Results 171 to 180 of about 6,314 (218)

Determination of mevalonic acid in human urine as mevalonic acid lactone by gas chromatography–mass spectrometry

Biomedical Applications, 2001
Mevalonic acid in urine is converted to its lactone form by incubation overnight at acidic pH, extracted and analysed by GC-MS. The lower limit of quantitation of 7.5 ng/ml provides adequate sensitivity to measure changes in urinary excretion of MVA following administration of drugs which affect cholesterol synthesis.
B H, Woollen, P C, Holme, W J, Northway, P D, Martin   +3 more
exaly   +3 more sources

Occurrence of Mevalonic Acid in Carrots

Nature, 1961
ALTHOUGH tracer studies in a number of carotenogenic systems1,2 have conclusively proved that mevalonic acid is an effective precursor of carotenes, the presence of mevalonic acid has not been demonstrated in any of such systems. In this laboratory an attempt has been made to isolate mevalonic acid from carrots.
V V Modi
exaly   +3 more sources

In Vitro Metabolism of Mevalonic Acid in the Bovine Retina

Journal of Neurochemistry, 1986
Abstract: Bovine retinas were incubated with 3RS‐[5‐3H]‐ mevalonic acid under conditions similar to those previously shown to support opsin biosynthesis in vitro. TLC of the total lipids indicated the formation of numerous radiolabeled components, including sterols, hydrocarbons, and “fatty acid‐like material.” The nonsaponifiable lipids were analyzed
Steven J Fliesler, George J Schroepfer
exaly   +3 more sources

MEVALONIC ACID MEVALONIC LACTONE

, 1976
Darshan Ranganathan, Subramania Ranganathan   +1 more
openaire   +2 more sources

Topical Mevalonic Acid Stimulates De Novo Cholesterol Synthesis and Epidermal Permeability Barrier Homeostasis in Aged Mice11The authors did not submit a completed declaration of conflict of interest form as requested by the JID’s ‘‘Information for authors’’.

Journal of Investigative Dermatology, 2000
Extracellular lipids of the stratum corneum, which are composed of cholesterol, fatty acid, and ceramides, are essential for the epidermal permeability barrier function. With damage to the barrier, a decreased capacity for epidermal lipid biosynthesis in
Norito Katoh, Shinya Hirano, Hirokazu Yasuno   +2 more
exaly   +2 more sources

The metabolism of acetate and mevalonic acid by lactobacilli I. The effect of acetate and mevalonic acid on growth

Biochimica et Biophysica Acta, 1962
Abstract The requirement of three species of lactobacillus for acetate and its replacement by mevalonic acid was investigated. It was found that, in the presence of 1% glucose, Lactobacillus acidophilus had a requirement for sodium acetate which could be replaced by 1/8000 times its concentration of mevalonic acid, but when the glucose ...
K J, THORNE, E, KODICEK
openaire   +2 more sources

Is mevalonic acid a precursor of the corticosteroids?

Archives of Biochemistry and Biophysics, 1962
Abstract Bovine adrenal tissue preparations (whole homogenates or a combination of microsomal and supernatant fractions) readily convert acetate-1-C 14 to corticosteroids, 14 of which have been isolated and identified. In parallel experiments with aliquots of the same adrenal tissue preparations, mevalonate-2-C 14 was not found to be incorporated ...
M J, BRYSON, M L, SWEAT
openaire   +2 more sources

Mevalonic Acid Analogs as Inhibitors of Cholesterol Biosynthesis

Journal of Pharmaceutical Sciences, 1981
A series of 20 mevalonic acid analogs was synthesized and tested for their ability to inhibit cholesterol biosynthesis from [2-14C]-mevalonate in rat liver homogenates. Removal of the 5-hydroxyl group from mevalonic acid produced an active inhibitor, 3-hydroxy-3-methylpentanoic acid. Removal of the 3-hydroxyl group, addition of an aromatic group in the
C R, DeBold, J C, Elwood
openaire   +2 more sources

Metabolism of mevalonic acid to phosphorylated derivatives in Chlorella

Biochemical and Biophysical Research Communications, 1977
Summary The incorporation of mevalonic acid into phosphorylated derivatives was studied for the first time in Chlorophyceae algae. Cell-free extracts and cell suspensions of Chlorella fusca were able to phosphorylate mevalonic acid. The total mevalonate phosphorylation showed a clear maximum at pH 8.2.
A, Linares, M D, Suarez, E, Garcia-Peregrin   +2 more
openaire   +2 more sources

Stereospecificity of Enzymic Reactions involving Mevalonic Acid

Nature, 1960
MOST of the biosynthetic studies with mevalonic acid have so far been carried out with the racemic substance labelled with carbon-14. There have been no reports indicating a utilization greater than 50 per cent of DL-mevalonate either in vivo or in vitro in any enzymic reaction.
R H, CORNFORTH, K, FLETCHER, H, HELLIG, G, POPJAK   +3 more
openaire   +2 more sources