Results 1 to 10 of about 472,378 (232)

High functional allelic diversity and copy number in both MHC classes in the common buzzard [PDF]

BMC Ecology and Evolution, 2023
Background The major histocompatibility complex (MHC), which encodes molecules that recognize various pathogens and parasites and initiates the adaptive immune response in vertebrates, is renowned for its exceptional polymorphism and is a model of ...
Jamie Winternitz, Nayden Chakarov, Tony Rinaud, Meinolf Ottensmann, Oliver Krüger   +4 more
doaj   +2 more sources

Identifying novel amino acid substitutions of hemagglutinin involved in virulence enhancement in H7N9 virus strains

Virology Journal, 2021
Background To identify site-specific features of amino acid substitutions that confer enhanced H7N9 virulence in humans, we independently generated mammalian-adapted variants of A/Anhui/1/2013 (AH-H7N9) and A/Shanghai/2/2013 (SH-H7N9) by serial passaging
Ting Zhang, Haiwei Du, Li Guo, Feng Liu, Haoxiang Su, Fan Yang   +5 more
doaj   +1 more source

Compact genomic architecture of the axolotl MHC region: setting the record straight. [PDF]

Immunogenetics
Migalska M, Fluder K, Dudek K, Babik W.
europepmc   +3 more sources

Transformation of the genital epithelial tract occurs early in California sea lion development [PDF]

Royal Society Open Science, 2016
An unusually high prevalence of metastatic urogenital carcinoma has been observed in free-ranging California sea lions stranded off the coast of California in the past two decades.
Cecilia Barragán-Vargas, Jorge Montano-Frías, Germán Ávila Rosales, Carlos R. Godínez-Reyes, Karina Acevedo-Whitehouse   +4 more
doaj   +1 more source

Lessons from transmissible cancers for immunotherapy and transplant

Immunological Medicine, 2021
The emergence of horizontal transmission of cancer between vertebrates is an issue that interests scientists and medical society. Transmission requires: (i) a mechanism by which cancer cells can transfer to another organism and (ii) a repressed immune ...
Rafael Cardoso Maciel Costa Silva, Carolina Panis, Bruno Ricardo Barreto Pires   +2 more
doaj   +1 more source

In Vitro Model of Suppression of the Alloantigen Response by Tolerogenic Dendritic Cells Transfected with Personalized DNA Constructs Encoding HLA Epitopes

Frontiers in Bioscience-Landmark, 2022
Background: A search for efficient graft rejection modulation techniques for the promotion of durable engraftment remains to be a matter of close study all over the world.
Julia A. Shevchenko, Julia A. Lopatnikova, Julia N. Khantakova, Alexander N. Silkov, Maria S. Kuznetsova, Vasiliy V. Kurilin, Amir Z. Maksyutov, Sergey V. Sennikov   +7 more
doaj   +1 more source

Análisis y revisión de la variación del MHC-B (complejo mayor de Histocompatibilidad) en pollos. Síntesis del trabajo en líneas sintéticas INTA

Ciencia Veterinaria, 2022
El complejo mayor de Histocompatibilidad (MHC del inglés: Major histocompatibility complex) en pollos (Gallus gallus) se encuentra localizado en un micro cromosoma, el 16 del genoma aviar. Así como ocurre en otras especies tiene una fuerte asociación con
Gabriela Marisa Iglesias
doaj   +1 more source

MHC IIB Genetic Diversity and its Association With Humoral Immune Responses in Commercial Turkey [PDF]

Iranian Journal of Veterinary Medicine, 2018
Background: Major histocompatibility complex (MHC) is one of the best characterized genetic regions controlling immune responses against vaccines. Identifying the association between MHC haplotypes and improved immune responses would be useful in genetic
Hassan Alkaragoly, Gholamraza Nikbakhat Brujeni, Atefeh Esmailnejad, Mohammad Hasanzadeh, Tohid Tolouei   +4 more
doaj   +1 more source

Severe COVID-19 and breakthrough infections in vaccinated schizophrenia patients: A matched controlled cohort study

European Psychiatry, 2023
Introduction Schizophrenia patients are at an increased risk for severe SARS-CoV-2 illness. Recent studies indicate that vaccines reduce morbidity gaps between schizophrenia patients and the general population; nonetheless, the ongoing emergence of ...
D. Tzur Bitan
doaj   +1 more source

Evidence for directional selection at a novel major histocompatibility class I marker in wild common frogs (Rana temporaria) exposed to a viral pathogen (Ranavirus). [PDF]

, 2009
(c) 2009 Teacher et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
AA Cunningham, AA Cunningham, AL Hughes, Amber G. F. Teacher, AVS Hill, B Sammut, BC Clarke, BP Shum, D Posada, G Froeschke, GD Maniero, J Gantress, J Maynard Smith, J Robert, JM Seddon, JM Vyas, K Roelants, K Tamura, L Bernatchez, LF Jensen, M Nei, M Nonaka, M Ohtsuka, MA Beaumont, MF Flajnik, MF Flajnik, MF Flajnik, PC Doherty, PW Hedrick, R Frankham, RD Campbell, Richard A. Nichols, Robert DeSalle, S Berlin, S Conseguera, S Kumar, S Rozen, SB Piertney, T Antao, Trenton W. J. Garner, WE Briles, WF Bodmer, Y Ohta   +42 more
core   +6 more sources