Results 31 to 40 of about 13,572 (204)

Structure, substrate recognition and reactivity of Leishmania major mevalonate kinase [PDF]

, 2007
This research was supported by the German Academic Exchange Service (DAAD), the Wellcome Trust (TKS and WNH as Trust Senior Research fellows), the Biotechnology and Biological Science Research Council (Structural Proteomics of Rational Targets) and the ...
Tanja Sgraja, Smith, Terry K, Terry K Smith, Sgraja, Tanja, Hunter, William N., William N Hunter, Hunter, William N   +6 more
core   +1 more source

3-Hydroxy-3-methylglutaryl CoA reductase and mevalonate kinase of Neurospora crassa

Journal of Lipid Research, 1974
Two enzymes of polyisoprenoid synthesis, 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase (mevalonate:NADP oxidoreductase [acylating CoA] , EC 1.1.1.34) and mevalonate kinase (ATP:mevalonate 5-phosphotransferase, EC 2.7.1.36), are present in the
Richard L. Imblum, Victor W. Rodwell
doaj   +1 more source

Enterococcus faecalis mevalonate kinase [PDF]

Protein Science, 2004
AbstractGram‐positive pathogens synthesize isopentenyl diphosphate, the five‐carbon precursor of isoprenoids, via the mevalonate pathway. The enzymes of this pathway are essential for the survival of these organisms, and thus may represent possible targets for drug design.
Matija, Hedl, Victor W, Rodwell
openaire   +2 more sources

Mevalonate kinase variants

, 2021
This dataset describes the effects of several mutations to human mevalonate kinase. The dataset is designed to be used with the Aquaria molecular graphics system (e.g., https://aquaria.app/Mouse/MVK?zenodo.3632187.V377I or https://aquaria.app/Mouse/MVK ...
Sean O'Donoghue, Mike Rogers
core   +1 more source

Mechanisms underlying inflammation in mevalonate kinase deficiency [PDF]

Mevalonate kinase deficiency is an autoinflammatory metabolic disorder caused by biallelic pathogenic variants in the MVK gene characterized by lifelong recurring and often unprovoked episodes of inflammation.
Politiek, F.A.
core   +3 more sources

Further engineering of R. toruloides for the production of terpenes from lignocellulosic biomass

Biotechnology for Biofuels, 2021
Background Mitigation of climate change requires that new routes for the production of fuels and chemicals be as oil-independent as possible. The microbial conversion of lignocellulosic feedstocks into terpene-based biofuels and bioproducts represents ...
James Kirby, Gina M. Geiselman, Junko Yaegashi, Joonhoon Kim, Xun Zhuang, Mary Bao Tran-Gyamfi, Jan-Philip Prahl, Eric R. Sundstrom, Yuqian Gao, Nathalie Munoz, Kristin E. Burnum-Johnson, Veronica T. Benites, Edward E. K. Baidoo, Anna Fuhrmann, Katharina Seibel, Bobbie-Jo M. Webb-Robertson, Jeremy Zucker, Carrie D. Nicora, Deepti Tanjore, Jon K. Magnuson, Jeffrey M. Skerker, John M. Gladden   +21 more
doaj   +1 more source

Activation of Mevalonate Pathway via LKB1 Is Essential for Stability of Treg Cells

Cell Reports, 2019
Summary: The function of regulatory T (Treg) cells depends on lipid oxidation. However, the molecular mechanism by which Treg cells maintain lipid metabolism after activation remains elusive.
Maheshwor Timilshina, Zhiwei You, Sonja M. Lacher, Suman Acharya, Liyuan Jiang, Youra Kang, Jung-Ae Kim, Hyeun Wook Chang, Keuk-Jun Kim, Byoungduck Park, Jae-Hyoung Song, Hyun-Jeong Ko, Yun-Yong Park, Min-Jung Ma, Mahesh Raj Nepal, Tae Cheon Jeong, Yeonseok Chung, Ari Waisman, Jae-Hoon Chang   +18 more
doaj   +1 more source

Mevalonate kinase deficiency

Neurology, 2004
Both mevalonic aciduria, characterized by psychomotor retardation, cerebellar ataxia, recurrent fever attacks, and death in early childhood, and hyper-immunoglobulin D (hyper-IgD) syndrome, with recurrent fever attacks without neurologic symptoms, are caused by a functional deficiency of mevalonate kinase.
Simon, A., Kremer, H.P.H., Wevers, R.A., Scheffer, H., Jong, J.G.N. de, Meer, J.W.M. van der, Drenth, J.P.H.   +6 more
openaire   +5 more sources

Mevalonate kinase is a cytosolic enzyme in humans [PDF]

Journal of Cell Science, 2004
In the past decade several reports have appeared which suggest that peroxisomes play a central role in isoprenoid/cholesterol biosynthesis. These suggestions were based primarily on the reported finding of several of the enzymes of the presqualene segment of the biosynthetic pathway in peroxisomes.
Hogenboom, Sietske, Tuyp, John J. M., Espeel, Marc, Koster, Janet, Wanders, Ronald J. A., Waterham, Hans R.   +5 more
openaire   +2 more sources

Characterization of phosphomevalonate kinase: chromosomal localization, regulation, and subcellular targeting

Journal of Lipid Research, 1999
Phosphomevalonate kinase catalyzes the conversion of mevalonate-5-phosphate to mevalonate-5-diphosphate and was originally believed to be a cytosolic enzyme. In this study we have localized the phosphomevalonate kinase gene to chromosome 1p13–1q22–23 and
Lisa M. Olivier, Ken L. Chambliss, K. Michael Gibson, Skaidrite K. Krisans   +3 more
doaj   +1 more source