Results 111 to 120 of about 38,617 (240)

Cholesterol and Mevalonate: Two Metabolites Involved in Breast Cancer Progression and Drug Resistance through the ERRα Pathway

Cells, 2020
Breast cancer is the second greatest cause of cancer-related death in women. Resistance to endocrine treatments or chemotherapy is a limiting drawback.
Matteo Brindisi, Marco Fiorillo, Luca Frattaruolo, Federica Sotgia, Michael P. Lisanti, Anna Rita Cappello   +5 more
doaj   +1 more source

Metabolism of low-density lipoproteins by cultured hepatocytes from normal and homozygous familial hypercholesterolemic subjects [PDF]

, 1986
The profoundly elevated concentrations of low-density lipoproteins (LDL) present in homozygous familial hypercholesterolemia lead to symptomatic cardiovascular disease and death by early adulthood.
Brewer, HB, Demosky, SJ, Edge, SB, Gregg, RE, Hoeg, JM, Starzl, TE, Triche, T   +6 more
core   +1 more source

Cross‐Species Reprogramming of Developmental Plasticity and Metabolic Rewiring via Banana‐Derived WUS2 Developmental Regulator

Plant Biotechnology Journal, EarlyView.
ABSTRACT Plant regeneration is governed by intrinsic gene regulation and phytohormonal cues. WUSCHEL (WUS) gene promotes regeneration, but its broader functional role remains unexplored. Here, we demonstrate that the constitutive and inducible expression of banana‐derived WUS2 (GN‐WUS2) enhances regeneration in Nicotiana tabacum (tobacco) and Musa ...
Roni Chaudhary, Surender Singh, Usman Ali, Siddharth Tiwari   +3 more
wiley   +1 more source

RORγ is a targetable master regulator of cholesterol biosynthesis in a cancer subtype. [PDF]

, 2019
Tumor subtype-specific metabolic reprogrammers could serve as targets of therapeutic intervention. Here we show that triple-negative breast cancer (TNBC) exhibits a hyper-activated cholesterol-biosynthesis program that is strongly linked to nuclear ...
Bold, Richard J, Borowsky, Alexander D, Cai, Demin, Chen, Hong-Wu, Chen, Xinbin, Evans, Ronald M, Fiehn, Oliver, Gao, Bei, Huang, Zenghong, Jiang, Yuqian, Kung, Hsing-Jien, Lam, Kit S, Lara, Primo N, Li, Jian Jian, Li, Jin, To, Ka-Fai, Wang, Junjian, Wu, Feng, Xu, Jianzhen, Zhao, Ruqian, Zou, Hongye, Zou, June X   +21 more
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Analysis of BpbHLH Gene Family Responsive to MeJA Signalling in Betula platyphylla Suk. and Functional Mechanisms of BpbHLH42/44 in Genetic Improvement and Triterpenoid Biosynthesis

Plant Biotechnology Journal, EarlyView.
ABSTRACT The basic helix–loop–helix (bHLH) transcription factor family regulates plant secondary metabolism, development and stress responses. Although triterpenoids such as betulinic acid (BA), betulin (BT) and oleanolic acid (OA) from Betula platyphylla Suk.
Ying Li, Linlin Xu, Jiale Cui, Siyao Wang, Yige Yuan, Changyixin Xiao, Xiaozhou Luo, Dmitry Baleev, Yaguang Zhan, Jing Yin   +9 more
wiley   +1 more source

Physiological modeling of isoprene dynamics in exhaled breath [PDF]

, 2003
Human breath contains a myriad of endogenous volatile organic compounds (VOCs) which are reflective of ongoing metabolic or physiological processes.
King, Julian, Koc, Helin, Unterkofler, Karl, Mochalski, Pawel, Kupferthaler, Alexander, Teschl, Gerald, Teschl, Susanne, Hinterhuber, Hartmann, Amann, Anton   +8 more
core   +4 more sources

Root Structural and Metabolic Plasticity Confers Tolerance to Salinity in Wild Barley Species Grown Under Waterlogging

Plant, Cell &Environment, EarlyView.
ABSTRACT Salinity combined with waterlogging is a major abiotic stress that severely limits crop growth and yield. We investigated species‐specific adaptations to salinity under constant waterlogging conditions in the wild halophytic barleys Hordeum marinum and H. glaucum, compared with the cultivated H. vulgare.
Stanislav Isayenkov, Ljudmilla Borisjuk, Simon Meyer, Alexander Hilo, Dominic Knoch, Tobias Meitzel, Bettina Hause, Yudelsy Antonia Tandron Moya, Hardy Rolletschek, Edgar Peiter, Volodymyr Radchuk   +10 more
wiley   +1 more source

Production of Mevalonate from Glycerol by Escherichia coli Citrate Synthase Variants

Fermentation
Mevalonate is a biochemical precursor to a wide range of isoprenoids. Because the mevalonate pathway uses three moles of acetyl–CoA, native pathways which metabolize acetyl–CoA, including citrate synthase, strongly compete with mevalonate synthesis.
Caroline E. Hartner, Mark A. Eiteman
doaj   +1 more source

Isoprenoids responsible for protein prenylation modulate the biological effects of statins on pancreatic cancer cells

Lipids in Health and Disease, 2017
Background Statin treatment of hypercholesterolemia is accompanied also with depletion of the mevalonate intermediates, including farnesyl pyrophosphate (FPP) and geranylgeranyl pyrophosphate (GGPP) necessary for proper function of small GTPases.
Helena Gbelcová, Silvie Rimpelová, Zdeněk Knejzlík, Jana Šáchová, Michal Kolář, Hynek Strnad, Vanda Repiská, Walter Cosimo D’Acunto, Tomáš Ruml, Libor Vítek   +9 more
doaj   +1 more source

The role of statin drugs in combating cardiovascular diseases –A review [PDF]

, 2011
Statins clearly confer substantial benefit in people with established cardiovascular (CV) disease. Increased cholesterol levels have been associated with cardiovascular diseases (CVD), and statins are therefore used in the prevention of these diseases ...
Suresh Pichandi , Palanisamy Pasupathi, Y.Yagneswara Rao, Jawahar Farook, Athimoolam Ambika, Babu Shankar Ponnusha , Sathiyamoorthy Subramaniyam, Rajaram Virumandy, Boopathi subramaniyam Int J Cur Sci Res.
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