Results 141 to 150 of about 17,786,273 (283)
Cooperativa :: uma nova relação de trabalho - o caso da Unimed Circuito das Águas, São Lourenço/MG / [PDF]
, 2000 Dissertação (Mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico.Verificar se o cooperativismo de trabalho médico, implementado pela UNIMED - Circuito das Águas, São Lourenço/MG, a partir de 1988, representa uma nova alternativa de ...
Silva, Francisco Pereira da
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Molecular Oncology, EarlyView.Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh +11 more
wiley +1 more source
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
CONFLITO PELO USO DO TERRITÓRIO E GENTRIFICAÇÃO: o caso da Alameda em Poços de Caldas (MG) [PDF]
O objetivo deste trabalho é compreender os conflitos pelo uso do território decorrentes da política municipal de gentrificação, bem como as transformações ocorridas a partir do processo de construção da nova Alameda.
Miranda Garcia Pereira , Mirella +2 more
core +1 more source
Effect of Trace Amount of Ca on Corrosion Resistance of Solutionized Mg-4%Zn Alloy
Journal of the Korean Society for Heat Treatment, 2016 Joong-Hwan Jun, In-Je Hwang
openaire +2 more sources
Molecular Oncology, EarlyView.Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler +3 more
wiley +1 more source
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
, 1977 Topical administration of Isoproterenol reduces the intraocular pressure in glaucomatous eyes, but produces systemic side-effects (tachycardia arterial hypotension) that make its clinical use unadvisable.
PESCOSOLIDO, Nicola, MG Bucci
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Molecular Oncology, EarlyView.We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth +17 more
wiley +1 more source