Results 21 to 30 of about 505,271 (361)

Improved haplotype resolution of highly duplicated MHC genes in a long-read genome assembly using MiSeq amplicons [PDF]

PeerJ, 2023
Long-read sequencing offers a great improvement in the assembly of complex genomic regions, such as the major histocompatibility complex (MHC) region, which can contain both tandemly duplicated MHC genes (paralogs) and high repeat content.
Samantha Mellinger, Martin Stervander, Max Lundberg, Anna Drews, Helena Westerdahl   +4 more
doaj   +2 more sources

The E5 protein of BPV-4 interacts with the heavy chain of MHC class I and irreversibly retains the MHC complex in the Golgi apparatus [PDF]

, 2006
BPV-4 E5 inhibits transcription of the bovine MHC class I heavy chain (HC) gene, increases degradation of HC and downregulates surface expression of MHC class I by retaining the complex in the Golgi apparatus (GA).
Araibi, E.H., Ashrafi, G.H., Campo, M.S., Dornan, E.S., Ellis, S.A., Marchetti, B.   +5 more
core   +1 more source

ACAMPROSATE AND BACLOFEN WERE NOT EFFECTIVE IN THE TREATMENT OF PATHOLOGICAL GAMBLING: PRELIMINARY BLIND RATER COMPARISON STUDY

Frontiers in Psychiatry, 2011
Objectives: Pathological gambling (PG) is a highly prevalent and disabling impulse control disorder. A range of psychopharmacological options are available for the treatment of PG, including selective serotonin reuptake inhibitors (SSRI), opioid receptor
Pinhas N Dannon, Pinhas N Dannon
doaj   +1 more source

Structure of a Pheromone Receptor-Associated MHC Molecule with an Open and Empty Groove [PDF]

, 2005
Neurons in the murine vomeronasal organ (VNO) express a family of class Ib major histocompatibility complex (MHC) proteins (M10s) that interact with the V2R class of VNO receptors.
Bjorkman, Pamela J., Dulac, Catherine, Huey-Tubman, Kathryn E., Olson, Rich   +3 more
core   +3 more sources

Rapid adaptation during the COVID crisis: Challenges experienced in delivering service to those with Opioid Use Disorders

Implementation Research and Practice, 2022
Background: Adaptation is an accepted part of implementing evidence-based practices. COVID-19 presented a unique opportunity to examine adaptation in evolving contexts.
Holly A. Hills, Rebecca Lengnick-Hall, Kimberly A. Johnson, Wouter Vermeer, C. Hendricks Brown, Mark McGovern   +5 more
doaj   +1 more source

Improved methods for predicting peptide binding affinity to MHC class II molecules

Immunology, 2018
Major histocompatibility complex class II (MHC‐II) molecules are expressed on the surface of professional antigen‐presenting cells where they display peptides to T helper cells, which orchestrate the onset and outcome of many host immune responses ...
Kamilla K Jensen, M. Andreatta, P. Marcatili, S. Buus, J. Greenbaum, Zhen Yan, A. Sette, Bjoern Peters, M. Nielsen   +8 more
semanticscholar   +1 more source

MHC-II neoantigens shape tumor immunity and response to immunotherapy

Nature, 2019
The ability of the immune system to eliminate and shape the immunogenicity of tumours defines the process of cancer immunoediting1. Immunotherapies such as those that target immune checkpoint molecules can be used to augment immune-mediated elimination ...
Elise Alspach, D. Lussier, Alexander P. Miceli, Ilya Kizhvatov, Michel DuPage, Michel DuPage, Adrienne M. Luoma, W. Meng, Cheryl F. Lichti, Ekaterina Esaulova, Anthony N. Vomund, D. Runci, J. Ward, M. Gubin, R. F. Medrano, C. Arthur, J. White, K. Sheehan, Alexander Chen, K. Wucherpfennig, T. Jacks, E. Unanue, M. Artyomov, R. Schreiber   +23 more
semanticscholar   +1 more source

Reconstructing Macroevolutionary Patterns in Avian MHC Architecture With Genomic Data

Frontiers in Genetics, 2022
The Major Histocompatibility Complex (MHC) is a hyper-polymorphic genomic region, which forms a part of the vertebrate adaptive immune system and is crucial for intra- and extra-cellular pathogen recognition (MHC-I and MHC-IIA/B, respectively).
Ke He, Chun-hong Liang, Ying Zhu, Peter Dunn, Ayong Zhao, Piotr Minias   +5 more
doaj   +1 more source

DISTRIBUTION OF MICA ALLELES IN THE RUSSIAN POPULATION

Медицинская иммунология, 2019
Stress factors, infections, tumor transformation of the cells of organism induce the expression of MICA protein, which is a ligand for the NKG2D receptor of NK and T cells.
L. M. Kanevskiy, M. V. Grechikhina, E. G. Kuzmina, T. Yu. Mushkarina, A. A. Spelkov, M. A. Streltsova, E. I. Kovalenko   +6 more
doaj   +1 more source

454 screening of individual MHC variation in an endemic island passerine [PDF]

, 2014
Genes of the major histocompatibility complex (MHC) code for receptors that are central to the adaptive immune response of vertebrates. These genes are therefore important genetic markers with which to study adaptive genetic variation in the wild.
Gonzalez Quevedo, Catalina, Phillips, Karl, Richardson, David, Spurgin, Lewis   +3 more
core   +2 more sources