Results 151 to 160 of about 135,004 (265)

Exploring MHC class II I-Ab blockade as a potential treatment for Sjögren's disease in the mouse model. [PDF]

Immunohorizons
Voigt A, Gupta S, Shen Y, Glenton P, Li D, Ostrov D, Bhattacharyya I, Nguyen CQ.   +7 more
europepmc   +1 more source

TrxR2 Lactylation Facilitates Mitochondrial Protection and Endothelial Ferroptosis Resistance in Diabetic Cardiomyopathy

Advanced Science, EarlyView.
TrxR2 deletion in diabetic mice suppresses TUFM‐AMPK‐FUNDC1‐dependent mitophagy in endothelial cells, resulting in SCP2 upregulation and mitochondrial translocation of ACSL4. Mitochondrial ACSL4 promotes mitochondrial eicosanoid biosynthesis and ferroptosis, thereby aggravating cardiac microvascular injury and diabetic cardiomyopathy.
Su Li, Muyin Liu, Chao Chen, Xinyan Li, Xiaopei Yan, Wentao Zhu, Wenyan Qiu, Qiyu Li, Xiangyu Sun, Chao Huang, Ming Yin, Zhangwei Chen, Yao Lu, Junbo Ge, Xiangqing Kong, Juying Qian, Yuqiong Chen   +16 more
wiley   +1 more source

MHC class II presentation of FVIII-AnnexinA5 fusion proteins internalized by antigen presenting cells. [PDF]

Front Immunol
Miranda M, Leoni M, van der Zwaan C, van Bruggen R, Reutelingsperger CPM, Fijnvandraat K, Hoogendijk AJ, van den Biggelaar M, Voorberg J.   +8 more
europepmc   +1 more source

Regulation of MHC Class II Gene Expression

Immunobiology, 1995
Reith, Walter, Steimle, Viktor, Durand, Bénédicte, Kobr, M., Mach, Bernard   +4 more
openaire   +3 more sources

Nanoparticle‐Mediated Immunometabolic‐Epigenetic Remodeling Enhances Schwann Cell‐Macrophage Interaction for Sciatic Nerve Regeneration

Advanced Science, EarlyView.
A biomimetic Prussian White nanoparticle (PW) is engineered to achieve long‐term local retention and orchestrate immunometabolic‐epigenetic remodeling for sciatic nerve regeneration. PW directly targets hexokinase 2 to suppress glycolysis, thereby elevating α‐ketoglutarate and driving Kdm4a/b‐mediated demethylation of H3K9me3.
Wenying Xu, Rongrong Wu, Zhicheng Liu, Hongyu Yan, Huan Zhang, Yuanyi Zheng, Xiaojun Cai   +6 more
wiley   +1 more source

Enhancing DC cancer vaccine by allogeneic MHC class II expression and Treg depletion. [PDF]

JCI Insight
Seishima N, Becker W, Olkhanud PB, Maeng HM, Lopez-Lago MA, Williams WV, Berzofsky JA.   +6 more
europepmc   +1 more source

Aptamer‐Engineered Liposomal Platform Enables in Situ cDC1 Vaccination to Potentiate Immunotherapy in Prostate Cancer

Advanced Science, EarlyView.
Prostate cancer is immunologically ‘cold’, with scarce, dysfunctional type 1 conventional dendritic cells (cDC1s) that limit T cell priming. We introduce an aptamer‐targeted liposomedelivering FMS‐like tyrosine kinase 3 ligand (Flt3L) and chlorin e6 (Ce6). Ultrasound induces antigen release and cDC1s recruitment, creating an in situ cDC1 vaccine.
Jiayi Wang, Xuan Wang, Xinfeng Dai, Linxin Tian, Wencheng Shen, Xueliang Liu, Wei Xue, Jiahua Pan, Yu Yang   +8 more
wiley   +1 more source

Causal ALS genes impact the MHC class II antigen presentation pathway. [PDF]

Proc Natl Acad Sci U S A, 2023
Chi B, Öztürk MM, Paraggio CL, Leonard CE, Sanita ME, Dastpak M, O'Connell JD, Coady JA, Zhang J, Gygi SP, Lopez-Gonzalez R, Yin S, Reed R.   +12 more
europepmc   +1 more source

Studying Macromolecular Composition in Cell–Cell Interfaces Using 3D Membrane Reconstitution Systems

Advanced Science, EarlyView.
A comprehensive understanding of the interactions between proteins, lipids and glycocalyx components at the immune synapse is still lacking. Here, an artificial and a semi‐artificial model contact system were established to reconstitute the cell‐cell contact in 3D. The model systems enable the examination of macromolecule enrichment or depletion at the
Franziska Ragaller, Amelie Maribel Schneider, Ellen Sjule, Renhua Sun, Xiao Han, Luca Andronico, Edward Jenkins, Michael Dustin, Adnane Achour, Erdinc Sezgin   +9 more
wiley   +1 more source

Evidence of Mixed Selection Acting on the MHC Class II <i>DQA</i> Gene in Captive Thai Elephant Populations. [PDF]

Genes (Basel)
Budi T, Enguito MR, Singchat W, Panthum T, Nguyen THD, Chaiyes A, Muangmai N, Griffin DK, Duengkae P, Srikulnath K.   +9 more
europepmc   +1 more source