Results 181 to 190 of about 135,004 (265)

Single‐Cell RNA Sequencing Informs Precision Targeting of Monogenic Lupus Associated With IKZF1 Haploinsufficiency

Arthritis &Rheumatology, EarlyView.
Objective This study aimed to investigate the mechanisms of immune dysregulation in a pediatric patient with monogenic lupus driven by IKZF1 haploinsufficiency. Methods Peripheral immune cells from a patient with IKZF1 haploinsufficiency, patients with lupus with no currently known genetic mutations, and healthy controls were analyzed using single‐cell
Qi Zheng, Yejun Tan, Zhaoling Wang, Yanjie Qian, Qian Ma, Danping Shen, Meiping Lu   +6 more
wiley   +1 more source

MHC class II genotypes are independent predictors of anti-PD1 immunotherapy response in melanoma. [PDF]

Commun Med (Lond)
Claeys A, Van den Eynden J.
europepmc   +1 more source

Investigating the Role of Type I Interferon Signaling on Muscle Disease Using Mouse Models

Arthritis &Rheumatology, EarlyView.
Objective Dysregulated type I interferon (IFN) signaling contributes to autoimmune myositis pathogenesis. We investigated the therapeutic effects of JAK inhibitors in two mouse models. We also examined how type I IFNs affect muscle vasculature. Methods Myositis was induced in major histocompatibility complex class I double transgenic ([TRE‐H‐2Kb (H ...
Rita Spathis, Sabrina Narvesen, Deeva Robles Kuriplach, Karen Huang, Teja Sundar, Elizabeth Bagley, Joanna Parkes, Xinyu Jia, Nandhana Sudhan, Alfredo Guzman, Kanneboyina Nagaraju, Melissa Morales   +11 more
wiley   +1 more source

Plethora of New Marsupial Genomes Informs Our Knowledge of Marsupial MHC Class II. [PDF]

Genome Biol Evol
Silver LW, Hogg CJ, Belov K.
europepmc   +1 more source

Single‐cell level characterization of B cell depletion and repopulation following rituximab in systemic lupus erythematosus

Arthritis &Rheumatology, Accepted Article.
Objective Rituximab, a CD20+ B cell depletion therapy, is frequently used to treat systemic lupus erythematosus (SLE). However, variability in patient response highlights the need for a deeper understanding of the underlying immune cell dynamics of B cell depletion and repopulation.
Haerin Jang, Norzawani Buang, Catherine Sutherland, Wanseon Lee, Lauren Overend, Tarran S. Rupall, Katie L. Burnham, Matthew C. Pickering, Marina Botto, Emma E. Davenport   +9 more
wiley   +1 more source

Defective removal of invariant chain peptides from MHC class II suppresses tumor antigen presentation and promotes tumor growth. [PDF]

Cell Rep
Bandola-Simon J, Ito Y, Wucherpfennig KW, Roche PA.   +3 more
europepmc   +1 more source

The E3 Ubiquitin Ligase UBE3B Regulates Synaptic Development and Cortical Network Activity

Autism Research, EarlyView.
ABSTRACT Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impaired communication, abnormal social interactions, and restricted, repetitive behaviors. Pathogenic mutations in UBE3B result in neurodevelopmental disease, including intellectual disability, lack of speech, and ASD.
Shayal Vashisth, Aleya Shedd, Ariel Aiken, Solmi Cheon, Josh Bandopadhay, Kiran Kaur, Kimberly M. Huber, Maria H. Chahrour   +7 more
wiley   +1 more source

Structural basis for mouse LAG3 interactions with the MHC class II molecule I-A^b. [PDF]

Nat Commun
Ming Q, Antfolk D, Price DA, Manturova A, Medina E, Singh S, Mason C, Tran TH, Smalley KSM, Leung DW, Luca VC.   +10 more
europepmc   +1 more source

Understanding Degradation Mechanisms in Water‐In‐Salt Electrolyte. Part 2: Impact of the Electrochemical Parameters on the Cycling Behavior of LiFePO4 versus TiS2

Batteries &Supercaps, EarlyView.
Cycling water‐in‐salt batteries involves complex degradation processes that require multiprobe analysis. Using online electrochemical mass spectrometry (OEMS), postmortem X‐ray photoemission spectroscopy (XPS) (including hard‐XPS), and scanning electron microscopy (SEM), the degradation mechanisms are examined in composite electrodes (TiS2 and LiFePO4)
Célia Doublet, Théo Faverge, Vincent Martin, Hiram Castillo Michel, Jean‐Pascal Rueff, Marian Chatenet, Lauréline Lecarme, Claire Villevieille   +7 more
wiley   +1 more source

Protective IgM-mediated immunity against <i>Vibrio anguillarum</i> in Atlantic cod with evolutionary losses of <i>mhc class II</i> and <i>cd4</i>. [PDF]

Front Immunol
Jonsson A, López-Porras A, Nørstebø SF, Guslund NC, Sørum H, Qiao SW, Johansen FE.   +6 more
europepmc   +1 more source