through Pig Gastric Mucin: Effect of Relative Humidity. [PDF]

PLoS ONE, 2016
Mucus covers the epithelium found in all intestinal tracts, where it serves as an important protecting barrier, and pharmaceutical drugs administrated by the oral, rectal, vaginal, ocular, or nasal route need to penetrate the mucus in order to reach ...
Anna Runnsjö, Aleksandra P Dabkowska, Emma Sparr, Vitaly Kocherbitov, Thomas Arnebrant, Johan Engblom   +5 more
doaj   +1 more source

Development and characterization of bioadhesive gel of microencapsulated metronidazole for vaginal use.

Iranian journal of pharmaceutical research : IJPR, 2010
The present study concerned with the development and characterization of metronidazole microcapsules prepared by thermal change method using different ratios (1:1, 1:2 and 1:4) of ethyl cellulose in order to select the best microcapsule formulation with a good encapsulation efficiency and drug release profile.
Bhabani Shankar, N, Prasant Kumar, R, Udaya Kumar, N, Benoy Bratac, B   +3 more
openaire   +2 more sources

"One teabag is better than four": Participants response to the discontinuation of 2% PRO2000/5 microbicide gel in KwaZulu-Natal, South Africa. [PDF]

, 2011
INTRODUCTION: The Microbicides Development Programme evaluated the safety and effectiveness of 0.5% and 2% PRO2000/5 microbicide gels in reducing the risk of vaginally acquired HIV.
Mhlongo Nkosinathi, Ndlovu, Hlengiwe, Hoogland Yael, Ndlovu Hlengiwe, Gafos, M, Mhlongo, N, Mzimela, Misiwe, Hoogland, Y, Misiwe Mzimela, Yael Hoogland, Gafos, Mitzy, Mutemwa Richard, Mzimela Misiwe, Nkosinathi Mhlongo, Ndlovu, H, Mutemwa, Richard, Mutemwa, R, Mhlongo, Nkosinathi, Hlengiwe Ndlovu, Mitzy Gafos, Richard Mutemwa, Gafos Mitzy, Hoogland, Yael, Mzimela, M   +23 more
core   +1 more source

An assessment of the likely acceptability of vaginal microbicides for HIV prevention among women in rural Ghana. [PDF]

, 2012
BACKGROUND: The findings of the CAPRISA tenofovir studies have raised expectations that soon an approved microbicide would be available. However it is in only a limited number of countries in sub-Saharan Africa that the acceptability of microbicides has ...
Tawiah, Charlotte, Charlotte Tawiah, Frank Baiden, Afari-Asiedu Samuel, Martha A Abdulai, Afari-Asiedu, Samuel, Abdulai, Martha A, Abdulai Martha A, Adjei Kwame, Baiden, Frank, Baiden Frank, Samuel Afari-Asiedu, Sam Newton, Adjei, George, Adjei George, Adjei, Kwame, Newton Sam, George Adjei, Tawiah Charlotte, Newton, Sam, Kwame Adjei   +20 more
core   +2 more sources

Comparison of omeprazole, metronidazole and clarithromycin with omeprazole/amoxicillin dual-therapy for the cure of Helicobacter pylori infection [PDF]

, 1998
In this randomized, multicenter trial, we evaluated the effectiveness and side effect profile of a modified omeprazole-based triple therapy to cure Helicobacter pylori infection.
Miehlke, Stephan, Bolle, Karl-Heinz, Lehn, Norbert, Höchter, Wilhelm, Klann, Hermann, Krämer, Walter, Simon, Thomas, Stolte, Manfred, Meining, Alexander, Sommer, Albrecht, Bayerdörffer, Ekkehard, Weingart, Josef   +11 more
core   +1 more source

Epidemiology of trichomoniasis in Kumasi, Ghana [PDF]

Estimates from the WHO indicate that Trichomonas vaginalis (TV) infection is the most common curable sexually transmitted infection world wide.
Adu-sarkodie, Yaw Amankwaa
core   +1 more source

Effect of Hypericum perforatum L. compared with metronidazole in bacterial vaginosis: a double-blind randomized trial

Asian Pacific Journal of Tropical Biomedicine, 2014
Objective: To compare effect of Hypericum perforatum (H. perforatum) vaginal gel with metronidazole on bacterial vaginosis (BV) in terms of initial response to treatment and preventing recurrence (primary outcomes) and also patient complaints (secondary ...
Sakineh Mohammad-Alizadeh-Charandabi, Zahra Mohammadzadeh, Azizeh Farshbaf-Khalili, Yousef Javadzadeh   +3 more
doaj   +1 more source

Nanocellulose Alleviates Intrahepatic Cholestasis of Pregnancy via Gut Microbiota‐Mediated Bile Acid Homeostasis

Advanced Science, Volume 13, Issue 45, 13 August 2026.
Nanocellulose, derived from microcrystalline cellulose (MCC) through sulfuric acid hydrolysis or mechanical grinding to produce CNC or CNF, was tested in a rat ICP model. Particularly, CNF improved gut microbiota composition, reduced secondary bile acid metabolism, and restored bile acid homeostasis through modulation of the gut–liver axis.
Muhua Yu, Hongjie Dai, Xiaocui Zhong, Qibin Li, Hui Yuan, Yang Yang, Daiyong Huang, Lei Zhang, Rui Ran, Tian He, Yuanzhi Huang, Silas Villas‐Boas, Sergey Tumanov, Richard D. Cannon, Boris Novakovic, Richard Saffery, Yuhao Zhang, Xiaojing Dong, Ting‐Li Han   +18 more
wiley   +1 more source