Results 111 to 120 of about 534,915 (376)

Antigen loading of MHC class I molecules in the endocytic tract [PDF]

, 2001
Major histocompatibility complex (MHC) class I molecules bind antigenic peptides that are translocated from the cytosol into the endoplasmic reticulum by the transporter associated with antigen processing.
Albert, Amigorena, Aragnol, Arnold-Schild, Bachmann, Banchereau, Barnstable, Bevan, Campbell, Castellino, Cresswell, Dasgupta, De Bruijn, Escola, Germain, Geuze, Griffin, Grommé, Hammond, Harding, Huang, Johnstone, Jondal, Keene, Kleijmeer, Kleijmeer, Kovacsovics-Bankowski, Lamb, Liu, Liu, Matzinger, Mellins, Morton, Neuman, Norbury, Pan, Peters, Pfeifer, Raposo, Raposo, Reid, Reis e Sousa, Ridge, Rock, Rock, Rodriguez, Romani, Schirmbeck, Schirmbeck, Schirmbeck, Schoenberger, Spies, Sugita, Théry, Townsend, Trowsdale, Tse, Ulmer, Urban, Van Binnendijk, Vega, Vigna, Watts, West, Wolf, Yewdell, Zhou, Ziegler, Zitvogel   +68 more
core   +2 more sources

A Single‐Metal‐Doped Nanoplatform for Ferroptosis‐Driven cGAS‐STING Pathway Activation in Hepatocellular Carcinoma Immunotherapy

Advanced Functional Materials, EarlyView.
The cGAS‐STING pathway boosts HCC antitumor immunity but lacks specific activation. Nanoplatform ZMRPF induces HCC ferroptosis via lipid ROS, releasing mtDNA. It synergizes with ZMRPF‐released Mn2⁺ to activate cGAS‐STING, amplifies antigen‐presenting cell activity, reverses HCC immunosuppression, and enables robust systemic antitumor immunity ...
Yuchen Zhang, Shuang Feng, Jie Luo, Kaige Xu, Junfeng Guo, Xingyue Zhang, Mengxue Yuan, Qiang Luo, Yu Huang, Chaoqiang Fan, Kibret Mequanint, Donghui Zhu, Malcolm Xing, Shiming Yang   +13 more
wiley   +1 more source

Boosting immune response with the invariant chain segments via association with non-peptide binding region of major histocompatibility complex class II molecules

BMC Immunology, 2012
Background Based on binding of invariant chain (Ii) to major histocompatibility complex (MHC) class II molecules to form complexes, Ii-segment hybrids, Ii-key structure linking an epitope, or Ii class II-associated invariant chain peptide (CLIP) replaced
Chen Fangfang, Meng Fantao, Pan Ling, Xu Fazhi, Liu Xuelan, Yu Weiyi   +5 more
doaj   +1 more source

Model for the Interaction of T-cell Receptors with Peptide/MHC Complexes [PDF]

, 1989
The immune response against a viral infection is mediated by two different types of cells known as B and T lymphocytes. The receptor on the B cell is the well-characterized antibody molecule, which exists in a membrane-bound form and in a secreted form ...
Bjorkman, P. J., Davis, M. M.
core   +1 more source

Synthetic Nanobiology Actuated Lipometabolic Cell Factory for Autologous Tumor Immunotherapy

Advanced Functional Materials, EarlyView.
FA plays a crucial role in the interaction between tumor cells and the tumor microenvironment, especially for the immune response. A biocatalytic immunoenhancement strategy is developed to boost antitumor immunity by FA metabolic orientation to ceramide. Through the design of this delicate catalytic immunoenhancement strategy, the synthetic nanobiology
Shoujie Zhao, Yejing Zhu, Hengchao Yu, Jun Zhu, Bo Wang, Yu Qiao, Zhimin Tian, Junlong Zhao, Lei Liu   +8 more
wiley   +1 more source

Endogenous antigen presentation of MHC class II epitopes through non-autophagic pathways

Frontiers in Immunology, 2015
Antigenic peptides presented by major histocompatibility complex (MHC) class II molecules are generally derived from exogenous proteins acquired by antigen presenting cells. However, in some circumstances, MHC class II molecules can present intracellular
Carol Sze Ki eLeung
doaj   +1 more source

CIITA-induced occupation of MHC class II promoters is independent of the cooperative stabilization of the promoter-bound multi-protein complexes [PDF]

, 2017
Precise regulation of MHC class II expression plays a crucial role in the control of the immune response. The transactivator CIITA behaves as a master controller of constitutive and inducible MHC class II gene activation, but its exact mechanism of ...
Bontron, Séverine, Mach, Bernard, Muhlethaler-Mottet, Annick, Reith, Walter, Villard, Jean   +4 more
core  

The tammar wallaby major histocompatibility complex shows evidence of past genomic instability [PDF]

, 2011
RIGHTS : This article is licensed under the BioMed Central licence at http://www.biomedcentral.com/about/license which is similar to the 'Creative Commons Attribution Licence'.
Beck, S, Belov, K, Coggill, P, Deakin, JE, Harrow, J, Kaufman, J, Siddle, HV, Whilming, L   +7 more
core   +6 more sources

MHC Class II Deficiency

Medicine, 2001
IntroductionPrimary human immunodeficiencies constitute a heterogenous group of inborn errors of the immune system due to a variety of genetic abnormalities. The study of patients with primary immunodeficiency diseases has expanded our understanding of immunity.
J, Villard, K, Masternak, B, Lisowska-Grospierre, A, Fischer, W, Reith   +4 more
openaire   +2 more sources

ROS‐Triggered Microgels for Programmable Drug Release in Volumetric Muscle Loss Repair

Advanced Healthcare Materials, EarlyView.
Reduced graphene oxide‐incorporated hyaluronic acid microgels are developed as ROS‐responsive, injectable platforms for curcumin delivery in volumetric muscle loss. The microgels exhibit strong antioxidative activity, high drug‐loading capacity, and ROS‐triggered release.
Seungjun Lee, Goeun Choe, Junghyun Kim, Junggeon Park, Jia Yi Erica Kok, Jae Young Lee   +5 more
wiley   +1 more source