Results 1 to 10 of about 3,745 (115)

AS01B-, MF59-, and alum-based adjuvants and HIV vaccine immunogenicity: a post-hoc cross-protocol comparison of results from HVTN 100, 107, 120, and 702 [PDF]

Frontiers in Immunology
IntroductionVaccine adjuvants are crucial in HIV vaccine development, enhancing immune responses. Immune responses generated by different adjuvanted vaccines are rarely compared directly with the same vaccine antigens.MethodsThis retrospective cross ...
Ferdinando Menezes, Shiyu Chen, Nicole Grunenberg, Mookho Malahleha, Kathy Mngadi, Monde Muyoyeta, Fatima Laher, Zvavahera Mike Chirenje, Zvavahera Mike Chirenje, Linda-Gail Bekker, Paul Goepfert, Glenda E. Gray, Glenda E. Gray, Glenda E. Gray, Georgia Tomaras, Georgia Tomaras, M Juliana McElrath, M Juliana McElrath, Esper Kallas, Alison C. Roxby, Zoe Moodie   +20 more
doaj   +2 more sources

Enhanced immunogenicity of Staphylococcus aureus IsdE vaccine with SeNPs and BCG adjuvants in mice [PDF]

AMB Express
Staphylococcus aureus is a major cause of nosocomial infections and antimicrobial resistance, emphasizing the urgent need for an effective vaccine. The IsdE protein, a heme-iron transporter, has been identified as a promising antigen target.
Fatemeh Khosravani pour, Setareh Haghighat, Mohammad Hossein Yazdi, Seyed Mehdi Hassanzadeh   +3 more
doaj   +2 more sources

Combining Intramuscular and Intranasal Immunization With the MF59‐Adjuvanted Respiratory Syncytial Virus Pre‐Fusion Protein Subunit Vaccine Induces Potent Humoral and Cellular Immune Responses in Mice [PDF]

MedComm
Respiratory syncytial virus (RSV) ranks as the second leading cause of infant death globally and a significant contributor to morbidity and mortality among adults over 60 years old.
Jie Shi, Hong Lei, Yu Zhang, Chunjun Ye, Xiya Huang, Yishan Lu, Yanyan Liu, Jian Liu, Danyi Ao, Yingqiong Zhou, Jiong Li, Guangwen Lu, Xiangrong Song, Xiawei Wei   +13 more
doaj   +2 more sources

Investigating the In Vitro Immunomodulatory Potential of Microparticulate β-L-Adenosine in Particulate Vaccine Candidates [PDF]

Vaccines
Background: Immunomodulatory compounds can modify or regulate the immune responses. Given that vaccine-induced immune responses can vary in magnitude and durability depending on antigen properties and adjuvant selection.
Snehitha Akkineni, Dedeepya Pasupuleti, Mahek Anil Gulani, Yash Harsoda, Martin J. D’Souza, Christiane Chbib, Mohammad N. Uddin   +6 more
doaj   +2 more sources

Efficacy of Immunostimulatory Adjuvants and Nano‐Adjuvants in Current SARS‐CoV‐2 Vaccines: A Comprehensive Review [PDF]

Health Science Reports
Background and Aims SARS‐CoV‐2 continues to pose global challenges, and current vaccines face limitations (variant escape, waning immunity). This review evaluates immunostimulatory adjuvants and nano‐adjuvants to enhance immune responses and optimize ...
Peyman Kheirandish Zarandi, Mohammad Reza Zinatizadeh, Mohsen Ghiasi, Mohammad Rezaei Zadeh Rukerd, Hanieh Mirkamali, Ehsan Shokri   +5 more
doaj   +2 more sources

PPD in HBsAg vaccine formulation suppressed IFN-γ and IL-4 cytokine responses and induced long-lived humoral immune responses: Results from 220-day monitoring of specific IgG responses [PDF]

Iranian Journal of Basic Medical Sciences, 2022
Objective(s): HBsAg vaccine is unable to induce Th1 immune responses. Here, immune responses and long-lived IgG responses of HBsAg-Alum, HBsAg-MF59, as well as HBsAg-MF59 were compared when formulated with PPD.
Rayhaneh Mirzaee, Fahimeh Nemati Mansoor, Mina Mirzaee, Bahareh Golkaran, Akbar Khorasani, Niloufar Rashedi, Fatemeh Asgarhalvaei, Mohammad Ali Savoji, Mehdi Mahdavi   +8 more
doaj   +1 more source

Effects of Adjuvant and Immunization Route on Antibody Responses against Naja Naja oxiana Venom [PDF]

Archives of Razi Institute, 2023
Naja naja oxiana (NNO) is one of the important venomous species in Iran. The current snakebite treatment is antivenom therapy that deals with hyper immunization of horses with crude or fractionated snake venom plus traditional adjuvants, like Freund’s ...
Sh Kashkooli, S Khamehchian, M Dabaghian, M Namvarpour, M Tebianian   +4 more
doaj   +1 more source

Poloxamer-188 Adjuvant Efficiently Maintains Adaptive Immunity of SARS-CoV-2 RBD Subunit Vaccination through Repressing p38MAPK Signaling

Vaccines, 2022
Poloxamer-188 (P188) is a nonionic triblock linear copolymer that can be used as a pharmaceutical excipient because of its amphiphilic nature. This study investigated whether P188 can act as an adjuvant to improve the immunogenicity of severe acute ...
Chao-Hung Chen, Yu-Jen Lin, Li-Ting Cheng, Chien-Hung Lin, Guan-Ming Ke   +4 more
doaj   +1 more source

Evaluation of Immunogenicity of Clostridium perfringens Type B Toxoid and Inactivated FMD (O) Virus with Adjuvant (ISA70-MF59) [PDF]

Archives of Razi Institute, 2023
Foot and mouth disease (FMD) and enterotoxemia are important diseases of hoofed animals. Vaccination against livestock pathogens, especially these two diseases, plays a key role in the prevention and control of these diseases.
A Araghi, M Taghizadeh, S. R Hosseini Doust, A Paradise, S. M Azimi Dezfouli   +4 more
doaj   +1 more source

Evaluating the Immune Response of Recombinant H1N1 Hemagglutinin with MF59 Adjuvant in Animal Model as a Novel Alternative to the Influenza Vaccine

Iranian Journal of Allergy, Asthma and Immunology, 2020
The H1N1 influenza virus is known as a serious pandemic threat across the globe. Vaccination is one of the most effective methods of protection against this virus and the way to reduce the seasonal pandemic risk.
Niloufar Rashedi, Morteza Taghizadeh, Parisa Mohamadynejad, Mehdi Mahdavi, Reza Jalalirad   +4 more
doaj   +1 more source