Advanced Science, EarlyView.A multifaceted chemical strategy, integrating bacterial tropism, metal‐ion interference therapy, and immunotherapy, resulted in significant tumor regression in murine models. A pioneering paradigm for the design of biohybrid materials was established, highlighting how sophisticated chemical engineering of living systems can unlock new avenues for ...
Tingting Zhang +7 more
wiley +1 more source
Protocol to measure the kinetics of MHC class II-influenza A binding using biolayer interferometry. [PDF]
STAR ProtocCardenas M +6 more
europepmc +1 more source
Bacterial Outer Membrane Vesicles in Potentiating Cancer Vaccines: Progress and Prospects
Advanced Science, EarlyView.Bacterial outer membrane vesicles (OMVs) have emerged as versatile platforms for cancer vaccine development owing to their intrinsic immunostimulatory properties and high engineering flexibility. This review summarizes OMV biology, immune mechanisms, and engineering strategies that enhance vaccine efficacy, discusses key translational challenges, and ...
Jiabeini Zhang +9 more
wiley +1 more source
Case Report: A novel CIITA mutation causing MHC class II deficiency: first reported case in Morocco. [PDF]
Front ImmunolKattra AB +9 more
europepmc +1 more source
Extracellular Vesicles in Autoimmune Diseases: From Diagnostic Biomarkers to Engineered Therapeutics
Advanced Science, EarlyView.This review provides a systematic comparison of extracellular vesicles (EVs) from both mammalian and plant sources in the context of autoimmune diseases. It highlights their emerging roles as precision biomarkers and engineered therapeutic platforms.
Yufei Wu +6 more
wiley +1 more source
Association of MHC class II β domain polymorphism in channel catfish (Ictalurus punctatus) with natural infection by Ligictaluridus floridanus. [PDF]
Parasitol ResRoldán GMG +5 more
europepmc +1 more source
The MHC Class II Antigen-Processing and Presentation Pathway Is Dysregulated in Type 1 Diabetes. [PDF]
J Immunol, 2023 Gilles A +6 more
europepmc +1 more source
Leveraging Artificial Intelligence and Large Language Models for Cancer Immunotherapy
Advanced Science, EarlyView.Cancer immunotherapy faces challenges in predicting treatment responses and understanding resistance mechanisms. Artificial intelligence (AI) and machine learning (ML) offer powerful solutions for cancer immunotherapy in patient stratification, biomarker discovery, treatment strategy optimization, and foundation model development.
Xinchao Wu +4 more
wiley +1 more source
A superantigen-based MHC class II-targeted cancer immunotherapy for the treatment of acute myeloid leukemia. [PDF]
Blood Cancer JGolick L +7 more
europepmc +1 more source
Advanced Science, EarlyView.Understanding protein sequence–function relationships remains challenging due to poorly defined motifs and limited residue‐level annotations. An annotation‐agnostic framework is introduced that segments protein sequences into “protein words” using attention patterns from protein language models.
Hedi Chen +9 more
wiley +1 more source