Results 221 to 230 of about 16,053 (242)

Quercetin Promotes the Repair of Mitochondrial Function in H9c2 Cells Through the miR-92a-3p/Mfn1 Axis.

Current Pharmaceutical Biotechnology
OBJECTIVE Cardiocerebrovascular disease is a severe threat to human health. Quercetin has a wide range of pharmacological effects such as antitumor and antioxidant.
Fen Li, Dongsheng Li, Xisheng Yan, F. Zhu, Shifan Tang, Jianguang Liu, Jie Yan, Haifeng Chen   +7 more
semanticscholar   +3 more sources

Mitochondria elongation is mediated through SIRT1-mediated MFN1 stabilization

Cellular Signalling, 2017
Mitochondria are highly dynamic organelles that change size and morphology by fusing together or dividing through fission. In response to cellular cues, signaling cascades may post-translationally modify mitochondria-shaping proteins, which lead to a change in mitochondria morphology.
Hyeseong Cho
exaly   +3 more sources

Mitoquinone mitigates paraquat‐induced A549 lung epithelial cell injury by promoting MFN1/MFN2‐mediated mitochondrial fusion

Journal of Biochemical and Molecular Toxicology, 2022
AbstractParaquat (PQ) poisoning often leads to severe lung injuries, in which the mitochondria damage plays a critical role. Mitoquinone (MitoQ), a newly designed mitochondria‐targeted antioxidant, has been proved for its benefit in mitochondria protection. However, the role of MitoQ in PQ‐induced lung injury remains unclear.
Chao Liu, Zhaorui Sun, Meng-meng Wang, Zhizhou Yang, Wei Zhang, Yi Ren, Xiao-qin Han, Bo Zhang, Mengya Yao, Shinan Nie   +9 more
semanticscholar   +3 more sources

Identification and characterization of signal peptide of Mitofusin1 (Mfn1)

Biochemical and Biophysical Research Communications, 2019
Mitofusin1 (Mfn1) mediates outer mitochondrial membrane (OMM) fusion in Opisthokonts. The uncharacterized TM comprises to two helices (namely, the TM1 and TM2) connected by an intermembrane loop. Consistent with previous studies, our results from in silico analyses show that all mitofusins lack N terminal-MTS and the TM may act an internal MTS. We have
Gopala Krishna Aradhyam
exaly   +3 more sources

MicroRNA-19b targets Mfn1 to inhibit Mfn1-induced apoptosis in osteosarcoma cells

Neoplasma, 2014
Accumulative evidence has confirmed that, miR-17-92, a typical polycistronic mRNA cluster, was up-regulated in various solid tumors, and play an important role in the occurrence and development progress of tumors. In our study, we detected the six members of miR-17-92 cluster in osteosarcoma cell line, finding that the expression of miR-17 and miR-19b ...
X, Li, F S, Wang, Z Y, Wu, J L, Lin, W B, Lan, J H, Lin   +5 more
exaly   +4 more sources

Lanthanum decreased VAPB-PTPP51, BAP31-FIS1, and MFN2-MFN1 expression of mitochondria-associated membranes and induced abnormal autophagy in rat hippocampus.

Food and Chemical Toxicology, 2022
Lanthanum is one of REEs documented to have neurotoxicity that led to learning and memory ability impairments. However, the mechanisms underlying La-induced neurotoxicity remain largely unexplored.
Jinxuan Liu, Liping Wang, Laidi Ge, Wenchang Sun, Zeli Song, Xiaobo Lu, Cuihong Jin, Sheng-wen Wu, Jinghua Yang   +8 more
semanticscholar   +1 more source

Hearts deficient in both Mfn1 and Mfn2 are protected against acute myocardial infarction

Cell Death and Disease, 2016
AbstractMitochondria alter their shape by undergoing cycles of fusion and fission. Changes in mitochondrial morphology impact on the cellular response to stress, and their interactions with other organelles such as the sarcoplasmic reticulum (SR). Inhibiting mitochondrial fission can protect the heart against acute ischemia/reperfusion (I/R) injury ...
Hall, A.R, Burke, N, Dongworth, R.K, Kalkhoran, S.B, Dyson, A, Vicencio, J.M, Dorn, G.W, Yellon, D.M, Hausenloy, D.J   +8 more
exaly   +5 more sources

Associations between OPA1, MFN1, and MFN2 polymorphisms and primary open angle glaucoma in Polish participants of European ancestry

Ophthalmic Genetics, 2021
Background Glaucomatous optic nerve damage is caused by selective death of retinal ganglion cells (RGCs). Another condition with underlying loss of RGCs is autosomal dominant optic atrophy (ADOA).
P. Milanowski, E. Kosior-Jarecka, Urszula Łukasik, D. Wróbel-Dudzińska, Joanna Milanowska, C. Khor, T. Aung, J. Kocki, T. Żarnowski   +8 more
semanticscholar   +1 more source

Inhibition of MFN1 restores tamoxifen-induced apoptosis in resistant cells by disrupting aberrant mitochondrial fusion dynamics.

Cancer Letters
Tamoxifen (TAM) resistance presents a major clinical obstacle in the management of estrogen-sensitive breast cancer, highlighting the need to understand the underlying mechanisms and potential therapeutic approaches.
Yuxuan Song, Shuang Ren, X. Chen, Xuhong Li, Lin Chen, Shijie Zhao, Yue Zhang, Xiangchun Shen, Yan Chen   +8 more
semanticscholar   +1 more source

Tributyltin induces mitochondrial fission through Mfn1 degradation in human induced pluripotent stem cells

Toxicology in Vitro, 2016
Organotin compounds, such as tributyltin (TBT), are well-known endocrine disruptors. TBT is also known to cause various forms of cytotoxicity, including neurotoxicity and immunotoxicity. However, TBT toxicity has not been identified in normal stem cells.
Shigeru, Yamada, Miki, Asanagi, Naoya, Hirata, Hiroshi, Itagaki, Yuko, Sekino, Yasunari, Kanda   +5 more
openaire   +2 more sources