Results 111 to 120 of about 243,525 (310)

Prediction of MHC class II binding affinity using SMM-align, a novel stabilization matrix alignment method [PDF]

, 2007
BACKGROUND: Antigen presenting cells (APCs) sample the extra cellular space and present peptides from here to T helper cells, which can be activated if the peptides are of foreign origin.
Morten Nielsen, Claus Lundegaard, Ole Lund, M Nielsen, O Karpenko, V Brusic, H Noguchi, A Sette, B Peters, HH Bui, J Wan, IA Doytchinova, P Donnes, H Singh, T Sturniolo, CP Toseland, JA Swets, WH Press, ST Chang, S Henikoff, GL Zhang, TD Schneider, S Kullback, A Bairoch, N Metropolis, CA Nelson, B Peters, H Rammensee, U Hobohm, M Nielsen   +29 more
core   +2 more sources

Targeting the PGRN‐BMP Lysosomal Axis With NPs@PGRN Reverses Immunometabolic Dysfunction in Chronic Septic Arthritis

Advanced Science, EarlyView.
Chronic septic arthritis involves intracellular bacterial persistence and lipid‐immune crosstalk via the PGRN‐BMP lysosomal axis. A dual‐targeting nanoparticle system (NPs@PGRN) restores lysosomal bactericidal function, reduces bacterial burden, and reprograms macrophage immunity, offering a novel therapeutic strategy. ABSTRACT Chronic septic arthritis,
Congsun Li, Jiaqi Fan, Tao Sun, Wushi Cui, Jiaxuan Zou, Weinan Yang, Liang Chen, Jian Xiao, Shicheng Wang, Tao Zhang, Jianqiao Hong, An Liu, Haobo Wu   +12 more
wiley   +1 more source

Engineering Osteoimmune Responses with Functionalized Orthopedic Implants for Post‐Operative Osteosarcoma Treatment

Advanced Science, EarlyView.
Osteosarcoma is the most common primary bone tumor with limited treatment options and a terrible prognosis. This review provides a comprehensive summary of the recent development of osteoimmunomodulatory implants for post‐operative osteosarcoma treatment, of which the potential utility in evoking durable anti‐osteosarcoma immunity and accelerating bone
Yilong Dong, Lingshuang Wang, Hui Zhang, Menghuan Li, Zhong Luo, Yan Hu, Chunyuan Cai   +6 more
wiley   +1 more source

Improved Systemic Immunochemotherapy Employing an Oxaliplatin‐TLR7/8 Agonist Prodrug Strategy

Advanced Science, EarlyView.
A platinum(IV) prodrug is developed to systemically deliver the TLR7/8 agonist gardiquimod. Tumor‐targeting is mediated by an albumin‐binding maleimide, which limits premature complex activation. Ox‐Gardi‐Mal accumulates specifically in the tumor, where it activates the immune system.
Michael Gutmann, Martijn Dijkstra, Philipp Salomon, Jamie Cowles, Anja Federa, Dina Baier, Carola Jaunecker, Iemima Semerean, Venla Karvonen, Christine Pirker, Maria Sibilia, Dietmar Herndler‐Brandstetter, Petra Heffeter, Bernhard K. Keppler, Christian R. Kowol, Walter Berger   +15 more
wiley   +1 more source

BGN/MDK Axis in the Melanoma Tumor Microenvironment Strengthens Tumor Malignancy by Modulating Cancer Cells and Cancer‐Associated Fibroblasts Crosstalk

Advanced Science, EarlyView.
This study reveals that m6A regulators cooperatively upregulate BGN in melanoma, promoting malignancy. Within the tumor microenvironment, CAFs show highest BGN expression. The BGN/MDK axis mediates cancer‐stroma crosstalk, driving normal fibroblast (NF) activation and enhancing the pro‐tumor effect of CAFs, highlighting a promising therapeutic target ...
Hao‐ze Shi, Ming‐yang Wu, Jin‐quan Liu, Cuicui Tian, Li Ma, Xue‐mei Zhou, Ze‐Hao Sun, Zhi‐yong Xu, Run‐dong Zhang, Shan‐yuan Ye, Li‐ming Huang, Yan Wang, Jing‐shu Xiong, Wen‐bo Bu, Xian‐feng Cheng, Jian‐fang Sun, Hao Chen   +16 more
wiley   +1 more source

Salmonella Typhimurium interferes with the humoral immune response in pigs [PDF]

, 2011
Foodborne salmonellosis is one of the most important bacterial zoonotic diseases worldwide. Salmonella Typhimurium is the serovar most frequently isolated from slaughter pigs in Europe.
Boyen, Filip, Flahou, Bram, Haesebrouck, Freddy, Leyman, Bregje, Maes, Dominiek, Pasmans, Frank, Van Parys, Alexander, Verbrugghe, Elin   +7 more
core  

In vitro propagation and homing of liver-derived dendritic cell progenitors to lymphoid tissues of allogeneic recipients: Implications for the establishment and maintenance of donor cell chimerism following liver transplantation [PDF]

, 1995
Dendritic cell (DC) progenitors were propagated in liquid culture from nonparenchymal cells resident in normal mouse (B10.BR; H-2k, I-E+) liver in response to granulocyte-macrophage colony stimulating factor (GM-CSF).
Fung, JJ, Li, Y, Lu, L, Qian, S, Rao, AS, Starzl, TE, Subbotin, VM, Thomson, AW   +7 more
core   +1 more source

Cuproptosis and Disulfidptosis Converge to Empower PD‐L1 Checkpoint Therapy via Cadict‐Induced PD‐L1 Translation

Advanced Science, EarlyView.
This study introduces Cadict, an EGFR‐targeted nanodrug that co‐delivers cuproptosis and disulfidptosis inducers to overcome immune resistance. Cadict synergistically enhances tumor cytotoxicity and sensitizes cancers to ICIs by upregulating PD‐L1 via an Eif5b‐dependent translation mechanism, fostering a potent antitumor immune response and ...
Shaoqing Huang, Shiyao Song, Xinhua Zhang, Jialing Gao, Ruihan Pu, Jiatong Dai, Xiaoxue Wu, Lulu Chen, Qinghai Li, Xiaoting Liu, Qi Zhou, Mei Song, Weiling He   +12 more
wiley   +1 more source

Major histocompatibility complex (MHC) fragment numbers alone – in Atlantic cod and in general - do not represent functional variability [version 1; referees: 2 approved, 1 approved with reservations]

F1000Research, 2018
This correspondence concerns a publication by Malmstrøm et al. in Nature Genetics in October 2016. Malmstrøm et al. made an important contribution to fish phylogeny research by using low-coverage genome sequencing for comparison of 66 teleost (modern ...
Johannes M. Dijkstra, Unni Grimholt
doaj   +1 more source

Early passenger leukocyte migration and acute immune reactions in the rat recipient spleen during liver engraftment: With particular emphasis on donor major histocompatibility complex class II⁺ cells [PDF]

, 2002
After a short course of tacrolimus, Lewis rat liver allografts induce donor-specific nonreactivity in Brown Norway recipients that is immunosuppression-independent after 28 days.
Anthony J. Demetris, Bishop, Calne, Cohn, Corry, Demetris, Demetris, Demetris, Demetris, Gill, Gould, Ichikawa, Iwaki, Jurcevic, Kamada, Ko, Larsen, Lechler, Lechler, Lu, Matzinger, Mosmann, Murase, Murase, Murase, Naoya Ichikawa, Nemlander, Nickerson, Noriko Murase, Ochsenbein, Olga Azhipa, Qian, Qian, Rogers, Russell, Sakamoto, Schlitt, Shoskes, Sims, Smith, Starzl, Starzl, Starzl, Starzl, Steinman, Steinman, Takashi Ishikawa, Terakura, Thomas E. Starzl, Thomson, Toyokazu Okuda, Vremec, Wekerle, Womer, Wood, Yagihashi, Zinkernagel   +56 more
core   +1 more source