Results 171 to 180 of about 10,880 (220)

Human γδ T Cell Function Is Impaired Upon Mevalonate Pathway Inhibition. [PDF]

open access: yesImmunology
Suen TK   +14 more
europepmc   +1 more source

IL-33-mediated mast cell and eosinophil function requires isoprenylation. [PDF]

open access: yesFront Immunol
Burchett JR   +11 more
europepmc   +1 more source

Occurrence of Mevalonic Acid in Carrots

Nature, 1961
ALTHOUGH tracer studies in a number of carotenogenic systems1,2 have conclusively proved that mevalonic acid is an effective precursor of carotenes, the presence of mevalonic acid has not been demonstrated in any of such systems. In this laboratory an attempt has been made to isolate mevalonic acid from carrots.
V V, MODI, D K, PATWA
openaire   +4 more sources

Stereospecificity of Enzymic Reactions involving Mevalonic Acid

Nature, 1960
MOST of the biosynthetic studies with mevalonic acid have so far been carried out with the racemic substance labelled with carbon-14. There have been no reports indicating a utilization greater than 50 per cent of DL-mevalonate either in vivo or in vitro in any enzymic reaction.
R H, CORNFORTH   +3 more
openaire   +4 more sources

Determination of mevalonic acid in human urine as mevalonic acid lactone by gas chromatography–mass spectrometry

Journal of Chromatography B: Biomedical Sciences and Applications, 2001
Mevalonic acid in urine is converted to its lactone form by incubation overnight at acidic pH, extracted and analysed by GC-MS. The lower limit of quantitation of 7.5 ng/ml provides adequate sensitivity to measure changes in urinary excretion of MVA following administration of drugs which affect cholesterol synthesis.
B H, Woollen   +3 more
openaire   +4 more sources

Terpene Formation in Pine from Mevalonic Acid

Nature, 1958
RECENT studies have demonstrated that mevalonic acid is a key intermediate in the biosynthesis of animal sterols1. Studies of the origin of triterpenes and carotenoids in soya bean and fungi indicate that these compounds may also be formed from acetate through mevalonic acid2.
openaire   +3 more sources

Mevalonates Restore Zoledronic Acid–induced Osteoclastogenesis Inhibition

Journal of Dental Research, 2014
Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is likely to be caused by continuous imperfection of bone healing after surgical treatments in patients with long-term administration of nitrogen-containing bisphosphonates (NBPs). NBPs inhibit osteoclastic bone resorption by impairing the mevalonic acid sterol pathway in osteoclasts.
Y, Nagaoka   +4 more
openaire   +2 more sources

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