Results 91 to 100 of about 38,617 (240)

Long‐term disease control of disseminated superficial actinic porokeratosis (DSAP) with simvastatin 2%/ cholesterol 2% cream

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Introduction Disseminated superficial actinic porokeratosis (DSAP) is a rare keratinization disorder associated with an increased risk of cutaneous tumors. Objectives To develop a feasible and easy‐to‐apply treatment regimen for long‐time disease control of DSAP including prevention of new skin tumors. Patients and Methods 19 patients with DSAP
Berenice M. Lang, Gregor Ojak, Mandy Crummenauer, Joanna Wegner, Caroline Mann, Stephan Grabbe, Petra Staubach   +6 more
wiley   +1 more source

Isolation of isoprene degrading bacteria from soils, development of isoA gene probes and identification of the active isoprene degrading soil community using DNA-stable isotope probing [PDF]

, 2016
Emissions of biogenic volatile organic compounds (bVOCs), are an important element in the global carbon cycle, accounting for a significant proportion of fixed carbon.
Acuña Alvarez, Altschul, Atkinson, Bertoni, Broadgate, Bäck, Capone, Cardy, Cleveland, Cleveland, Cole, Crombie, Dowd, Dumont, Edgar, Ensign, Ewers, Exton, Fiore, Gelmont, Ginkel, Ginkel, Gray, Greenberg, Guenther, Hylckama Vlieg, Hylckama Vlieg, Hylckama Vlieg, Julsing, Kirschke, Kottegoda, Kuzma, Lane, Leahy, Logan, Loivamäki, Loreto, Marmur, McLeod, Muyzer, Neufeld, Pacifico, Pegoraro, Radajewski, Schaefer, Sharkey, Sharkey, Srivastva, Tamura, Tuovinen, Vickers, Wiedinmyer, Wiedinmyer, Zhou   +53 more
core   +1 more source

Interaction Between Mevalonate Pathway and Retinoic Acid‐Induced Differentiation [PDF]

BioMed Research International, 2001
All trans retinoic acid (ATRA) is a potent inducer of differentiation of HL‐60 cell line. The pretreatment of the cells by compactin, a competitive inhibitor of 3‐hydroxy‐3‐methylglutaryl (HMG) CoA reductase, during 24 hours, enhances the ATRA‐induced cell differentiation.
Gueddari-Pouzols, Naima, Duriez, Patrick, Chomienne, Christine, Trussardi, Aurélie, Jardillier, Jean Claude   +4 more
openaire   +2 more sources

Deciphering the properties and reaction mechanism of anhydromevalonate phosphate decarboxylase, a prenylated flavin mononucleotide‐dependent enzyme in the archaeal mevalonate pathway

The FEBS Journal, EarlyView.
Characterization of anhydromevalonate phosphate decarboxylase, the UbiD‐family decarboxylase involved in the archaeal mevalonate pathway, was conducted. The enzyme is responsible for the biosynthesis of isoprenoids, such as archaeal membrane lipids, respiratory quinones, and dolichols.
Rino Ishikawa, Natsumi Matsushima, Soma Ishimine, Honoka Nakamoto, Hajime Hayakawa, Yoko Yasuno, Tetsuro Shinada, Hiroshi Kawaide, Tomokazu Ito, Hisashi Hemmi   +9 more
wiley   +1 more source

Metabolomics Analysis of the Toxic Effects of the Production of Lycopene and Its Precursors

Frontiers in Microbiology, 2018
Using cells as microbial factories enables highly specific production of chemicals with many advantages over chemical syntheses. A number of exciting new applications of this approach are in the area of precision metabolic engineering, which focuses on ...
April M. Miguez, Monica P. McNerney, Mark P. Styczynski   +2 more
doaj   +1 more source

The TriForC database : a comprehensive up-to-date resource of plant triterpene biosynthesis [PDF]

, 2018
Triterpenes constitute a large and important class of plant natural products with diverse structures and functions. Their biological roles range from membrane structural components over plant hormones to specialized plant defence compounds.
Bak, Soren, Botzki, Alexander, Coppens, Frederik, De Bo, Christof, Goossens, Alain, Iñigo, Sabrina, Kreft, Lukasz, Miettinen, Karel, Pollier, Jacob   +8 more
core   +2 more sources

(R)-Mevalonate 3-Phosphate Is an Intermediate of the Mevalonate Pathway in Thermoplasma acidophilum [PDF]

Journal of Biological Chemistry, 2014
The lack of a few conserved enzymes in the classical mevalonate pathway and the widespread existence of isopentenyl phosphate kinase suggest the presence of a partly modified mevalonate pathway in most archaea and in some bacteria. In the pathway, (R)-mevalonate 5-phosphate is thought to be metabolized to isopentenyl diphosphate via isopentenyl ...
Yasuhiro, Azami, Ai, Hattori, Hiroto, Nishimura, Hiroshi, Kawaide, Tohru, Yoshimura, Hisashi, Hemmi   +5 more
openaire   +2 more sources

Steroidogenic compensation and lipid deficiency with enhanced NAD+ salvage in small‐for‐gestational‐age placenta

The FEBS Journal, EarlyView.
Fetal growth restriction is associated with placental metabolic adaptations. In small‐for‐gestational‐age placenta (SGA), cholesterol receptors and steroidogenic enzymes are upregulated, enhancing steroidogenesis. NAD salvage pathway is also increased to support NADP+/NADPH requirements.
Serena Xodo, Lorenza Driul, Vanessa Tolotto, Eros Di Giorgio, Luigi E. Xodo   +4 more
wiley   +1 more source

The mevalonate precursor enzyme HMGCS1 is a novel marker and key mediator of cancer stem cell enrichment in luminal and basal models of breast cancer.

PLoS ONE, 2020
The definitive characterization of common cancer stem cell (CSCs) subpopulations in breast cancer subtypes with distinct genotypic and phenotypic features remains an ongoing challenge.
Claire A Walsh, Nina Akrap, Elena Garre, Ylva Magnusson, Hannah Harrison, Daniel Andersson, Emma Jonasson, Svanheidur Rafnsdottir, Hani Choudhry, Francesca Buffa, Jiannis Ragoussis, Anders Ståhlberg, Adrian Harris, Göran Landberg   +13 more
doaj   +1 more source

Enzymes of the mevalonate pathway of isoprenoid biosynthesis [PDF]

Archives of Biochemistry and Biophysics, 2011
The mevalonate pathway accounts for conversion of acetyl-CoA to isopentenyl 5-diphosphate, the versatile precursor of polyisoprenoid metabolites and natural products. The pathway functions in most eukaryotes, archaea, and some eubacteria. Only recently has much of the functional and structural basis for this metabolism been reported.
openaire   +2 more sources