Results 11 to 20 of about 554,574 (392)
Autophagy promotes immune evasion of pancreatic cancer by degrading MHC-I
Nature, 2020 Immune evasion is a major obstacle for cancer treatment. Common mechanisms of evasion include impaired antigen presentation caused by mutations or loss of heterozygosity of the major histocompatibility complex class I (MHC-I), which has been implicated ...
Keisuke Yamamoto +18 more
semanticscholar +1 more source
SARS-CoV-2 inhibits induction of the MHC class I pathway by targeting the STAT1-IRF1-NLRC5 axis
Nature Communications, 2021 The MHC class I-mediated antigen presentation pathway plays a critical role in antiviral immunity. Here we show that the MHC class I pathway is targeted by SARS-CoV-2.
Ji-Seung Yoo +9 more
semanticscholar +1 more source
Cis interactions of immunoreceptors with MHC and non-MHC ligands [PDF]
Nature Reviews Immunology, 2008 The conventional wisdom is that cell-surface receptors interact with ligands expressed on other cells to mediate cell-to-cell communication (trans interactions). Unexpectedly, it has recently been found that two classes of receptors specific for MHC class I molecules not only interact with MHC class I molecules expressed on opposing cells, but also ...
Roy A. Mariuzza, Werner Held
openaire +2 more sources
European Psychiatry, 2023 Introduction Schizophrenia patients are at an increased risk for severe SARS-CoV-2 illness. Recent studies indicate that vaccines reduce morbidity gaps between schizophrenia patients and the general population; nonetheless, the ongoing emergence of ...
D. Tzur Bitan
doaj +1 more source
Cancers, 2020 In recent years, major advances have been made in cancer immunotherapy. This has led to significant improvement in prognosis of cancer patients, especially in the hematological setting.
Annelisa M. Cornel +2 more
semanticscholar +1 more source
DISTRIBUTION OF MICA ALLELES IN THE RUSSIAN POPULATION
Медицинская иммунология, 2019 Stress factors, infections, tumor transformation of the cells of organism induce the expression of MICA protein, which is a ligand for the NKG2D receptor of NK and T cells.
L. M. Kanevskiy +6 more
doaj +1 more source
MHC IIB Genetic Diversity and its Association With Humoral Immune Responses in Commercial Turkey [PDF]
Iranian Journal of Veterinary Medicine, 2018 Background: Major histocompatibility complex (MHC) is one of the best characterized genetic regions controlling immune responses against vaccines. Identifying the association between MHC haplotypes and improved immune responses would be useful in genetic
Hassan Alkaragoly +4 more
doaj +1 more source
Improved haplotype resolution of highly duplicated MHC genes in a long-read genome assembly using MiSeq amplicons [PDF]
PeerJ, 2023 Long-read sequencing offers a great improvement in the assembly of complex genomic regions, such as the major histocompatibility complex (MHC) region, which can contain both tandemly duplicated MHC genes (paralogs) and high repeat content.
Samantha Mellinger +4 more
doaj +2 more sources
Developmental Cell, 2003 Major histocompatibility complex class Ib molecules may play a surprising role in pheromone detection in mammals.
openaire +2 more sources
454 screening of individual MHC variation in an endemic island passerine [PDF]
, 2014 Genes of the major histocompatibility complex (MHC) code for receptors that are central to the adaptive immune response of vertebrates. These genes are therefore important genetic markers with which to study adaptive genetic variation in the wild.
Gonzalez Quevedo, Catalina +3 more
core +2 more sources