Results 11 to 20 of about 505,271 (361)

Undergraduate students with and without mental health concerns have different perceptions of disclosing mental health challenges to instructors. [PDF]

PLoS ONE
Many undergraduates report having mental health concerns (MHC), which can reduce academic success. Students with MHC are encouraged to seek help from their instructors but may not because of perceived negative reactions by instructors and peers.
J Michael Sizemore Iii, Bailey Von der Mehden, Elisabeth E Schussler   +2 more
doaj   +2 more sources

Cancer Immune Evasion Through Loss of MHC Class I Antigen Presentation

Frontiers in Immunology, 2021
Major histocompatibility class I (MHC I) molecules bind peptides derived from a cell's expressed genes and then transport and display this antigenic information on the cell surface.
Karthik Dhatchinamoorthy, Jeff D. Colbert, K. Rock   +2 more
semanticscholar   +1 more source

Mechanisms of MHC-I Downregulation and Role in Immunotherapy Response

Frontiers in Immunology, 2022
Immunotherapy has become a key therapeutic strategy in the treatment of many cancers. As a result, research efforts have been aimed at understanding mechanisms of resistance to immunotherapy and how anti-tumor immune response can be therapeutically ...
Brandie C Taylor, J. Balko
semanticscholar   +1 more source

NetMHCpan-4.1 and NetMHCIIpan-4.0: improved predictions of MHC antigen presentation by concurrent motif deconvolution and integration of MS MHC eluted ligand data

Nucleic Acids Res., 2020
Major histocompatibility complex (MHC) molecules are expressed on the cell surface, where they present peptides to T cells, which gives them a key role in the development of T-cell immune responses.
Birkir Reynisson, Bruno Alvarez, S. Paul, Bjoern Peters, M. Nielsen   +4 more
semanticscholar   +1 more source

Autophagy promotes immune evasion of pancreatic cancer by degrading MHC-I

Nature, 2020
Immune evasion is a major obstacle for cancer treatment. Common mechanisms of evasion include impaired antigen presentation caused by mutations or loss of heterozygosity of the major histocompatibility complex class I (MHC-I), which has been implicated ...
Keisuke Yamamoto, Anthony Venida, Julian Yano, Douglas E. Biancur, Miwako Kakiuchi, Suprit Gupta, Albert S W Sohn, Subhadip Mukhopadhyay, E. Lin, Seth J. Parker, Robert S. Banh, J. Paulo, K. Wen, Jayanta Debnath, Grace E. Kim, J. Mancias, D. Fearon, R. Perera, Alec C. Kimmelman   +18 more
semanticscholar   +1 more source

SARS-CoV-2 inhibits induction of the MHC class I pathway by targeting the STAT1-IRF1-NLRC5 axis

Nature Communications, 2021
The MHC class I-mediated antigen presentation pathway plays a critical role in antiviral immunity. Here we show that the MHC class I pathway is targeted by SARS-CoV-2.
Ji-Seung Yoo, M. Sasaki, Steven X. Cho, Yusuke Kasuga, Baohui Zhu, R. Ouda, Y. Orba, P. de Figueiredo, H. Sawa, Koichi S. Kobayashi   +9 more
semanticscholar   +1 more source

NetMHCpan-4.0: Improved Peptide–MHC Class I Interaction Predictions Integrating Eluted Ligand and Peptide Binding Affinity Data

Journal of Immunology, 2017
Cytotoxic T cells are of central importance in the immune system’s response to disease. They recognize defective cells by binding to peptides presented on the cell surface by MHC class I molecules.
V. Jurtz, S. Paul, M. Andreatta, P. Marcatili, Bjoern Peters, M. Nielsen   +5 more
semanticscholar   +2 more sources

Clinical heterogeneity in a family with flail arm syndrome and review of hnRNPA1‐related spectrum

Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1910-1917, December 2022., 2022
Abstract Objective Flail arm syndrome (FAS) is one of the atypical subtypes of amyotrophic lateral sclerosis (ALS). Mutations in hnRNPA1 encoding heterogeneous nuclear ribonucleoprotein (hnRNP) A1 are a rare genetic cause of ALS. Herein, marked clinical heterogeneity of FAS in a pedigree with a known hnRNPA1 variant was described to raise early ...
Xiaochen Han, Feixia Zhan, Yuxin Yao, Li Cao, Jianguo Liu, Sheng Yao   +5 more
wiley   +1 more source

Psychological, clinical and social characteristics of patients implementing different types of aggression in the hospital (gender aspect)

Психология и право, 2015
Results of the comparative analysis of clinical, social and psycho-pathological predictors of violations of the regime requirements, physical and verbal aggression among mentally ill women and men during the compulsory treatment are presented.
Bulygina V.G., Berezkin A. S., Kozlov T. N., Makurina A. P.   +3 more
doaj   +1 more source

MHC Class I Downregulation in Cancer: Underlying Mechanisms and Potential Targets for Cancer Immunotherapy

Cancers, 2020
In recent years, major advances have been made in cancer immunotherapy. This has led to significant improvement in prognosis of cancer patients, especially in the hematological setting.
Annelisa M. Cornel, Iris L Mimpen, S. Nierkens   +2 more
semanticscholar   +1 more source