Results 81 to 90 of about 7,531 (200)

Vaccines with the MF59 Adjuvant Do Not Stimulate Antibody Responses against Squalene [PDF]

Clinical and Vaccine Immunology, 2006
ABSTRACT Squalene is a naturally occurring oil which has been used in the development of vaccine adjuvants, such as the oil-in-water emulsion MF59. In past years, by use of noncontrolled and nonvalidated assays, a claim was made that antisqualene antibodies were detectable in the sera of individuals with the so-called Gulf War syndrome. Using
Giuseppe, Del Giudice, Elena, Fragapane, Roberto, Bugarini, Maninder, Hora, Thomas, Henriksson, Emanuela, Palla, Derek, O'hagan, John, Donnelly, Rino, Rappuoli, Audino, Podda   +9 more
openaire   +2 more sources

Principales sistemas de entrega de antígenos en Medicina Veterinaria y Humana [PDF]

, 2014
Las vacunas modernas se basan generalmente en proteínas recombinantes altamente purificadas. Esta alta pureza representa uno de los mayores avances en términos de seguridad, en comparación a las estrategias de vacunación tradicionales basadas en ...
Siel, Daniela, Sáenz, Leonardo, Vidal, Sonia   +2 more
core   +2 more sources

The Next Disease X‐ H5N6 Avian Influenza's Evolving Threat to Human Health and Chances of Future Global Outbreak: A Narrative Review

Health Science Reports, Volume 8, Issue 11, November 2025.
ABSTRACT Background and Aims H5N6 avian influenza has been a concern that can initiate the next global pandemic (called Disease X). Most infections have been among those in Asia, especially China, since the 2014 first human case. With a fatality rate of 61%, the virus is very deadly, even though the total number of human cases is relatively low.
Shoubeho Sadique Shandhi, Mosiur Rahman, Mohammad Shahriar, Ramisa Anjum   +3 more
wiley   +1 more source

A caprine herpesvirus 1 vaccine adjuvanted with MF59™ protects against vaginal infection and interferes with the establishment of latency in goats.

PLoS ONE, 2012
The immunogenicity and the efficacy of a beta-propiolactone-inactivated caprine herpesvirus 1 (CpHV-1) vaccine adjuvanted with MF59™ were tested in goats.
Mariarosaria Marinaro, Giovanni Rezza, Giuseppe Del Giudice, Valeriana Colao, Elvira Tarsitano, Michele Camero, Michele Losurdo, Canio Buonavoglia, Maria Tempesta   +8 more
doaj   +1 more source

Preclinical development of a molecular clamp‐stabilised subunit vaccine for severe acute respiratory syndrome coronavirus 2

Clinical & Translational Immunology, 2021
Objectives Efforts to develop and deploy effective vaccines against severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) continue at pace. Here, we describe rational antigen design through to manufacturability and vaccine efficacy of a prefusion ...
Daniel Watterson, Danushka K Wijesundara, Naphak Modhiran, Francesca L Mordant, Zheyi Li, Michael S Avumegah, Christopher LD McMillan, Julia Lackenby, Kate Guilfoyle, Geert vanAmerongen, Koert Stittelaar, Stacey TM Cheung, Summa Bibby, Mallory Daleris, Kym Hoger, Marianne Gillard, Eve Radunz, Martina L Jones, Karen Hughes, Ben Hughes, Justin Goh, David Edwards, Judith Scoble, Lesley Pearce, Lukasz Kowalczyk, Tram Phan, Mylinh La, Louis Lu, Tam Pham, Qi Zhou, David A Brockman, Sherry J Morgan, Cora Lau, Mai H Tran, Peter Tapley, Fernando Villalón‐Letelier, James Barnes, Andrew Young, Noushin Jaberolansar, Connor AP Scott, Ariel Isaacs, Alberto A Amarilla, Alexander A Khromykh, Judith MA van denBrand, Patrick C Reading, Charani Ranasinghe, Kanta Subbarao, Trent P Munro, Paul R Young, Keith J Chappell   +49 more
doaj   +1 more source

Flagellins as Vaccine Adjuvants and Cancer Immunotherapy: Recent Advances and Future Prospects

Immunology, Volume 176, Issue 3, Page 277-303, November 2025.
The figure depicts the role of flagellin in immune cells. Flagellin interacts with TLR5, resulting in the formation of homodimers and the recruitment of MyD88, which activates the IκB and MAPK signalling pathways. This results in the activation of NF‐κB and AP‐1, producing TNF‐α, IL‐6, IL‐8, and IL‐12.
Asma Talukder, Md. Mijanur Rahman, Md. Sifat Rahi, Dean L. Pountney, Ming Q. Wei   +4 more
wiley   +1 more source

Distant metastases of melanoma exhibit varying extent of intrapatient proteogenomic heterogeneity

Clinical and Translational Medicine, Volume 15, Issue 10, October 2025.
Comprehensive proteogenomic profiling of post mortem melanoma metastases from patients with multiple lesions reveals the protein‐level mutation landscape and dominant phenotypes of distant metastases. The study uncovers varying levels of intrapatient heterogeneity, potentially associated with survival and therapeutic response.
Beata Szeitz, Yanick Paco Hagemeijer, Zoltan Gabor Pahi, Zsuzsanna Ujfaludi, Magdalena Kuras, Jimmy Rodriguez, Viktoria Doma, Reka Mohacsi, Magdolna Herold, Zoltan Herold, Zsolt Horvath, Indira Pla, Yutaka Sugihara, Bo Baldetorp, Henrik Lindberg, Henriett Oskolas, Melinda Rezeli, Jeovanis Gil, Roger Appelqvist, Lajos V. Kemeny, Jessica Guedes, Johan Malm, Aniel Sanchez, Imre Miklos Boros, Istvan Balazs Nemeth, Victor Guryev, Tibor Pankotai, Krzysztof Pawłowski, Elisabet Wieslander, Attila Marcell Szasz, David Fenyö, Peter Horvatovich, Jozsef Timar, György Marko‐Varga, Lazaro Hiram Betancourt   +34 more
wiley   +1 more source

Effectiveness of A(H1N1)pdm09 influenza vaccine in adults recommended for annual influenza vaccination. [PDF]

PLoS ONE, 2013
INTRODUCTION: Because of variability in published A(H1N1)pdm09 influenza vaccine effectiveness estimates, we conducted a study in the adults belonging to the risk groups to assess the A(H1N1)pdm09 MF59-adjuvanted influenza vaccine effectiveness. METHODS:
Giedre Gefenaite, Margot Tacken, Jens Bos, Irina Stirbu-Wagner, Joke C Korevaar, Ronald P Stolk, Bert Wolters, Marc Bijl, Maarten J Postma, Jan Wilschut, Kristin L Nichol, Eelko Hak   +11 more
doaj   +1 more source

Impact of Th1 CD4 Follicular Helper T Cell Skewing on Antibody Responses to an HIV-1 Vaccine in Rhesus Macaques. [PDF]

, 2020
Generating durable humoral immunity through vaccination depends upon effective interactions of follicular helper T (Tfh) cells with germinal center (GC) B cells.
Amara, Rama R, Beck, Zoltan, Dinasarapu, Ashok R, Elizaldi, Sonny R, Foehl, David H, Forthal, Donald N, Gach, Johannes S, Iyer, Smita S, Kozlowski, Pamela A, LaBranche, Celia C, Lakshmanappa, Yashavanth Shaan, Matyas, Gary R, Nguyen, Nancy K, Rane, Niharika N, Rao, Mangala, Reimann, Keith A, Schmidt, Brian A, Shen, Xiaoying, Tomaras, Georgia D, Trinh, Hung V, Verma, Anil, Walter, Korey A   +21 more
core  

Design Strategies for Novel Lipid Nanoparticle for mRNA Vaccine and Therapeutics: Current Understandings and Future Perspectives

MedComm, Volume 6, Issue 10, October 2025.
This review summarizes strategies to optimize lipid nanoparticles (LNPs) for improved targeting, endosomal escape, and safety. It highlights mRNA design, alternative delivery systems, and recent therapeutic advances across infectious diseases, cancer, and drug applications.
Xiaochi Li, Junli Li, Jiazheng Wei, Weixin Du, Cheng Su, Xiaobin Shen, Aihua Zhao, Miao Xu   +7 more
wiley   +1 more source