Results 41 to 50 of about 1,870 (159)

Genetically Engineered Transvestites Reveal Novel Mating Genes in Budding Yeast [PDF]

open access: yes, 2014
Haploid budding yeast has two mating types, defined by the alleles of the MAT locus, MATa and MATα. Two haploid cells of opposite mating types mate by signaling to each other using reciprocal pheromones and receptors, polarizing and growing towards each ...
Huberman, Lori Bromer, Murray, Andrew W.
core   +1 more source

Porphyromonas gingivalis evasion of autophagy and intracellular killing by human myeloid dendritic cells involves DC-SIGN-TLR2 crosstalk.

open access: yesPLoS Pathogens, 2015
Signaling via pattern recognition receptors (PRRs) expressed on professional antigen presenting cells, such as dendritic cells (DCs), is crucial to the fate of engulfed microbes.
Ahmed R El-Awady   +11 more
doaj   +1 more source

Scratching the surface – tobacco-induced bacterial biofilms [PDF]

open access: yes, 2015
Individual environmental factors, such as iron, temperature and oxygen, are known to have a profound effect on bacterial phenotype. Therefore, it is surprising so little known is about the influence of chemically complex cigarette smoke on bacterial ...
Bagaitkar, Juhi   +2 more
core   +2 more sources

Porphyromonas gingivalis Provokes Exosome Secretion and Paracrine Immune Senescence in Bystander Dendritic Cells

open access: yesFrontiers in Cellular and Infection Microbiology, 2021
Periodontitis is a disease of ageing or inflammaging, and is comorbid with other more severe age-related chronic diseases. With advanced age comes an increase in accumulation of senescent cells that release soluble and insoluble pro-inflammatory factors ...
Ranya Elsayed   +5 more
doaj   +1 more source

Disruption of Immune Homeostasis in Human Dendritic Cells via Regulation of Autophagy and Apoptosis by Porphyromonas gingivalis

open access: yesFrontiers in Immunology, 2019
As fundamental processes of immune homeostasis, autophagy, and apoptosis must be maintained to mitigate risk of chronic inflammation and autoimmune diseases.
Mohamed M. Meghil   +9 more
doaj   +1 more source

Oral community interactions of Filifactor alocis in vitro. [PDF]

open access: yesPLoS ONE, 2013
Filifactor alocis is a gram positive anaerobe that is emerging as an important periodontal pathogen. In the oral cavity F. alocis colonizes polymicrobial biofilm communities; however, little is known regarding the nature of the interactions between F ...
Qian Wang   +4 more
doaj   +1 more source

Mean Field Approach for a Statistical Mechanical Model of Proteins

open access: yes, 2003
We study the thermodynamical properties of a topology-based model proposed by Galzitskaya and Finkelstein for the description of protein folding. We devise and test three different mean-field approaches for the model, that simplify the treatment without ...
Fabio Cecconi   +2 more
core   +1 more source

Fun with Facebook: The Impact of Focus Groups on the Development of Awareness Campaigns for Adolescent Health [PDF]

open access: yes, 2011
This project presents a model for developing effective communication by directly engaging designers with their adolescent audience. By conducting focus groups with local youth, we wanted to learn about 1) attitudes and prior knowledge about the areas ...
Sanematsu, Helen
core   +5 more sources

(Semi-)Predictive Discretization During Model Selection [PDF]

open access: yes, 2003
In this paper, we present an approach to discretizing multivariate continuous data while learning the structure of a graphical model. We derive the joint scoring function from the principle of predictive accuracy, which inherently ensures the optimal
D. Heckerman   +5 more
core   +1 more source

Tobacco upregulates P. gingivalis fimbrial proteins which induce TLR2 hyposensitivity.

open access: yesPLoS ONE, 2010
BackgroundTobacco smokers are more susceptible to periodontitis than non-smokers but exhibit reduced signs of clinical inflammation. The underlying mechanisms are unknown.
Juhi Bagaitkar   +5 more
doaj   +1 more source

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