Results 1 to 10 of about 554,574 (392)

Targeting MHC-I molecules for cancer: function, mechanism, and therapeutic prospects

Molecular Cancer, 2023
The molecules of Major histocompatibility class I (MHC-I) load peptides and present them on the cell surface, which provided the immune system with the signal to detect and eliminate the infected or cancerous cells. In the context of cancer, owing to the
Xiangyu Wu, Tianhang Li, Rui Jiang, Xin Yang, Hongqian Guo, Rong Yang   +5 more
semanticscholar   +1 more source

Cancer Immune Evasion Through Loss of MHC Class I Antigen Presentation

Frontiers in Immunology, 2021
Major histocompatibility class I (MHC I) molecules bind peptides derived from a cell's expressed genes and then transport and display this antigenic information on the cell surface.
Karthik Dhatchinamoorthy, Jeff D. Colbert, K. Rock   +2 more
semanticscholar   +1 more source

Mechanisms of MHC-I Downregulation and Role in Immunotherapy Response

Frontiers in Immunology, 2022
Immunotherapy has become a key therapeutic strategy in the treatment of many cancers. As a result, research efforts have been aimed at understanding mechanisms of resistance to immunotherapy and how anti-tumor immune response can be therapeutically ...
Brandie C Taylor, J. Balko
semanticscholar   +1 more source

Identifying novel amino acid substitutions of hemagglutinin involved in virulence enhancement in H7N9 virus strains

Virology Journal, 2021
Background To identify site-specific features of amino acid substitutions that confer enhanced H7N9 virulence in humans, we independently generated mammalian-adapted variants of A/Anhui/1/2013 (AH-H7N9) and A/Shanghai/2/2013 (SH-H7N9) by serial passaging
Ting Zhang, Haiwei Du, Li Guo, Feng Liu, Haoxiang Su, Fan Yang   +5 more
doaj   +1 more source

NetMHCpan-4.1 and NetMHCIIpan-4.0: improved predictions of MHC antigen presentation by concurrent motif deconvolution and integration of MS MHC eluted ligand data

Nucleic Acids Res., 2020
Major histocompatibility complex (MHC) molecules are expressed on the cell surface, where they present peptides to T cells, which gives them a key role in the development of T-cell immune responses.
Birkir Reynisson, Bruno Alvarez, S. Paul, Bjoern Peters, M. Nielsen   +4 more
semanticscholar   +1 more source

Transformation of the genital epithelial tract occurs early in California sea lion development [PDF]

Royal Society Open Science, 2016
An unusually high prevalence of metastatic urogenital carcinoma has been observed in free-ranging California sea lions stranded off the coast of California in the past two decades.
Cecilia Barragán-Vargas, Jorge Montano-Frías, Germán Ávila Rosales, Carlos R. Godínez-Reyes, Karina Acevedo-Whitehouse   +4 more
doaj   +1 more source

In Vitro Model of Suppression of the Alloantigen Response by Tolerogenic Dendritic Cells Transfected with Personalized DNA Constructs Encoding HLA Epitopes

Frontiers in Bioscience-Landmark, 2022
Background: A search for efficient graft rejection modulation techniques for the promotion of durable engraftment remains to be a matter of close study all over the world.
Julia A. Shevchenko, Julia A. Lopatnikova, Julia N. Khantakova, Alexander N. Silkov, Maria S. Kuznetsova, Vasiliy V. Kurilin, Amir Z. Maksyutov, Sergey V. Sennikov   +7 more
doaj   +1 more source

Lessons from transmissible cancers for immunotherapy and transplant

Immunological Medicine, 2021
The emergence of horizontal transmission of cancer between vertebrates is an issue that interests scientists and medical society. Transmission requires: (i) a mechanism by which cancer cells can transfer to another organism and (ii) a repressed immune ...
Rafael Cardoso Maciel Costa Silva, Carolina Panis, Bruno Ricardo Barreto Pires   +2 more
doaj   +1 more source

Análisis y revisión de la variación del MHC-B (complejo mayor de Histocompatibilidad) en pollos. Síntesis del trabajo en líneas sintéticas INTA

Ciencia Veterinaria, 2022
El complejo mayor de Histocompatibilidad (MHC del inglés: Major histocompatibility complex) en pollos (Gallus gallus) se encuentra localizado en un micro cromosoma, el 16 del genoma aviar. Así como ocurre en otras especies tiene una fuerte asociación con
Gabriela Marisa Iglesias
doaj   +1 more source

Shapes of MHC Restriction [PDF]

Immunity, 1999
The purpose of TCR ligand binding is to initiate signal transduction that results in the activation of functional programs within the cell. How does binding of ligand on the extracellular V domains of the TCR translate into a functional message inside the cell?
David N. Garboczi, William E. Biddison
openaire   +3 more sources