Results 51 to 60 of about 505,271 (361)

Preen gland microbiota covary with major histocompatibility complex genotype in a songbird

Royal Society Open Science, 2021
Pathogen-mediated selection at the major histocompatibility complex (MHC) is thought to promote MHC-based mate choice in vertebrates. Mounting evidence implicates odour in conveying MHC genotype, but the underlying mechanisms remain uncertain.
L. A. Grieves, G. B. Gloor, M. A. Bernards, E. A. MacDougall-Shackleton   +3 more
doaj   +1 more source

Modular Nucleic Acid Assembled p/MHC Microarrays for Multiplexed Sorting of Antigen-Specific T Cells [PDF]

, 2009
The human immune system consists of a large number of T cells capable of recognizing and responding to antigens derived from various sources. The development of peptide-major histocompatibility (p/MHC) tetrameric complexes has enabled the direct ...
Bailey, Ryan C., Comin-Anduix, Begonya, Hadrup, Sine Reker, Heath, James R., Hwang, Kiwook, Koya, Richard C., Kwong, Gabriel A., Ma, Chao, Radu, Caius G., Ribas, Antoni, Schumacher, Ton N., Shu, Chengyi J., Witte, Owen N.   +12 more
core   +2 more sources

Alu elements within the human major histocompatibility class I region in the Comoros Islands: genetic variation and population relationships

Annals of Human Biology, 2019
Background: Alu elements are attractive markers for population genetics, disease, forensics and paternity analyses, due to their particular characteristics.
Said Nassor Abeid, Majida Motrane, Hamid Farhane, Nourdin Harich   +3 more
doaj   +1 more source

Downregulation of major histocompatibility complex class I in bovine papillomas [PDF]

, 2004
Bovine papillomavirus (BPV) induces papillomas in cattle; in the great majority of cases, these regress due to the host immune response, but they can persist and progress to malignancy.
Araibi, E.H., Ashrafi, G.H., Campo, M.S., Marchetti, B.   +3 more
core   +1 more source

Major histocompatibility complex genomic investigation of endangered Chinese alligator provides insights into the evolution of tetrapod major histocompatibility complex and survival of critically bottlenecked species

Frontiers in Ecology and Evolution, 2022
BackgroundThe major histocompatibility complex (MHC) gene family, a vital immune gene family in vertebrates, helps animals defend against pathogens. The polymorphism of MHC genes is important for a species and is considered to be caused by the numerous ...
Ke He, Ke He, Ying Zhu, Ying Zhu, Shang-Chen Yang, Qing Ye, Qing Ye, Sheng-Guo Fang, Qiu-Hong Wan   +8 more
doaj   +1 more source

How nonuniform contact profiles of T cell receptors modulate thymic selection outcomes [PDF]

Phys. Rev. E 97, 032413 (2018), 2018
T cell receptors (TCRs) bind foreign or self-peptides attached to major histocompatibility complex (MHC) molecules, and the strength of this interaction determines T cell activation. Optimizing the ability of T cells to recognize a diversity of foreign peptides yet be tolerant of self-peptides is crucial for the adaptive immune system to properly ...
arxiv   +1 more source

The Epstein-Barr Virus G-Protein-Coupled Receptor Contributes to Immune Evasion by Targeting MHC Class I Molecules for Degradation [PDF]

, 2009
Epstein-Barr virus (EBV) is a human herpesvirus that persists as a largely subclinical infection in the vast majority of adults worldwide. Recent evidence indicates that an important component of the persistence strategy involves active interference with
AB Rickinson, AD Hislop, AD Hislop, AJ Hirsch, Andrew Currin, B Grinde, B Park, Bryan D. Griffin, CA Joazeiro, CD Gregory, CJ Barnstable, Claire Shannon-Lowe, DA Thorley-Lawson, DA Thorley-Lawson, DH Lee, DT Purtilo, EJ Wiertz, EJ Wiertz, Emmanuel J. H. J. Wiertz, EW Hewitt, F Wang, FC Zhou, GW Wilkinson, H Hengel, H Rabin, HG Guo, HJ Delecluse, HM Long, J Wess, J Yuan, J Zuo, Jianmin Zuo, JL Stern, JP Johnson, K Ahn, K Ahn, K Janvier, Klaus Früh, L Coscoy, L Coscoy, LA Lampson, LS Young, M Greenberg, M Rowe, M Rowe, Maaike E. Ressing, Martin Rowe, ME Ressing, MH Fogg, MH Furman, MJ Clague, MM Rosenkilde, MR Kasper, NB Lubben, NJ Stam, NL Glosson, O Schwartz, P Rivailler, PG Stevenson, PJ Lehner, PS Beisser, R Aasland, R Chaudhuri, R Zeidler, RS Milne, S Bauer, S Drose, S Ishido, S Keating, S Le Gall, S Montaner, SJ Paulsen, SP Lee, SP Lee, TH Meyer, TR Jones, TR Jones, TY Yang, U Reusch, VA Pudney, Wendy A. Thomas, Z Wang   +81 more
core   +4 more sources

Molecular and Genetic Characterization of MHC Deficiency Identifies EZH2 as Therapeutic Target for Enhancing Immune Recognition.

Cancer Discovery, 2019
We performed a genomic, transcriptomic, and immunophenotypic study of 347 patients with diffuse large B-cell lymphoma (DLBCL) to uncover the molecular basis underlying acquired deficiency of MHC expression.
D. Ennishi, K. Takata, W. Béguelin, Gerben Duns, A. Mottok, P. Farinha, Ali Bashashati, Saeed Saberi, M. Boyle, B. Meissner, S. Ben-Neriah, B. Woolcock, A. Telenius, D. Lai, Matt Teater, R. Kridel, K. Savage, L. Sehn, Ryan D. Morin, M. Marra, Sohrab P. Shah, J. Connors, R. Gascoyne, D. Scott, A. Melnick, C. Steidl   +25 more
semanticscholar   +1 more source

Characterization of two MHC II genes (DOB, DRB) in white-tailed deer (Odocoileus virginianus)

BMC Genetics, 2020
Background The major histocompatibility complex (MHC) is responsible for detecting and addressing foreign pathogens inside the body. While the general structure of MHC genes is relatively well conserved among mammalian species, it is notably different ...
Natascha M. D. Ivy-Israel, Carolyn E. Moore, Tonia S. Schwartz, Stephen S. Ditchkoff   +3 more
doaj   +1 more source

Smokers with Self-Reported Mental Health Conditions: A Case for Screening in the Context of Tobacco Cessation Services. [PDF]

PLoS ONE, 2016
People with mental health conditions (MHC) smoke at high rates and many die prematurely from smoking-related illnesses. Smoking cessation programs, however, generally do not screen for MHC.
Gary J Tedeschi, Sharon E Cummins, Christopher M Anderson, Robert M Anthenelli, Yue-Lin Zhuang, Shu-Hong Zhu   +5 more
doaj   +1 more source