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MHC and MHC‐related proteins as pleiotropic signal molecules
The FASEB Journal, 2002ABSTRACT Class I molecules of the major histocompatibility complex (MHC) have been studied primarily for their role in presenting peptide antigens to conventional T lymphocytes. An increasing body of evidence suggests that MHC and newly characterized MHC‐related molecules have a much more varied function in the ...
David M, Ojcius +3 more
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MHC polymorphism and parasites
Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences, 1994Abstract The major histocompatibility complex (MHC) polymorphism is marked by the existence of allelic lineages that are extremely old, having been passed from one species to another in an evolutionary line of descent. Each species has several of these lineages and many of their more recent derivatives, the actual alleles.
Jan Klein, Colm O'Huigin, J. Deutsch
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Trends in Immunology, 2003
Intestinal intra-epithelial lymphocytes (iIELs) are a major lymphocyte population, reside in close proximity to the intestinal lumen and are conserved throughout vertebrate evolution. iIELs consist of several unique T-cell phenotypes and express both non-rearranged innate immune receptors and rearranged adaptive immune receptors.
Gobardhan, Das, Charles A, Janeway
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Intestinal intra-epithelial lymphocytes (iIELs) are a major lymphocyte population, reside in close proximity to the intestinal lumen and are conserved throughout vertebrate evolution. iIELs consist of several unique T-cell phenotypes and express both non-rearranged innate immune receptors and rearranged adaptive immune receptors.
Gobardhan, Das, Charles A, Janeway
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The MHC haplotypes of the chicken
Immunogenetics, 1982The major histocompatibility complex (MHC) of Gallus gallus is the B complex of which three classes of cell-membrane antigens have been clearly defined by serological, histogenetic, and biochemical methods. Two of these classes are homologous to classes I and II of mammals (B-F and B-L, respectively), while the third (B-G) is a differentiation antigen ...
M, Simonsen, M, Crone, C, Koch, K, Hála
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Current Opinion in Immunology, 1993
In the last year progress has been made towards elucidating the roles of the MHC gene products in autoimmunity. A major advance has been the recent determination of the crystallographic structure of the human MHC class II molecule, which will be invaluable in delineating the minimum structural requirements for peptides that induce autoimmune disease ...
Milner, Caroline, Campbell, R. Duncan
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In the last year progress has been made towards elucidating the roles of the MHC gene products in autoimmunity. A major advance has been the recent determination of the crystallographic structure of the human MHC class II molecule, which will be invaluable in delineating the minimum structural requirements for peptides that induce autoimmune disease ...
Milner, Caroline, Campbell, R. Duncan
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Immunology Letters, 1991
The level of expression of class I and class II MHC antigens in any particular cell is not a fixed characteristic, but is subject to wide fluctuation. The "resting" level of expression varies widely in different cell types, e.g., the cells of the exocrine pancreas and the myocardial cell express neither class I nor class II MHC antigens, whereas B ...
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The level of expression of class I and class II MHC antigens in any particular cell is not a fixed characteristic, but is subject to wide fluctuation. The "resting" level of expression varies widely in different cell types, e.g., the cells of the exocrine pancreas and the myocardial cell express neither class I nor class II MHC antigens, whereas B ...
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1998
Abstract MHC2: A Practical Approach offers a comprehensive and accessible guide to the fast-growing and fascinating field of MHC research. This companion volume to MHC1 covers topics including: generation of HLA-specific human monoclonal antibodies; sequencing of proteins; assembly of MHC molecules; expression, purification, and ...
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Abstract MHC2: A Practical Approach offers a comprehensive and accessible guide to the fast-growing and fascinating field of MHC research. This companion volume to MHC1 covers topics including: generation of HLA-specific human monoclonal antibodies; sequencing of proteins; assembly of MHC molecules; expression, purification, and ...
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2012
Ubiquitinated protein detection is often troublesome since in most cases this modification reduces the half-life of targeted proteins, inducing their degradation. Furthermore, ubiquitination is reversible thanks to the action of highly specific deubiquitinases present in all eukaryotic cells.
Aude, De Gassart +2 more
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Ubiquitinated protein detection is often troublesome since in most cases this modification reduces the half-life of targeted proteins, inducing their degradation. Furthermore, ubiquitination is reversible thanks to the action of highly specific deubiquitinases present in all eukaryotic cells.
Aude, De Gassart +2 more
openaire +2 more sources