Results 41 to 50 of about 13,572 (204)
, 2020 This dataset describes the effects of several mutations to human mevalonate kinase. The dataset is designed to be used with the Aquaria molecular graphics system (e.g., https://aquaria.app/Q03426/1kvk?zenodo.3632187.MVK)
Sean O'Donoghue, Mike Rogers
core +1 more source
Determination of mevalonate in blood plasma in man and rat. Mevalonate “tolerance” tests in man.
Journal of Lipid Research, 1979 A method is described for the determination of mevalonate in ultrafiltrates of blood plasma. The method depends on the phosphorylation of mevalonate with [gamma-32P]ATP and mevalonate kinase to 5-[32P]phosphomevalonate, and the subsequent isolation of ...
G Popják +5 more
doaj +1 more source
Journal of Lipid Research, 1982 Assay of HMG-CoA reductase kinase activity requires HMG-CoA reductase (reductase, E.C. 1.1.1.34) free of associated reductase kinase. Microsomal reductase insensitive to inactivation by Mg-nucleotides alone may be prepared by heating microsomes at 50 ...
H J Harwood, Jr, V W Rodwell
doaj +1 more source
Journal of Lipid Research, 1997 To assess the potential for feedback inhibition by isoprene intermediates in the cholesterol and nonsterol isoprene biosynthetic pathway, we expressed human cDNAs encoding mevalonate kinase (MKase), phosphomevalonate kinase (PMKase), and mevalonate ...
D D Hinson +4 more
doaj +1 more source
Identification and characterization of human mevalonate kinase inhibitors
, 2023 The mevalonate pathway is responsible for the synthesis of isoprenoids, which are essential for various biological activities, such as cell signaling and membrane function. Mevalonate kinase (MK) is a critical enzyme in this pathway, converting mevalonic
Salari, Saman
core +1 more source
Elektroenzymatische CO2‐Fixierung
Angewandte Chemie, EarlyView.Die elektroenzymatische CO2‐Fixierung ermöglicht eine energieeffiziente, hochselektive Synthese komplexer Moleküle. Um ihr volles Potenzial auszuschöpfen, ist ein grundlegendes Verständnis von elektrodengekoppelten Reduktasen und Carboxylasen erforderlich.
Leonardo Castañeda‐Losada +4 more
wiley +1 more source
Angewandte Chemie International Edition, EarlyView.Electroenzymatic CO2 fixation enables energy‐efficient, highly selective synthesis of complex molecules. Unlocking its full potential requires fundamental understanding of electrode‐coupled reductases and carboxylases. This review critically discusses available enzymes, product scope, and key thermodynamic and kinetic considerations, highlighting ...
Leonardo Castañeda‐Losada +4 more
wiley +1 more source
p53 regulates Mevalonate Metabolic pathway
, 2014 2012-2013The mevalonate pathway is an important metabolic pathway implicated in multiple aspects of tumorigenesis. In this study, I provided evidences about genetic and pharmacologic perturbation of p53, which directly influenced expression of mevalonate
D'Alessandro, Alba
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Catalytic mechanism of mevalonate kinase revisited, a QM/MM study [PDF]
, 2019 Mevalonate Kinase (MVK) catalyses the ATP-Mg2+ mediated phosphate transfer of mevalonate to produce mevalonate 5-phosphate and is a key kinase in the mevalonate pathway in the biosynthesis of isopentenyl diphosphate, the precursor of isoprenoid-based ...
McClory, James +6 more
core +1 more source
Biocatalytic asymmetric phosphorylation of mevalonate
, 2014 The excellent selectivity of the mevalonate kinase-catalyzed phosphorylation of mevalonate simplifies lengthy multi-step routes to (R)-mevalonate-5-phosphate to a one-step biocatalytic reaction, because the phosphate group can be transferred directly and
Hellriegel, C. +5 more
core +2 more sources