Results 81 to 90 of about 243,525 (310)

Optimal MHC-II-restricted tumor antigen presentation to CD4+ T helper cells: the key issue for development of anti-tumor vaccines [PDF]

, 2012
Present immunoprevention and immunotherapeutic approaches against cancer suffer from the limitation of being not “sterilizing” procedures, as very poor protection against the tumor is obtained.
A Bonehill, A Garcia-Lora, A Mantovani, A Rudensky, A Sica, AA Lugade, B Ruffell, B Yamini, C Jochems, D Atanackovic, D Jaraquemada, D Schimd, DM Pardoll, E Balza, E Balza, E De Plaen, EA Mittendorf, EA Reits, F Garrido, F Ossendorp, G Dranoff, Giovanna Tosi, H Nishikawa, J Lee, J-M Brulet, JA Harton, K Hui, K Hung, KE de Visser, L Borsi, L Mortara, L Mortara, L Mortara, L Qi, L Zitvogel, M Vesely, NA Mitchison, O Makela, R Claus, R Meazza, RA Lake, RM Chicz, RM Zinkernagel, RN Germain, Roberto S Accolla, RS Accolla, S Dissanayake, S Sakaguchi, S Sartoris, SA Rosenberg, SA Rosenberg, T Armstrong, T Kageshita, T Takeshima, V Frangione, V Steimle, YP Liao   +56 more
core   +1 more source

Infusible Extracellular Matrix Biomaterial Enhances Cell‐Specific Pro‐Repair Responses Following Acute Myocardial Infarction

Advanced Healthcare Materials, EarlyView.
We measure the cell‐specific responses of administering infusible ECM (iECM) in acute myocardial infarction (MI) across multiple timepoints. Using single‐nucleus RNA sequencing and spatial transcriptomics, we measure macrophage activation, fibroblast remodeling, increased vascular development, lymphangiogenesis, cardioprotection, and neurogenesis ...
Joshua M. Mesfin, Alexander Chen, Quincy P. Lyons, Michael B. Nguyen, Maria L. Karkanitsa, Justin Yu, Van K. Ninh, Emily Gardner, Elyse G. Wong, Sriya N. Paleti, Julian Cheng, Benjamin D. Bridgelal, Kate E. Reimold, Selena Cao, Connor Uhre, Colin G. Luo, Zhenxing Fu, Kevin R. King, Karen L. Christman   +18 more
wiley   +1 more source

Regulation of major histocompatibility complex class II gene expression in trophoblast cells

Reproductive Biology and Endocrinology, 2004
Trophoblast cells are unique because they are one of the few mammalian cell types that do not express major histocompatibility complex (MHC) class II antigens, either constitutively or after exposure to IFN-γ.
Choi Jason C, Murphy Shawn P, Holtz Renae   +2 more
doaj   +1 more source

Identification of MHC Class II Binders/ Non-binders using Negative Selection Algorithm [PDF]

, 2011
The identification of major histocompatibility complex (MHC) class-II restricted peptides is an important goal in human immunological research leading to peptide based vaccine design. These MHC class–II peptides are predominantly recognized by CD4+
B. N. Mishra, Bharat Bhasker, Feroz Khan, S.S. Soam   +3 more
core   +1 more source

Role of membrane environment and membrane-spanning protein regions in assembly and function of the Class II Major Histocompatibility complex [PDF]

, 2019
Class II Major Histocompatibility complex (MHC-II) is a polymorphic heterodimer that binds antigen-derived peptides and presents them on the surface of antigen presenting cells.
Dixon, Ann M., Roy, Syamal
core   +1 more source

Small Extracellular Vesicles from Neural Cells: Physiological and Pathological Roles, and Potential in Neurodegenerative Therapy

Advanced Healthcare Materials, EarlyView.
Neural cell–derived small extracellular vesicles (sEVs) are emerging as pivotal mediators in neurodegenerative diseases, exerting both pathogenic and therapeutic functions. This review synthesizes current evidence on how sEVs from distinct neural cell types regulate neurodegeneration, neuroprotection, biomarker discovery, and targeted drug delivery ...
Muhammad Waqas Salim, Wei Zhang, Lyndsey Collins‐Praino, Yuling Wang, Andrew Care   +4 more
wiley   +1 more source

The cytoplasmic domain of CD4 promotes the development of CD4 lineage T cells. [PDF]

, 1996
Thymocytes must bind major histocompatibility complex (MHC) proteins on thymic epithelial cells in order to mature into either CD8+ cytotoxic T cells or CD4+ helper T cells.
Corbella, P, Itano, A, Kioussis, D, ROBEY, Ellen, Salmon, P, Tolaini, M   +5 more
core  

Positional identification and functional analysis of genes regulating autoimmune arthritis [PDF]

, 2016
The major histocompatibility complex (MHC) is the most gene-dense and polymorphic region in the human genome with strong associations to many autoimmune disorders, including rheumatoid arthritis (RA).
Yau, Anthony Chun Yeung
core   +1 more source

Opinion: Gavage Administration of MXene as a Route‐Specific Alternative to Intravenous Injection into the Bloodstream of Laboratory Animals for Reducing Systemic Nanotoxicity Risks in Immunosuppression and Post‐Transplantation Models with Bile Acid Modification

Advanced Healthcare Materials, EarlyView.
Recent studies reported immunosuppressive properties of specific MXene nanomaterials. Their intravenous injection into the bloodstream of laboratory animals has been a common delivery method to suppress systemic inflammation and prevent transplant rejection.
Alireza Rafieerad, M. Akif Rahman, Ahmad Amiri   +2 more
wiley   +1 more source

Safe and Localized Lentiviral Gene Delivery via Injectable Mesoporous Scaffolds for Potent Antitumor Immunity

Advanced Materials, EarlyView.
This work introduces an injectable mesoporous silica rod scaffold that confines lentiviral vectors to the injection site, enabling localized dendritic cell recruitment and transduction. The platform sustains antigen expression, promotes robust T‐cell activation, and enhances antitumor immunity.
Thanh Loc Nguyen, Yeon‐ju Kim, Jihye Im, Dong Kwang Min, Hyunsu Shin, Thuy An Trinh, Ngoc Man Phan, Min‐jeong Son, Ji‐yeon Shim, Ye‐lim Lee, Yujeong Ha, Kwang‐il Lim, Jaeyun Kim   +12 more
wiley   +1 more source