Results 91 to 100 of about 534,915 (376)
Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes
Advanced Functional Materials, EarlyView.Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth +2 more
wiley +1 more source
Regulation of major histocompatibility complex class II gene expression in trophoblast cells
Reproductive Biology and Endocrinology, 2004 Trophoblast cells are unique because they are one of the few mammalian cell types that do not express major histocompatibility complex (MHC) class II antigens, either constitutively or after exposure to IFN-γ.
Choi Jason C +2 more
doaj +1 more source
Major Histocompatibility Complex and Cell Cooperation [PDF]
, 2017 We have studied the role of major histocompatibility antigens on cell cooperation in the immune response of the chicken. In the 1970's, shortly after the initial discoveries in the mouse, we demonstrated that the T cell-B cell interaction is major ...
TOIVANEN, AULI +2 more
core
Gut mesenchymal stromal cells in immunity [PDF]
, 2017 Mesenchymal stromal cells (MSCs), first found in bone marrow (BM), are the structural architects of all organs, participating in most biological functions.
Biancone, Livia +9 more
core +4 more sources
PLoS Comput. Biol., 2008 The identification of MHC class II restricted peptide epitopes is an important goal in immunological research. A number of computational tools have been developed for this purpose, but there is a lack of large-scale systematic evaluation of their ...
Peng Wang +5 more
semanticscholar +1 more source
Generation of MHC class II–peptide ligands for CD4 T-cell allorecognition of MHC class II molecules [PDF]
Current Opinion in Organ Transplantation, 2010 The molecular and cellular mechanisms that underlie allorecognition of MHC class II molecules have been the subject of much debate and experimentation in recent decades. In this review, we discuss several aspects of MHC class II structure, peptide acquisition and TcR-MHC-peptide interactions that have particular relevance to recognition of cells ...
Scott A, Leddon, Andrea J, Sant
openaire +2 more sources
Advanced Functional Materials, EarlyView.Bloodstream infections (BSI) are one of the leading causes of mortality and morbidity in both civilian and military populations. This paper summarizes recent progress in novel treatment strategies to manage BSI arising from both bacterial and fungal pathogens using molecules, particles, and materials to elicit host‐directed immunity.
Thomas Thomou +11 more
wiley +1 more source
Lymphocyte activation gene 3: a novel therapeutic target in chronic lymphocytic leukemia
Haematologica, 2017 A novel therapeutic approach in cancer, attempting to stimulate host anti-tumor immunity, involves blocking of immune checkpoints. Lymphocyte activation gene 3 (LAG3) is an immune checkpoint receptor expressed on activated/exhausted T cells. When engaged
Mika Shapiro +9 more
doaj +1 more source
The cytoplasmic domain of CD4 promotes the development of CD4 lineage T cells. [PDF]
, 1996 Thymocytes must bind major histocompatibility complex (MHC) proteins on thymic epithelial cells in order to mature into either CD8+ cytotoxic T cells or CD4+ helper T cells.
Corbella, P +5 more
core
Determination of a predictive cleavage motif for eluted major histocompatibility complex class II ligands [PDF]
, 2018 CD4+ T cells have a major role in regulating immune responses. They are activated by recognition of peptides mostly generated from exogenous antigens through the major histocompatibility complex (MHC) class II pathway.
Dhanda, Sandeep Kumar +7 more
core +6 more sources