Results 31 to 40 of about 12,260 (143)

Activation of Mevalonate Pathway via LKB1 Is Essential for Stability of Treg Cells

Cell Reports, 2019
Summary: The function of regulatory T (Treg) cells depends on lipid oxidation. However, the molecular mechanism by which Treg cells maintain lipid metabolism after activation remains elusive.
Maheshwor Timilshina, Zhiwei You, Sonja M. Lacher, Suman Acharya, Liyuan Jiang, Youra Kang, Jung-Ae Kim, Hyeun Wook Chang, Keuk-Jun Kim, Byoungduck Park, Jae-Hyoung Song, Hyun-Jeong Ko, Yun-Yong Park, Min-Jung Ma, Mahesh Raj Nepal, Tae Cheon Jeong, Yeonseok Chung, Ari Waisman, Jae-Hoon Chang   +18 more
doaj   +1 more source

Characterization of phosphomevalonate kinase: chromosomal localization, regulation, and subcellular targeting

Journal of Lipid Research, 1999
Phosphomevalonate kinase catalyzes the conversion of mevalonate-5-phosphate to mevalonate-5-diphosphate and was originally believed to be a cytosolic enzyme. In this study we have localized the phosphomevalonate kinase gene to chromosome 1p13–1q22–23 and
Lisa M. Olivier, Ken L. Chambliss, K. Michael Gibson, Skaidrite K. Krisans   +3 more
doaj   +1 more source

Determination of mevalonate in blood plasma in man and rat. Mevalonate “tolerance” tests in man.

Journal of Lipid Research, 1979
A method is described for the determination of mevalonate in ultrafiltrates of blood plasma. The method depends on the phosphorylation of mevalonate with [gamma-32P]ATP and mevalonate kinase to 5-[32P]phosphomevalonate, and the subsequent isolation of ...
G Popják, G Boehm, T S Parker, J Edmond, P A Edwards, A M Fogelman   +5 more
doaj   +1 more source

Post-translational regulation of mevalonate kinase by intermediates of the cholesterol and nonsterol isoprene biosynthetic pathways

Journal of Lipid Research, 1997
To assess the potential for feedback inhibition by isoprene intermediates in the cholesterol and nonsterol isoprene biosynthetic pathway, we expressed human cDNAs encoding mevalonate kinase (MKase), phosphomevalonate kinase (PMKase), and mevalonate ...
D D Hinson, K L Chambliss, M J Toth, R D Tanaka, K M Gibson   +4 more
doaj   +1 more source

HMG-CoA reductase kinase: measurement of activity by methods that preclude interference by inhibitors of HMG-CoA reductase activity or by mevalonate kinase.

Journal of Lipid Research, 1982
Assay of HMG-CoA reductase kinase activity requires HMG-CoA reductase (reductase, E.C. 1.1.1.34) free of associated reductase kinase. Microsomal reductase insensitive to inactivation by Mg-nucleotides alone may be prepared by heating microsomes at 50 ...
H J Harwood, Jr, V W Rodwell
doaj   +1 more source

Weekly oral alendronate in mevalonate kinase deficiency [PDF]

Orphanet Journal of Rare Diseases, 2013
Mevalonate kinase deficiency (MKD) is caused by mutations in the MVK gene, encoding the second enzyme of mevalonate pathway, which results in subsequent shortage of downstream compounds, and starts in childhood with febrile attacks, skin, joint, and gastrointestinal symptoms, sometimes induced by vaccinations.For a history of early-onset corticosteroid-
Cantarini L., Vitale A., Magnotti F., Lucherini O. M., Caso F., Frediani B., Galeazzi M., Rigante D.   +7 more
openaire   +6 more sources

Targeting SREBP-2-Regulated Mevalonate Metabolism for Cancer Therapy

Frontiers in Oncology, 2020
Recently, targeting metabolic reprogramming has emerged as a potential therapeutic approach for fighting cancer. Sterol regulatory element binding protein-2 (SREBP-2), a basic helix-loop-helix leucine zipper transcription factor, mainly regulates genes ...
Linyuan Xue, Hongyu Qi, He Zhang, Lu Ding, Qingxia Huang, Qingxia Huang, Daqing Zhao, Boyang Jason Wu, Xiangyan Li   +8 more
doaj   +1 more source

Molecular Cloning, Characterization, and Functional Analysis of Acetyl-CoA C-Acetyltransferase and Mevalonate Kinase Genes Involved in Terpene Trilactone Biosynthesis from Ginkgo biloba

Molecules, 2017
Ginkgolides and bilobalide, collectively termed terpene trilactones (TTLs), are terpenoids that form the main active substance of Ginkgo biloba. Terpenoids in the mevalonate (MVA) biosynthetic pathway include acetyl-CoA C-acetyltransferase (AACT) and ...
Qiangwen Chen, Jiaping Yan, Xiangxiang Meng, Feng Xu, Weiwei Zhang, Yongling Liao, Jinwang Qu   +6 more
doaj   +1 more source

MicroRNA-874 targets phosphomevalonate kinase and inhibits cancer cell growth via the mevalonate pathway

Scientific Reports, 2022
The microRNA (miR) miR-874, a potential tumour suppressor, causes cell death via target gene suppression in various cancer types. Mevalonate pathway inhibition also causes cell death in breast cancer.
Alimasi Aersilan, Naoko Hashimoto, Kazuyuki Yamagata, Masataka Yokoyama, Akitoshi Nakayama, Xiaoyan Shi, Hidekazu Nagano, Ikki Sakuma, Nijiro Nohata, Takashi Kinoshita, Naohiko Seki, Bahityar Rahmutulla, Atsushi Kaneda, Siti Nurul Zhahara, Yingbo Gong, Motoi Nishimura, Shoichiro Kawauchi, Eiryo Kawakami, Tomoaki Tanaka   +18 more
doaj   +1 more source

Engineering Rhodosporidium toruloides for limonene production

Biotechnology for Biofuels, 2021
Background Limonene is a widely used monoterpene in the production of food, pharmaceuticals, biofuels, etc. The objective of this work was to engineer Rhodosporidium toruloides as a cell factory for the production of limonene.
Sasa Liu, Mengyao Zhang, Yuyao Ren, Guojie Jin, Yongsheng Tao, Liting Lyu, Zongbao K. Zhao, Xiaobing Yang   +7 more
doaj   +1 more source